The Risk of Antipsychotic Drugs on Breast Cancer: A Systematic Review and Meta-analysis
Objectives: To investigate the association between the consumption of antipsychotic drugs and breast cancer. Methods: In this systematic review and meta-analysis study, relevant studies were extracted from different databases including PubMed, ScienceDirect, Cochrane, Medline, and additional sources...
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| Format: | Article |
| Language: | English |
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Oman Medical Specialty Board
2022-11-01
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| Series: | Oman Medical Journal |
| Subjects: | |
| Online Access: | https://omjournal.org/articleDetails.aspx?coType=1&aId=3279 |
| _version_ | 1811317052166635520 |
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| author | Anak Agung Bagus Putra Indrakusuma I Gede Krisna Arim Sadeva I Gusti Ngurah Ananda Wira Kusuma Cokorda Bagus Jaya Lesmana Desak Made Wihandani |
| author_facet | Anak Agung Bagus Putra Indrakusuma I Gede Krisna Arim Sadeva I Gusti Ngurah Ananda Wira Kusuma Cokorda Bagus Jaya Lesmana Desak Made Wihandani |
| author_sort | Anak Agung Bagus Putra Indrakusuma |
| collection | DOAJ |
| description | Objectives: To investigate the association between the consumption of antipsychotic drugs and breast cancer. Methods: In this systematic review and meta-analysis study, relevant studies were extracted from different databases including PubMed, ScienceDirect, Cochrane, Medline, and additional sources. The selected studies were statistically analyzed and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: Of a total of 11 studies selected, five were case-control type and six were cohort type. The overall study quality was 6.7. Meta-analysis of the five case-control studies (which together had 81 766 breast cancer patients and 1 150 316 control participants) showed no significant association between the overall use of antipsychotic drugs and the incidence of breast cancer (odds ratio = 1.06; 95% CI: 0.94–1.19; p =0.36). Q-test results showed evidence of heterogeneity (p < 0.10) in the overall analysis. The I2 statistical assessment also show evidence of heterogeneity (I2> 75%). Conclusions: The use of antipsychotic drugs does not significantly increase the risk of breast cancer. |
| first_indexed | 2024-04-13T12:00:44Z |
| format | Article |
| id | doaj.art-a12c0c196faa425f8983fc86ec2de33d |
| institution | Directory Open Access Journal |
| issn | 1999-768X 2070-5204 |
| language | English |
| last_indexed | 2024-04-13T12:00:44Z |
| publishDate | 2022-11-01 |
| publisher | Oman Medical Specialty Board |
| record_format | Article |
| series | Oman Medical Journal |
| spelling | doaj.art-a12c0c196faa425f8983fc86ec2de33d2022-12-22T02:47:47ZengOman Medical Specialty BoardOman Medical Journal1999-768X2070-52042022-11-01376e453e45310.5001/omj.2022.71The Risk of Antipsychotic Drugs on Breast Cancer: A Systematic Review and Meta-analysisAnak Agung Bagus Putra Indrakusuma0 I Gede Krisna Arim Sadeva1I Gusti Ngurah Ananda Wira Kusuma 2Cokorda Bagus Jaya Lesmana3Desak Made Wihandani4Medical Faculty, Udayana University, Bali, IndonesiaMedical Faculty, Udayana University, Bali, IndonesiaMedical Faculty, Udayana University, Bali, IndonesiaPsychiatry Department, Medical Faculty, Udayana University, Bali, IndonesiaBiochemistry Department, Medical Faculty, Udayana University, Bali, IndonesiaObjectives: To investigate the association between the consumption of antipsychotic drugs and breast cancer. Methods: In this systematic review and meta-analysis study, relevant studies were extracted from different databases including PubMed, ScienceDirect, Cochrane, Medline, and additional sources. The selected studies were statistically analyzed and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: Of a total of 11 studies selected, five were case-control type and six were cohort type. The overall study quality was 6.7. Meta-analysis of the five case-control studies (which together had 81 766 breast cancer patients and 1 150 316 control participants) showed no significant association between the overall use of antipsychotic drugs and the incidence of breast cancer (odds ratio = 1.06; 95% CI: 0.94–1.19; p =0.36). Q-test results showed evidence of heterogeneity (p < 0.10) in the overall analysis. The I2 statistical assessment also show evidence of heterogeneity (I2> 75%). Conclusions: The use of antipsychotic drugs does not significantly increase the risk of breast cancer.https://omjournal.org/articleDetails.aspx?coType=1&aId=3279antipsychoticsbreast cancerrisksystematic reviewmeta-analysisindonesia |
| spellingShingle | Anak Agung Bagus Putra Indrakusuma I Gede Krisna Arim Sadeva I Gusti Ngurah Ananda Wira Kusuma Cokorda Bagus Jaya Lesmana Desak Made Wihandani The Risk of Antipsychotic Drugs on Breast Cancer: A Systematic Review and Meta-analysis Oman Medical Journal antipsychotics breast cancer risk systematic review meta-analysis indonesia |
| title | The Risk of Antipsychotic Drugs on Breast Cancer: A Systematic Review and Meta-analysis |
| title_full | The Risk of Antipsychotic Drugs on Breast Cancer: A Systematic Review and Meta-analysis |
| title_fullStr | The Risk of Antipsychotic Drugs on Breast Cancer: A Systematic Review and Meta-analysis |
| title_full_unstemmed | The Risk of Antipsychotic Drugs on Breast Cancer: A Systematic Review and Meta-analysis |
| title_short | The Risk of Antipsychotic Drugs on Breast Cancer: A Systematic Review and Meta-analysis |
| title_sort | risk of antipsychotic drugs on breast cancer a systematic review and meta analysis |
| topic | antipsychotics breast cancer risk systematic review meta-analysis indonesia |
| url | https://omjournal.org/articleDetails.aspx?coType=1&aId=3279 |
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