Neuronal Hyperactivation in EEG Data during Cognitive Tasks Is Related to the Apolipoprotein J/Clusterin Genotype in Nondemented Adults

Neuronal Hyperactivation in EEG Data during Cognitive Tasks Is Related to the Apolipoprotein J/Clusterin Genotype in Nondemented Adults

The clusterin (<i>CLU</i>) rs11136000 <i>CC</i> genotype is a probable risk factor for Alzheimer’s disease (AD). <i>CLU</i>, also known as the apolipoprotein <i>J</i> gene, shares certain properties with the apolipoprotein E (<i>APOE</i>) g...

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Bibliographic Details
Main Authors: Natalya V. Ponomareva, Tatiana V. Andreeva, Maria S. Protasova, Svetlana S. Kunizheva, Irina L. Kuznetsova, Ekaterina P. Kolesnikova, Daria D. Malina, Andrey A. Mitrofanov, Vitaly F. Fokin, Sergey N. Illarioshkin, Evgeny I. Rogaev
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
genetic predisposition
<i>CLU</i> genotype
EEG
event-related-desynchronization
verbal fluency
Online Access:https://www.mdpi.com/1422-0067/24/7/6790
Description
Summary:The clusterin (<i>CLU</i>) rs11136000 <i>CC</i> genotype is a probable risk factor for Alzheimer’s disease (AD). <i>CLU</i>, also known as the apolipoprotein <i>J</i> gene, shares certain properties with the apolipoprotein E (<i>APOE</i>) gene with a well-established relationship with AD. This study aimed to determine whether the electrophysiological patterns of brain activation during the letter fluency task (LFT) depend on <i>CLU</i> genotypes in adults without dementia. Previous studies have shown that LFT performance involves activation of the frontal cortex. We examined EEG alpha1 and alpha2 band desynchronization in the frontal regions during the LFT in 94 nondemented individuals stratified by <i>CLU</i> (rs11136000) genotype. Starting at 30 years of age, <i>CLU CC</i> carriers exhibited more pronounced task-related alpha2 desynchronization than <i>CLU CT&TT</i> carriers in the absence of any differences in LFT performance. In <i>CLU CC</i> carriers, alpha2 desynchronization was significantly correlated with age. Increased task-related activation in individuals at genetic risk for AD may reflect greater “effort” to perform the task and/or neuronal hyperexcitability. The results show that the <i>CLU</i> genotype is associated with neuronal hyperactivation in the frontal cortex during cognitive tasks performances in nondemented individuals, suggesting systematic vulnerability of LFT related cognitive networks in people carrying unfavorable <i>CLU</i> alleles.
ISSN:1661-6596
1422-0067

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