Does regulation hold the key to optimizing lipopeptide production in Pseudomonas for biotechnology?
Lipopeptides (LPs) produced by Pseudomonas spp. are specialized metabolites with diverse structures and functions, including powerful biosurfactant and antimicrobial properties. Despite their enormous potential in environmental and industrial biotechnology, low yield and high production cost limit t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1363183/full |
| _version_ | 1797293803199004672 |
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| author | Lu Zhou Monica Höfte Rosanna C. Hennessy |
| author_facet | Lu Zhou Monica Höfte Rosanna C. Hennessy |
| author_sort | Lu Zhou |
| collection | DOAJ |
| description | Lipopeptides (LPs) produced by Pseudomonas spp. are specialized metabolites with diverse structures and functions, including powerful biosurfactant and antimicrobial properties. Despite their enormous potential in environmental and industrial biotechnology, low yield and high production cost limit their practical use. While genome mining and functional genomics have identified a multitude of LP biosynthetic gene clusters, the regulatory mechanisms underlying their biosynthesis remain poorly understood. We propose that regulation holds the key to unlocking LP production in Pseudomonas for biotechnology. In this review, we summarize the structure and function of Pseudomonas-derived LPs and describe the molecular basis for their biosynthesis and regulation. We examine the global and specific regulator-driven mechanisms controlling LP synthesis including the influence of environmental signals. Understanding LP regulation is key to modulating production of these valuable compounds, both quantitatively and qualitatively, for industrial and environmental biotechnology. |
| first_indexed | 2024-03-07T21:21:08Z |
| format | Article |
| id | doaj.art-a13a09bd0bcd4b78a76d1240efb4095d |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-07T21:21:08Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-a13a09bd0bcd4b78a76d1240efb4095d2024-02-27T12:03:48ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-02-011210.3389/fbioe.2024.13631831363183Does regulation hold the key to optimizing lipopeptide production in Pseudomonas for biotechnology?Lu Zhou0Monica Höfte1Rosanna C. Hennessy2Laboratory of Phytopathology, Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent University, Ghent, BelgiumLaboratory of Phytopathology, Department of Plants and Crops, Faculty of Bioscience Engineering, Ghent University, Ghent, BelgiumDepartment of Plant and Environmental Sciences, University of Copenhagen, Copenhagen, DenmarkLipopeptides (LPs) produced by Pseudomonas spp. are specialized metabolites with diverse structures and functions, including powerful biosurfactant and antimicrobial properties. Despite their enormous potential in environmental and industrial biotechnology, low yield and high production cost limit their practical use. While genome mining and functional genomics have identified a multitude of LP biosynthetic gene clusters, the regulatory mechanisms underlying their biosynthesis remain poorly understood. We propose that regulation holds the key to unlocking LP production in Pseudomonas for biotechnology. In this review, we summarize the structure and function of Pseudomonas-derived LPs and describe the molecular basis for their biosynthesis and regulation. We examine the global and specific regulator-driven mechanisms controlling LP synthesis including the influence of environmental signals. Understanding LP regulation is key to modulating production of these valuable compounds, both quantitatively and qualitatively, for industrial and environmental biotechnology.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1363183/fullPseudomonasspecialized metaboliteslipopeptidesbiosurfactantsantibioticsregulation |
| spellingShingle | Lu Zhou Monica Höfte Rosanna C. Hennessy Does regulation hold the key to optimizing lipopeptide production in Pseudomonas for biotechnology? Frontiers in Bioengineering and Biotechnology Pseudomonas specialized metabolites lipopeptides biosurfactants antibiotics regulation |
| title | Does regulation hold the key to optimizing lipopeptide production in Pseudomonas for biotechnology? |
| title_full | Does regulation hold the key to optimizing lipopeptide production in Pseudomonas for biotechnology? |
| title_fullStr | Does regulation hold the key to optimizing lipopeptide production in Pseudomonas for biotechnology? |
| title_full_unstemmed | Does regulation hold the key to optimizing lipopeptide production in Pseudomonas for biotechnology? |
| title_short | Does regulation hold the key to optimizing lipopeptide production in Pseudomonas for biotechnology? |
| title_sort | does regulation hold the key to optimizing lipopeptide production in pseudomonas for biotechnology |
| topic | Pseudomonas specialized metabolites lipopeptides biosurfactants antibiotics regulation |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1363183/full |
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