New Sulfamethoxazole Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors: Design, Synthesis, Cytotoxic Activity and Molecular Modeling

New Sulfamethoxazole Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors: Design, Synthesis, Cytotoxic Activity and Molecular Modeling

In this study new sulphamethoxazole derivatives (<b>S1<b>–</b>S4</b>, <b>S6<b>–</b>S12</b>, and <b>S14<b>–</b>S22</b>) were designed and synthesized and their structures were fully characterized and validated using NMR, mass, an...

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Bibliographic Details
Main Authors: Mohamed A. Abdelgawad, Syed N. A. Bukhari, Arafa Musa, Mohammed Elmowafy, Mohammed H. Elkomy, AbdElAziz. A. Nayl, Ahmed H. El-Ghorab, Ibrahim Hotan Alsohaimi, Mohamed Sadek Abdel-Bakky, Ibrahim O. Althobaiti, Hamud A. Altaleb, Hany A. Omar, Ahmed H. Abdelazeem, Mohamed A. Zaki, Mohamed E. Shaker, Heba A. H. Elshemy
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Pharmaceuticals
Subjects:
carbonic anhydrase
anticancer
sulfamethoxazole
apoptosis
molecular docking
Online Access:https://www.mdpi.com/1424-8247/15/9/1134

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