Screening for renal cell carcinoma in renal transplant recipients: a single-centre retrospective study
Objectives The primary objective of our study was to evaluate the effectiveness of renal cell carcinoma (RCC) screening in renal transplant (RT) recipients.Design Single-centre retrospective study.Setting and participants 1998 RT recipients who underwent RT at Memorial Hermann Hospital (MHH) Texas M...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/9/e071658.full |
| _version_ | 1797669389727694848 |
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| author | Arthi Sridhar Binoy Yohannan Harmanpreet Kaur Aleksandra DeGolovine Neha Maithel |
| author_facet | Arthi Sridhar Binoy Yohannan Harmanpreet Kaur Aleksandra DeGolovine Neha Maithel |
| author_sort | Arthi Sridhar |
| collection | DOAJ |
| description | Objectives The primary objective of our study was to evaluate the effectiveness of renal cell carcinoma (RCC) screening in renal transplant (RT) recipients.Design Single-centre retrospective study.Setting and participants 1998 RT recipients who underwent RT at Memorial Hermann Hospital (MHH) Texas Medical Center (TMC) between 1 January 1999 and 31 December 2019 were included and we identified 16 patients (0.8%) with RCC. An additional four patients with RCC who underwent RT elsewhere but received follow-up at MHH TMC were also included. Subject races included white (20%), black (50%), Hispanic (20%) and Asian (10%).Outcome measures The RCC stage at diagnosis and outcomes were compared between patients who were screening versus those who were not.Results We identified a total of 20 patients with post-RT RCC, 75% of whom were men. The median age at diagnosis was 56 years. RCC histologies included clear cell (75%), papillary (20%) and chromophobe (5%). Patients with post-RT RCC who had screening (n=12) underwent ultrasound or CT annually or every 2 years, whereas eight patients had no screening. All 12 patients who had screening had early-stage disease at diagnosis (stage I (n=11) or stage II (n=1)) and were cured by nephrectomy (n=10) or cryotherapy (n=2). In patients who had no screening, three (37.5%) had stage IV RCC at diagnosis and all of whom died of metastatic disease. There was a statistically significant difference in RCC-specific survival in patients who were screened (p=0.01) compared with those who were not screened.Conclusion All RT recipients who had RCC diagnosed based on screening had early-stage disease and there were no RCC-related deaths. Screening is an effective intervention in RT recipients to reduce RCC-related mortality. |
| first_indexed | 2024-03-11T20:43:39Z |
| format | Article |
| id | doaj.art-a12c4933b03d46c09b2d40b26d6349a8 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-11T20:43:39Z |
| publishDate | 2023-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-a12c4933b03d46c09b2d40b26d6349a82023-10-01T22:40:07ZengBMJ Publishing GroupBMJ Open2044-60552023-09-0113910.1136/bmjopen-2023-071658Screening for renal cell carcinoma in renal transplant recipients: a single-centre retrospective studyArthi Sridhar0Binoy Yohannan1Harmanpreet Kaur2Aleksandra DeGolovine3Neha Maithel4Department of Hematology and Oncology, The University of Texas Health Sciences Center at Houston, Houston, Texas, USADepartment of Hematology and Oncology, The University of Texas Health Sciences Center at Houston, Houston, Texas, USADepartment of Internal Medicine, UT Southwestern Medical School, Dallas, Texas, USADepartment of Renal Disease and Hypertension, The University of Texas Health Sciences Center at Houston, Houston, Texas, USADepartment of Hematology and Oncology, The University of Texas Health Sciences Center at Houston, Houston, Texas, USAObjectives The primary objective of our study was to evaluate the effectiveness of renal cell carcinoma (RCC) screening in renal transplant (RT) recipients.Design Single-centre retrospective study.Setting and participants 1998 RT recipients who underwent RT at Memorial Hermann Hospital (MHH) Texas Medical Center (TMC) between 1 January 1999 and 31 December 2019 were included and we identified 16 patients (0.8%) with RCC. An additional four patients with RCC who underwent RT elsewhere but received follow-up at MHH TMC were also included. Subject races included white (20%), black (50%), Hispanic (20%) and Asian (10%).Outcome measures The RCC stage at diagnosis and outcomes were compared between patients who were screening versus those who were not.Results We identified a total of 20 patients with post-RT RCC, 75% of whom were men. The median age at diagnosis was 56 years. RCC histologies included clear cell (75%), papillary (20%) and chromophobe (5%). Patients with post-RT RCC who had screening (n=12) underwent ultrasound or CT annually or every 2 years, whereas eight patients had no screening. All 12 patients who had screening had early-stage disease at diagnosis (stage I (n=11) or stage II (n=1)) and were cured by nephrectomy (n=10) or cryotherapy (n=2). In patients who had no screening, three (37.5%) had stage IV RCC at diagnosis and all of whom died of metastatic disease. There was a statistically significant difference in RCC-specific survival in patients who were screened (p=0.01) compared with those who were not screened.Conclusion All RT recipients who had RCC diagnosed based on screening had early-stage disease and there were no RCC-related deaths. Screening is an effective intervention in RT recipients to reduce RCC-related mortality.https://bmjopen.bmj.com/content/13/9/e071658.full |
| spellingShingle | Arthi Sridhar Binoy Yohannan Harmanpreet Kaur Aleksandra DeGolovine Neha Maithel Screening for renal cell carcinoma in renal transplant recipients: a single-centre retrospective study BMJ Open |
| title | Screening for renal cell carcinoma in renal transplant recipients: a single-centre retrospective study |
| title_full | Screening for renal cell carcinoma in renal transplant recipients: a single-centre retrospective study |
| title_fullStr | Screening for renal cell carcinoma in renal transplant recipients: a single-centre retrospective study |
| title_full_unstemmed | Screening for renal cell carcinoma in renal transplant recipients: a single-centre retrospective study |
| title_short | Screening for renal cell carcinoma in renal transplant recipients: a single-centre retrospective study |
| title_sort | screening for renal cell carcinoma in renal transplant recipients a single centre retrospective study |
| url | https://bmjopen.bmj.com/content/13/9/e071658.full |
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