Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans.
Although organophosphorus pesticides (OP) share a common mode of action, there is increased awareness that they elicit a diverse range of gene expression responses. As yet however, there is no clear understanding of these responses and how they interact with ambient environmental conditions. In the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21931806/pdf/?tool=EBI |
| _version_ | 1818403402587045888 |
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| author | Ana Viñuela L Basten Snoek Joost A G Riksen Jan E Kammenga |
| author_facet | Ana Viñuela L Basten Snoek Joost A G Riksen Jan E Kammenga |
| author_sort | Ana Viñuela |
| collection | DOAJ |
| description | Although organophosphorus pesticides (OP) share a common mode of action, there is increased awareness that they elicit a diverse range of gene expression responses. As yet however, there is no clear understanding of these responses and how they interact with ambient environmental conditions. In the present study, we investigated genome-wide gene expression profiles in the nematode Caenorhabditis elegans exposed to two OP, chlorpyrifos and diazinon, in single and combined treatments at different temperatures. Our results show that chlorpyrifos and diazinon induced expression of different genes and that temperature affected the response of detoxification genes to the pesticides. The analysis of transcriptional responses to a combination of chlorpyrifos and diazinon shows interactions between toxicants that affect gene expression. Furthermore, our combined analysis of the transcriptional responses to OP at different temperatures suggests that the combination of OP and high temperatures affect detoxification genes and modified the toxic levels of the pesticides. |
| first_indexed | 2024-12-14T08:23:41Z |
| format | Article |
| id | doaj.art-a13158eaa03f4001bf20287382b02414 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T08:23:41Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a13158eaa03f4001bf20287382b024142022-12-21T23:09:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0169e2467610.1371/journal.pone.0024676Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans.Ana ViñuelaL Basten SnoekJoost A G RiksenJan E KammengaAlthough organophosphorus pesticides (OP) share a common mode of action, there is increased awareness that they elicit a diverse range of gene expression responses. As yet however, there is no clear understanding of these responses and how they interact with ambient environmental conditions. In the present study, we investigated genome-wide gene expression profiles in the nematode Caenorhabditis elegans exposed to two OP, chlorpyrifos and diazinon, in single and combined treatments at different temperatures. Our results show that chlorpyrifos and diazinon induced expression of different genes and that temperature affected the response of detoxification genes to the pesticides. The analysis of transcriptional responses to a combination of chlorpyrifos and diazinon shows interactions between toxicants that affect gene expression. Furthermore, our combined analysis of the transcriptional responses to OP at different temperatures suggests that the combination of OP and high temperatures affect detoxification genes and modified the toxic levels of the pesticides.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21931806/pdf/?tool=EBI |
| spellingShingle | Ana Viñuela L Basten Snoek Joost A G Riksen Jan E Kammenga Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans. PLoS ONE |
| title | Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans. |
| title_full | Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans. |
| title_fullStr | Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans. |
| title_full_unstemmed | Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans. |
| title_short | Gene expression modifications by temperature-toxicants interactions in Caenorhabditis elegans. |
| title_sort | gene expression modifications by temperature toxicants interactions in caenorhabditis elegans |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21931806/pdf/?tool=EBI |
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