Low P-Selectin Glycoprotein Ligand-1 Expression in Neutrophils Associates with Disease Activity and Deregulated NET Formation in Systemic Lupus Erythematosus

Low P-Selectin Glycoprotein Ligand-1 Expression in Neutrophils Associates with Disease Activity and Deregulated NET Formation in Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by the generation of anti-DNA autoantibodies due to exposure of immune cells to excessive amounts of extracellular DNA. Lack of P-selectin in mice induces the development of a lupus-like syndrome and patients with cutaneous lu...

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Bibliographic Details
Main Authors: Antonio Muñoz-Callejas, Elena González-Sánchez, Javier Silván, Esther San Antonio, Rafael González-Tajuelo, Alejandra Ramos-Manzano, Inés Sánchez-Abad, Isidoro González-Alvaro, Javier García-Pérez, Eva G. Tomero, Rosario García de Vicuña, Esther F. Vicente-Rabaneda, Santos Castañeda, Ana Urzainqui
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
PSGL-1
P-selectin
neutrophils
SLE pathogenesis
NETs
Online Access:https://www.mdpi.com/1422-0067/24/7/6144

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