Endogenous mouse huntingtin is highly abundant in cranial nerve nuclei, co-aggregates to Abeta plaques and is induced in reactive astrocytes in a transgenic mouse model of Alzheimer’s disease

Endogenous mouse huntingtin is highly abundant in cranial nerve nuclei, co-aggregates to Abeta plaques and is induced in reactive astrocytes in a transgenic mouse model of Alzheimer’s disease

Abstract Pathogenic variants of the huntingtin (HTT) protein and their aggregation have been investigated in great detail in brains of Huntington’s disease patients and HTT-transgenic animals. However, little is known about the physiological brain region- and cell type-specific HTT expression patter...

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Bibliographic Details
Main Authors: Maike Hartlage-Rübsamen, Veronika Ratz, Ulrike Zeitschel, Lukas Finzel, Lisa Machner, Janett Köppen, Anja Schulze, Hans-Ulrich Demuth, Stephan von Hörsten, Corinna Höfling, Steffen Roßner
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Acta Neuropathologica Communications
Subjects:
Huntingtin
Cranial nerve nuclei
Alzheimer’s disease
Animal model
Amyloid precursor protein
Astrocytes
Online Access:http://link.springer.com/article/10.1186/s40478-019-0726-2

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