Atypical presentation of polymorphous low-grade neuroepithelial tumor of young (PLNTY): a case report
Abstract The polymorphous low-grade neuroepithelial tumor of young (PLNTY) is considered as one among the low-grade neuroepithelial tumor; as per WHO-2021 classification of Brain Tumors in the fifth edition. The term PLNTY was first coined by Huse in 2016. These morphologically variable tumors are c...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2023-02-01
|
| Series: | Egyptian Journal of Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41984-023-00192-2 |
| _version_ | 1797865295802531840 |
|---|---|
| author | Vijay Joshi Meghana V. Chougule Anand Mudkanna Rakesh Kumar Mishra Ved Prakash Maurya Amit Agrawal |
| author_facet | Vijay Joshi Meghana V. Chougule Anand Mudkanna Rakesh Kumar Mishra Ved Prakash Maurya Amit Agrawal |
| author_sort | Vijay Joshi |
| collection | DOAJ |
| description | Abstract The polymorphous low-grade neuroepithelial tumor of young (PLNTY) is considered as one among the low-grade neuroepithelial tumor; as per WHO-2021 classification of Brain Tumors in the fifth edition. The term PLNTY was first coined by Huse in 2016. These morphologically variable tumors are characterized by their oligodendroglioma-like cellular components, infiltrative growth pattern, and Cluster of Differentiation 34 (CD34) immunopositivity. Frequent genetic abnormalities involving mitogen-activated protein kinase pathway constituents like the BRAF proto-oncogene or fibroblast growth receptor 2/3 are harbored by PLNTYs. Radiologically, these are found to be well-circumscribed lesions with calcified and cystic components, affecting primarily temporal lobes. Clinically, they present with seizures/epilepsy in young adults (< 30 years). In the present manuscript we are reporting a case of 37-year-old male, presenting with a gradually progressive headache for 6 months, found to have a left frontal multiloculated cystic lesion with dystrophic calcifications. Based on the distinctive histopathological feature of the oligodendroglioma-like infiltrative lesion showing CD34 immunopositivity, a diagnosis of a polymorphous low-grade neuroepithelial tumor of young was made. |
| first_indexed | 2024-04-09T23:06:31Z |
| format | Article |
| id | doaj.art-a1391c466ce5419d87518fcd881d4891 |
| institution | Directory Open Access Journal |
| issn | 2520-8225 |
| language | English |
| last_indexed | 2024-04-09T23:06:31Z |
| publishDate | 2023-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Neurosurgery |
| spelling | doaj.art-a1391c466ce5419d87518fcd881d48912023-03-22T10:42:06ZengSpringerOpenEgyptian Journal of Neurosurgery2520-82252023-02-013811610.1186/s41984-023-00192-2Atypical presentation of polymorphous low-grade neuroepithelial tumor of young (PLNTY): a case reportVijay Joshi0Meghana V. Chougule1Anand Mudkanna2Rakesh Kumar Mishra3Ved Prakash Maurya4Amit Agrawal5Sparsh Neuro and Superspeciality HospitalShant Pathology Laboratory and Cancer Diagnosis CentreSparsh Neuro and Superspeciality HospitalDepartment of Neurosurgery, Institute of Medical Sciences, Trauma Centre and Mahamana Centenary Superspeciality Hospital, Banaras Hindu UniversityDepartment of Neurosurgery, SGPGIMSDepartment of Neurosurgery, All India Institute of Medical SciencesAbstract The polymorphous low-grade neuroepithelial tumor of young (PLNTY) is considered as one among the low-grade neuroepithelial tumor; as per WHO-2021 classification of Brain Tumors in the fifth edition. The term PLNTY was first coined by Huse in 2016. These morphologically variable tumors are characterized by their oligodendroglioma-like cellular components, infiltrative growth pattern, and Cluster of Differentiation 34 (CD34) immunopositivity. Frequent genetic abnormalities involving mitogen-activated protein kinase pathway constituents like the BRAF proto-oncogene or fibroblast growth receptor 2/3 are harbored by PLNTYs. Radiologically, these are found to be well-circumscribed lesions with calcified and cystic components, affecting primarily temporal lobes. Clinically, they present with seizures/epilepsy in young adults (< 30 years). In the present manuscript we are reporting a case of 37-year-old male, presenting with a gradually progressive headache for 6 months, found to have a left frontal multiloculated cystic lesion with dystrophic calcifications. Based on the distinctive histopathological feature of the oligodendroglioma-like infiltrative lesion showing CD34 immunopositivity, a diagnosis of a polymorphous low-grade neuroepithelial tumor of young was made.https://doi.org/10.1186/s41984-023-00192-2Polymorphous low-grade neuroepithelial tumor of youngPLNTYCD34MAPK pathwayLow-grade epilepsy-associated tumors |
| spellingShingle | Vijay Joshi Meghana V. Chougule Anand Mudkanna Rakesh Kumar Mishra Ved Prakash Maurya Amit Agrawal Atypical presentation of polymorphous low-grade neuroepithelial tumor of young (PLNTY): a case report Egyptian Journal of Neurosurgery Polymorphous low-grade neuroepithelial tumor of young PLNTY CD34 MAPK pathway Low-grade epilepsy-associated tumors |
| title | Atypical presentation of polymorphous low-grade neuroepithelial tumor of young (PLNTY): a case report |
| title_full | Atypical presentation of polymorphous low-grade neuroepithelial tumor of young (PLNTY): a case report |
| title_fullStr | Atypical presentation of polymorphous low-grade neuroepithelial tumor of young (PLNTY): a case report |
| title_full_unstemmed | Atypical presentation of polymorphous low-grade neuroepithelial tumor of young (PLNTY): a case report |
| title_short | Atypical presentation of polymorphous low-grade neuroepithelial tumor of young (PLNTY): a case report |
| title_sort | atypical presentation of polymorphous low grade neuroepithelial tumor of young plnty a case report |
| topic | Polymorphous low-grade neuroepithelial tumor of young PLNTY CD34 MAPK pathway Low-grade epilepsy-associated tumors |
| url | https://doi.org/10.1186/s41984-023-00192-2 |
| work_keys_str_mv | AT vijayjoshi atypicalpresentationofpolymorphouslowgradeneuroepithelialtumorofyoungplntyacasereport AT meghanavchougule atypicalpresentationofpolymorphouslowgradeneuroepithelialtumorofyoungplntyacasereport AT anandmudkanna atypicalpresentationofpolymorphouslowgradeneuroepithelialtumorofyoungplntyacasereport AT rakeshkumarmishra atypicalpresentationofpolymorphouslowgradeneuroepithelialtumorofyoungplntyacasereport AT vedprakashmaurya atypicalpresentationofpolymorphouslowgradeneuroepithelialtumorofyoungplntyacasereport AT amitagrawal atypicalpresentationofpolymorphouslowgradeneuroepithelialtumorofyoungplntyacasereport |