Design, synthesis and antiproliferative evaluation of new acridine-thiosemicarbazone derivatives as topoisomerase IIα inhibitors

Design, synthesis and antiproliferative evaluation of new acridine-thiosemicarbazone derivatives as topoisomerase IIα inhibitors

Thiosemicarbazone-acridine hybrids are prominent inhibitors of topoisomerases II. This study reports the design, synthesis, and antiproliferative evaluation of eighteen new acridine–thiosemicarbazone derivatives as possible inhibitors of topoisomerase IIα. In general, compounds showed moderate to lo...

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Bibliographic Details
Main Authors: Gleyton Leonel Silva Sousa, Thiago da Silva Honório, Priscila de Souza Furtado, Alice Simon, Lucio Mendes Cabral, Gabriel Rodrigues Coutinho Pereira, Josival Emanuel Ferreira Alves, Sinara Mônica Vitalino de Almeida, Valdenizia Rodrigues Silva, Luciano de Souza Santos, Daniel Pereira Bezerra, Rosane Nora Castro, Ricardo Olímpio de Moura, Arthur Eugen Kümmerle
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Results in Chemistry
Subjects:
Acridine-thiosemicarbazone
Antiproliferative
Topoisomerase IIα
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715624000675

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