Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression
Cancer cells can use autophagy as a mechanism of surviving from external stresses. Here, the authors show that Pfkfb3, a glycolytic gene, is expressed in metastatic breast cancer cells but not in dormant cells that demonstrate features of autophagy.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11640-9 |
| _version_ | 1818433241518964736 |
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| author | Alyssa La Belle Flynn Benjamin C. Calhoun Arishya Sharma Jenny C. Chang Alexandru Almasan William P. Schiemann |
| author_facet | Alyssa La Belle Flynn Benjamin C. Calhoun Arishya Sharma Jenny C. Chang Alexandru Almasan William P. Schiemann |
| author_sort | Alyssa La Belle Flynn |
| collection | DOAJ |
| description | Cancer cells can use autophagy as a mechanism of surviving from external stresses. Here, the authors show that Pfkfb3, a glycolytic gene, is expressed in metastatic breast cancer cells but not in dormant cells that demonstrate features of autophagy. |
| first_indexed | 2024-12-14T16:17:58Z |
| format | Article |
| id | doaj.art-a138f0bd72854b59891da7dffc77c399 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:17:58Z |
| publishDate | 2019-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a138f0bd72854b59891da7dffc77c3992022-12-21T22:54:52ZengNature PortfolioNature Communications2041-17232019-08-0110111510.1038/s41467-019-11640-9Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expressionAlyssa La Belle Flynn0Benjamin C. Calhoun1Arishya Sharma2Jenny C. Chang3Alexandru Almasan4William P. Schiemann5Case Western Reserve University, Department of PharmacologyDepartment of Pathology and Laboratory Medicine, University of North CarolinaDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicHouston Methodist Research CenterDepartment of Cancer Biology, Lerner Research Institute, Cleveland ClinicCase Comprehensive Cancer Center, Case Western Reserve UniversityCancer cells can use autophagy as a mechanism of surviving from external stresses. Here, the authors show that Pfkfb3, a glycolytic gene, is expressed in metastatic breast cancer cells but not in dormant cells that demonstrate features of autophagy.https://doi.org/10.1038/s41467-019-11640-9 |
| spellingShingle | Alyssa La Belle Flynn Benjamin C. Calhoun Arishya Sharma Jenny C. Chang Alexandru Almasan William P. Schiemann Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression Nature Communications |
| title | Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression |
| title_full | Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression |
| title_fullStr | Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression |
| title_full_unstemmed | Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression |
| title_short | Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression |
| title_sort | autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing pfkfb3 expression |
| url | https://doi.org/10.1038/s41467-019-11640-9 |
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