Neuronal Hyperactivation in EEG Data during Cognitive Tasks Is Related to the Apolipoprotein J/Clusterin Genotype in Nondemented Adults
The clusterin (<i>CLU</i>) rs11136000 <i>CC</i> genotype is a probable risk factor for Alzheimer’s disease (AD). <i>CLU</i>, also known as the apolipoprotein <i>J</i> gene, shares certain properties with the apolipoprotein E (<i>APOE</i>) g...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/7/6790 |
| _version_ | 1797607753382887424 |
|---|---|
| author | Natalya V. Ponomareva Tatiana V. Andreeva Maria S. Protasova Svetlana S. Kunizheva Irina L. Kuznetsova Ekaterina P. Kolesnikova Daria D. Malina Andrey A. Mitrofanov Vitaly F. Fokin Sergey N. Illarioshkin Evgeny I. Rogaev |
| author_facet | Natalya V. Ponomareva Tatiana V. Andreeva Maria S. Protasova Svetlana S. Kunizheva Irina L. Kuznetsova Ekaterina P. Kolesnikova Daria D. Malina Andrey A. Mitrofanov Vitaly F. Fokin Sergey N. Illarioshkin Evgeny I. Rogaev |
| author_sort | Natalya V. Ponomareva |
| collection | DOAJ |
| description | The clusterin (<i>CLU</i>) rs11136000 <i>CC</i> genotype is a probable risk factor for Alzheimer’s disease (AD). <i>CLU</i>, also known as the apolipoprotein <i>J</i> gene, shares certain properties with the apolipoprotein E (<i>APOE</i>) gene with a well-established relationship with AD. This study aimed to determine whether the electrophysiological patterns of brain activation during the letter fluency task (LFT) depend on <i>CLU</i> genotypes in adults without dementia. Previous studies have shown that LFT performance involves activation of the frontal cortex. We examined EEG alpha1 and alpha2 band desynchronization in the frontal regions during the LFT in 94 nondemented individuals stratified by <i>CLU</i> (rs11136000) genotype. Starting at 30 years of age, <i>CLU CC</i> carriers exhibited more pronounced task-related alpha2 desynchronization than <i>CLU CT&TT</i> carriers in the absence of any differences in LFT performance. In <i>CLU CC</i> carriers, alpha2 desynchronization was significantly correlated with age. Increased task-related activation in individuals at genetic risk for AD may reflect greater “effort” to perform the task and/or neuronal hyperexcitability. The results show that the <i>CLU</i> genotype is associated with neuronal hyperactivation in the frontal cortex during cognitive tasks performances in nondemented individuals, suggesting systematic vulnerability of LFT related cognitive networks in people carrying unfavorable <i>CLU</i> alleles. |
| first_indexed | 2024-03-11T05:34:02Z |
| format | Article |
| id | doaj.art-a13f794a9eb14b48adad899c164fcf89 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T05:34:02Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a13f794a9eb14b48adad899c164fcf892023-11-17T16:56:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01247679010.3390/ijms24076790Neuronal Hyperactivation in EEG Data during Cognitive Tasks Is Related to the Apolipoprotein J/Clusterin Genotype in Nondemented AdultsNatalya V. Ponomareva0Tatiana V. Andreeva1Maria S. Protasova2Svetlana S. Kunizheva3Irina L. Kuznetsova4Ekaterina P. Kolesnikova5Daria D. Malina6Andrey A. Mitrofanov7Vitaly F. Fokin8Sergey N. Illarioshkin9Evgeny I. Rogaev10Research Center of Neurology, 125367 Moscow, RussiaCenter for Genetics and Life Science, Sirius University of Science and Technology, 354349 Sochi, RussiaVavilov Institute of General Genetics, Russian Academy of Sciences, 119991 Moscow, RussiaCenter for Genetics and Life Science, Sirius University of Science and Technology, 354349 Sochi, RussiaCenter for Genetics and Life Science, Sirius University of Science and Technology, 354349 Sochi, RussiaResearch Center of Neurology, 125367 Moscow, RussiaResearch Center of Neurology, 125367 Moscow, RussiaResearch Center of Mental Health, 115522 Moscow, RussiaResearch Center of Neurology, 125367 Moscow, RussiaResearch Center of Neurology, 125367 Moscow, RussiaCenter for Genetics and Life Science, Sirius University of Science and Technology, 354349 Sochi, RussiaThe clusterin (<i>CLU</i>) rs11136000 <i>CC</i> genotype is a probable risk factor for Alzheimer’s disease (AD). <i>CLU</i>, also known as the apolipoprotein <i>J</i> gene, shares certain properties with the apolipoprotein E (<i>APOE</i>) gene with a well-established relationship with AD. This study aimed to determine whether the electrophysiological patterns of brain activation during the letter fluency task (LFT) depend on <i>CLU</i> genotypes in adults without dementia. Previous studies have shown that LFT performance involves activation of the frontal cortex. We examined EEG alpha1 and alpha2 band desynchronization in the frontal regions during the LFT in 94 nondemented individuals stratified by <i>CLU</i> (rs11136000) genotype. Starting at 30 years of age, <i>CLU CC</i> carriers exhibited more pronounced task-related alpha2 desynchronization than <i>CLU CT&TT</i> carriers in the absence of any differences in LFT performance. In <i>CLU CC</i> carriers, alpha2 desynchronization was significantly correlated with age. Increased task-related activation in individuals at genetic risk for AD may reflect greater “effort” to perform the task and/or neuronal hyperexcitability. The results show that the <i>CLU</i> genotype is associated with neuronal hyperactivation in the frontal cortex during cognitive tasks performances in nondemented individuals, suggesting systematic vulnerability of LFT related cognitive networks in people carrying unfavorable <i>CLU</i> alleles.https://www.mdpi.com/1422-0067/24/7/6790Alzheimer’s diseasegenetic predisposition<i>CLU</i> genotypeEEGevent-related-desynchronizationverbal fluency |
| spellingShingle | Natalya V. Ponomareva Tatiana V. Andreeva Maria S. Protasova Svetlana S. Kunizheva Irina L. Kuznetsova Ekaterina P. Kolesnikova Daria D. Malina Andrey A. Mitrofanov Vitaly F. Fokin Sergey N. Illarioshkin Evgeny I. Rogaev Neuronal Hyperactivation in EEG Data during Cognitive Tasks Is Related to the Apolipoprotein J/Clusterin Genotype in Nondemented Adults International Journal of Molecular Sciences Alzheimer’s disease genetic predisposition <i>CLU</i> genotype EEG event-related-desynchronization verbal fluency |
| title | Neuronal Hyperactivation in EEG Data during Cognitive Tasks Is Related to the Apolipoprotein J/Clusterin Genotype in Nondemented Adults |
| title_full | Neuronal Hyperactivation in EEG Data during Cognitive Tasks Is Related to the Apolipoprotein J/Clusterin Genotype in Nondemented Adults |
| title_fullStr | Neuronal Hyperactivation in EEG Data during Cognitive Tasks Is Related to the Apolipoprotein J/Clusterin Genotype in Nondemented Adults |
| title_full_unstemmed | Neuronal Hyperactivation in EEG Data during Cognitive Tasks Is Related to the Apolipoprotein J/Clusterin Genotype in Nondemented Adults |
| title_short | Neuronal Hyperactivation in EEG Data during Cognitive Tasks Is Related to the Apolipoprotein J/Clusterin Genotype in Nondemented Adults |
| title_sort | neuronal hyperactivation in eeg data during cognitive tasks is related to the apolipoprotein j clusterin genotype in nondemented adults |
| topic | Alzheimer’s disease genetic predisposition <i>CLU</i> genotype EEG event-related-desynchronization verbal fluency |
| url | https://www.mdpi.com/1422-0067/24/7/6790 |
| work_keys_str_mv | AT natalyavponomareva neuronalhyperactivationineegdataduringcognitivetasksisrelatedtotheapolipoproteinjclusteringenotypeinnondementedadults AT tatianavandreeva neuronalhyperactivationineegdataduringcognitivetasksisrelatedtotheapolipoproteinjclusteringenotypeinnondementedadults AT mariasprotasova neuronalhyperactivationineegdataduringcognitivetasksisrelatedtotheapolipoproteinjclusteringenotypeinnondementedadults AT svetlanaskunizheva neuronalhyperactivationineegdataduringcognitivetasksisrelatedtotheapolipoproteinjclusteringenotypeinnondementedadults AT irinalkuznetsova neuronalhyperactivationineegdataduringcognitivetasksisrelatedtotheapolipoproteinjclusteringenotypeinnondementedadults AT ekaterinapkolesnikova neuronalhyperactivationineegdataduringcognitivetasksisrelatedtotheapolipoproteinjclusteringenotypeinnondementedadults AT dariadmalina neuronalhyperactivationineegdataduringcognitivetasksisrelatedtotheapolipoproteinjclusteringenotypeinnondementedadults AT andreyamitrofanov neuronalhyperactivationineegdataduringcognitivetasksisrelatedtotheapolipoproteinjclusteringenotypeinnondementedadults AT vitalyffokin neuronalhyperactivationineegdataduringcognitivetasksisrelatedtotheapolipoproteinjclusteringenotypeinnondementedadults AT sergeynillarioshkin neuronalhyperactivationineegdataduringcognitivetasksisrelatedtotheapolipoproteinjclusteringenotypeinnondementedadults AT evgenyirogaev neuronalhyperactivationineegdataduringcognitivetasksisrelatedtotheapolipoproteinjclusteringenotypeinnondementedadults |