Myosteatosis Differentially Affects the Prognosis of Non-Metastatic Colon and Rectal Cancer Patients: An Exploratory Study
Body composition performed by computed tomography (CT) impacts on cancer patients’ prognoses and responses to treatment. Myosteatosis has been related to overall survival (OS) and disease-specific survival in colorectal cancer (CRC); however, the independent impact of the association of myosteatosis...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.762444/full |
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| author | Lara Pozzuto Marina Nogueira Silveira Maria Carolina Santos Mendes Lígia Traldi Macedo Felipe Osório Costa Carlos Augusto Real Martinez Cláudio Saddy Rodrigues Coy Ademar Dantas da Cunha Júnior Ademar Dantas da Cunha Júnior José Barreto Campello Carvalheira |
| author_facet | Lara Pozzuto Marina Nogueira Silveira Maria Carolina Santos Mendes Lígia Traldi Macedo Felipe Osório Costa Carlos Augusto Real Martinez Cláudio Saddy Rodrigues Coy Ademar Dantas da Cunha Júnior Ademar Dantas da Cunha Júnior José Barreto Campello Carvalheira |
| author_sort | Lara Pozzuto |
| collection | DOAJ |
| description | Body composition performed by computed tomography (CT) impacts on cancer patients’ prognoses and responses to treatment. Myosteatosis has been related to overall survival (OS) and disease-specific survival in colorectal cancer (CRC); however, the independent impact of the association of myosteatosis with prognosis in colon cancer (CC) and rectal cancer (RC) is still unclear. CT was performed at the L3 level to assess body composition features in 227 patients with CRC. Clinical parameters were collected. Overall survival (OS) was the primary outcome, and the secondary outcome was disease-free survival (DFS). Skeletal muscle attenuation and intramuscular adipose tissue area were associated with DFS (p = 0.003 and p = 0.011, respectively) and OS (p < 0.001 and p < 0.001, respectively) in CC patients but not in RC patients. Only the skeletal muscle area was associated with better prognosis related to OS in RC patients (p = 0.009). When CC and RC were analyzed separately, myosteatosis influenced survival negatively in CC patients, worsening DFS survival (hazard ratio [HR], 2.70; 95% confidence interval [CI], 1.07–6.82; p = 0.035) and OS (HR, 5.76; 95% CI, 1.31–25.40; p = 0.021). By contrast, the presence of myosteatosis did not influence DFS (HR, 1.02; 95% CI, 0.52–2.03; p = 0.944) or OS (HR, 0.76; 95% CI, 0.33–1.77; p = 0.529) in RC patients. Our study revealed the interference of myosteatosis in the therapy and survival of patients with CC but not in those with RC, strengthening the value of grouping the two types of cancer in body composition analyses. |
| first_indexed | 2024-12-18T23:35:56Z |
| format | Article |
| id | doaj.art-a13324fbc0d84e45b21da93548d978df |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-18T23:35:56Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a13324fbc0d84e45b21da93548d978df2022-12-21T20:47:32ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-11-011110.3389/fonc.2021.762444762444Myosteatosis Differentially Affects the Prognosis of Non-Metastatic Colon and Rectal Cancer Patients: An Exploratory StudyLara Pozzuto0Marina Nogueira Silveira1Maria Carolina Santos Mendes2Lígia Traldi Macedo3Felipe Osório Costa4Carlos Augusto Real Martinez5Cláudio Saddy Rodrigues Coy6Ademar Dantas da Cunha Júnior7Ademar Dantas da Cunha Júnior8José Barreto Campello Carvalheira9Division of Oncology, Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, BrazilDivision of Oncology, Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, BrazilDivision of Oncology, Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, BrazilDivision of Oncology, Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, BrazilDivision of Oncology, Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, BrazilDivision of Gatrointestinal Surgery, Department of Surgery, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, BrazilDivision of Gatrointestinal Surgery, Department of Surgery, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, BrazilHematology and Oncology Clinics, Cancer Hospital of Cascavel, União Oeste de Estudos e Combate ao Câncer (UOPECCAN), Cascavel, BrazilDepartment of Internal Medicine, State University of Western Paraná (UNIOESTE), Cascavel, BrazilDivision of Oncology, Department of Anesthesiology, Oncology and Radiology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, BrazilBody composition performed by computed tomography (CT) impacts on cancer patients’ prognoses and responses to treatment. Myosteatosis has been related to overall survival (OS) and disease-specific survival in colorectal cancer (CRC); however, the independent impact of the association of myosteatosis with prognosis in colon cancer (CC) and rectal cancer (RC) is still unclear. CT was performed at the L3 level to assess body composition features in 227 patients with CRC. Clinical parameters were collected. Overall survival (OS) was the primary outcome, and the secondary outcome was disease-free survival (DFS). Skeletal muscle attenuation and intramuscular adipose tissue area were associated with DFS (p = 0.003 and p = 0.011, respectively) and OS (p < 0.001 and p < 0.001, respectively) in CC patients but not in RC patients. Only the skeletal muscle area was associated with better prognosis related to OS in RC patients (p = 0.009). When CC and RC were analyzed separately, myosteatosis influenced survival negatively in CC patients, worsening DFS survival (hazard ratio [HR], 2.70; 95% confidence interval [CI], 1.07–6.82; p = 0.035) and OS (HR, 5.76; 95% CI, 1.31–25.40; p = 0.021). By contrast, the presence of myosteatosis did not influence DFS (HR, 1.02; 95% CI, 0.52–2.03; p = 0.944) or OS (HR, 0.76; 95% CI, 0.33–1.77; p = 0.529) in RC patients. Our study revealed the interference of myosteatosis in the therapy and survival of patients with CC but not in those with RC, strengthening the value of grouping the two types of cancer in body composition analyses.https://www.frontiersin.org/articles/10.3389/fonc.2021.762444/fullskeletal muscle radiodensitycancersurvivalcomputerized tomographysarcopeniaskeletal muscle mass |
| spellingShingle | Lara Pozzuto Marina Nogueira Silveira Maria Carolina Santos Mendes Lígia Traldi Macedo Felipe Osório Costa Carlos Augusto Real Martinez Cláudio Saddy Rodrigues Coy Ademar Dantas da Cunha Júnior Ademar Dantas da Cunha Júnior José Barreto Campello Carvalheira Myosteatosis Differentially Affects the Prognosis of Non-Metastatic Colon and Rectal Cancer Patients: An Exploratory Study Frontiers in Oncology skeletal muscle radiodensity cancer survival computerized tomography sarcopenia skeletal muscle mass |
| title | Myosteatosis Differentially Affects the Prognosis of Non-Metastatic Colon and Rectal Cancer Patients: An Exploratory Study |
| title_full | Myosteatosis Differentially Affects the Prognosis of Non-Metastatic Colon and Rectal Cancer Patients: An Exploratory Study |
| title_fullStr | Myosteatosis Differentially Affects the Prognosis of Non-Metastatic Colon and Rectal Cancer Patients: An Exploratory Study |
| title_full_unstemmed | Myosteatosis Differentially Affects the Prognosis of Non-Metastatic Colon and Rectal Cancer Patients: An Exploratory Study |
| title_short | Myosteatosis Differentially Affects the Prognosis of Non-Metastatic Colon and Rectal Cancer Patients: An Exploratory Study |
| title_sort | myosteatosis differentially affects the prognosis of non metastatic colon and rectal cancer patients an exploratory study |
| topic | skeletal muscle radiodensity cancer survival computerized tomography sarcopenia skeletal muscle mass |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.762444/full |
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