Association Between Vitamin D Levels and the Atherogenic Index of Plasma Among Chinese with Type 2 Diabetes Mellitus
Jiangli Ban,1,2 Xuetong Zhao,3 Zhuoya Jia,2,4 Zelin Li,2,4 Shuchun Chen2,4,5 1Graduate School of Hebei North University, Zhangjiakou, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 3Baoding NO.1 Hospital, Baoding, People’s...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-02-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/association-between-vitamin-d-levels-and-the-atherogenic-index-of-plas-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1797894473963798528 |
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| author | Ban J Zhao X Jia Z Li Z Chen S |
| author_facet | Ban J Zhao X Jia Z Li Z Chen S |
| author_sort | Ban J |
| collection | DOAJ |
| description | Jiangli Ban,1,2 Xuetong Zhao,3 Zhuoya Jia,2,4 Zelin Li,2,4 Shuchun Chen2,4,5 1Graduate School of Hebei North University, Zhangjiakou, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 3Baoding NO.1 Hospital, Baoding, People’s Republic of China; 4Graduate School of Hebei Medical University, Shijiazhuang, People’s Republic of China; 5Hebei Key Laboratory of Metabolic Diseases, Shijiazhuang, People’s Republic of ChinaCorrespondence: Shuchun Chen, Department of Endocrinology, Hebei General Hospital, 348 Heping West Road, Shijiazhuang, 050051, People’s Republic of China, Tel/Fax +86 31185988406, Email chenshuc2014@163.comPurpose: The relationship between atherogenic index of plasma (AIP) values and 25-hydroxyvitamin D (25[OH] D) was examined in type 2 diabetes mellitus (T2DM).Patients and Methods: Six hundred and ninety-eight T2DM patients were included. Patients were allocated to two groups, namely, the vitamin D-deficient and non-deficient groups (threshold of 20 ng/mL). The AIP was determined as log (TG [mmol/L] / HDL-C [mmol/L]). The patients were then allocated to two further groups according to the median AIP value.Results: AIP level in the vitamin D-deficient group was significantly higher than that in non-deficient group (P< 0.05). Patients with high AIP values had markedly reduced levels of vitamin D levels compared with those in the low-AIP group [15.89 (11.97, 20.29) VS 18.22 (13.89, 23.08), P< 0.001]. Patients in the high AIP group had a higher rate of vitamin D deficiency (73.3% VS 60.6%). It was found that AIP values were adversely and independently correlated with vitamin D levels. The AIP value was shown to independently predict vitamin D deficiency risk in T2DM patients.Conclusion: Patients with T2DM were shown to have an increased risk of vitamin D insufficiency when their AIP levels were low. This suggests that AIP is associated with vitamin D insufficiency in Chinese patients with type 2 diabetes.Keywords: vitamin D, diabetes mellitus, type 2 diabetes, atherogenic index of plasma |
| first_indexed | 2024-04-10T07:09:37Z |
| format | Article |
| id | doaj.art-a138142838fb4081afa08caabb02ef5d |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T07:09:37Z |
| publishDate | 2023-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-a138142838fb4081afa08caabb02ef5d2023-02-26T15:41:34ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072023-02-01Volume 1652353181820Association Between Vitamin D Levels and the Atherogenic Index of Plasma Among Chinese with Type 2 Diabetes MellitusBan JZhao XJia ZLi ZChen SJiangli Ban,1,2 Xuetong Zhao,3 Zhuoya Jia,2,4 Zelin Li,2,4 Shuchun Chen2,4,5 1Graduate School of Hebei North University, Zhangjiakou, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 3Baoding NO.1 Hospital, Baoding, People’s Republic of China; 4Graduate School of Hebei Medical University, Shijiazhuang, People’s Republic of China; 5Hebei Key Laboratory of Metabolic Diseases, Shijiazhuang, People’s Republic of ChinaCorrespondence: Shuchun Chen, Department of Endocrinology, Hebei General Hospital, 348 Heping West Road, Shijiazhuang, 050051, People’s Republic of China, Tel/Fax +86 31185988406, Email chenshuc2014@163.comPurpose: The relationship between atherogenic index of plasma (AIP) values and 25-hydroxyvitamin D (25[OH] D) was examined in type 2 diabetes mellitus (T2DM).Patients and Methods: Six hundred and ninety-eight T2DM patients were included. Patients were allocated to two groups, namely, the vitamin D-deficient and non-deficient groups (threshold of 20 ng/mL). The AIP was determined as log (TG [mmol/L] / HDL-C [mmol/L]). The patients were then allocated to two further groups according to the median AIP value.Results: AIP level in the vitamin D-deficient group was significantly higher than that in non-deficient group (P< 0.05). Patients with high AIP values had markedly reduced levels of vitamin D levels compared with those in the low-AIP group [15.89 (11.97, 20.29) VS 18.22 (13.89, 23.08), P< 0.001]. Patients in the high AIP group had a higher rate of vitamin D deficiency (73.3% VS 60.6%). It was found that AIP values were adversely and independently correlated with vitamin D levels. The AIP value was shown to independently predict vitamin D deficiency risk in T2DM patients.Conclusion: Patients with T2DM were shown to have an increased risk of vitamin D insufficiency when their AIP levels were low. This suggests that AIP is associated with vitamin D insufficiency in Chinese patients with type 2 diabetes.Keywords: vitamin D, diabetes mellitus, type 2 diabetes, atherogenic index of plasmahttps://www.dovepress.com/association-between-vitamin-d-levels-and-the-atherogenic-index-of-plas-peer-reviewed-fulltext-article-DMSOvitamin ddiabetes mellitustype 2 diabetesatherogenic index of plasma |
| spellingShingle | Ban J Zhao X Jia Z Li Z Chen S Association Between Vitamin D Levels and the Atherogenic Index of Plasma Among Chinese with Type 2 Diabetes Mellitus Diabetes, Metabolic Syndrome and Obesity vitamin d diabetes mellitus type 2 diabetes atherogenic index of plasma |
| title | Association Between Vitamin D Levels and the Atherogenic Index of Plasma Among Chinese with Type 2 Diabetes Mellitus |
| title_full | Association Between Vitamin D Levels and the Atherogenic Index of Plasma Among Chinese with Type 2 Diabetes Mellitus |
| title_fullStr | Association Between Vitamin D Levels and the Atherogenic Index of Plasma Among Chinese with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Association Between Vitamin D Levels and the Atherogenic Index of Plasma Among Chinese with Type 2 Diabetes Mellitus |
| title_short | Association Between Vitamin D Levels and the Atherogenic Index of Plasma Among Chinese with Type 2 Diabetes Mellitus |
| title_sort | association between vitamin d levels and the atherogenic index of plasma among chinese with type 2 diabetes mellitus |
| topic | vitamin d diabetes mellitus type 2 diabetes atherogenic index of plasma |
| url | https://www.dovepress.com/association-between-vitamin-d-levels-and-the-atherogenic-index-of-plas-peer-reviewed-fulltext-article-DMSO |
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