Anticonvulsive Effects of Chondroitin Sulfate on Pilocarpine and Pentylenetetrazole Induced Epileptogenesis in Mice

Anticonvulsive Effects of Chondroitin Sulfate on Pilocarpine and Pentylenetetrazole Induced Epileptogenesis in Mice

Chondroitin sulfate is a proteoglycan component of the extracellular matrix (ECM) that supports neuronal and non-neuronal cell activity, provides a negative domain to the extracellular matrix, regulates the intracellular positive ion concentration, and maintains the hypersynchronous epileptiform act...

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Bibliographic Details
Main Authors: Shareen Singh, Thakur Gurjeet Singh, Manjinder Singh, Agnieszka Najda, Renata Nurzyńska-Wierdak, Rafa Almeer, Mohamed Kamel, Mohamed M. Abdel-Daim
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Molecules
Subjects:
chondroitin sulfate
extracellular matrix
intracellular ionic concentration
caspase-3
pro-inflammatory mediators
oxidative stress
Online Access:https://www.mdpi.com/1420-3049/26/22/6773

Internet

https://www.mdpi.com/1420-3049/26/22/6773

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