Relationship among <i>Streptococcus gallolyticus</i> Subsp. <i>gallolyticus</i>, <i>Enterococcus faecalis</i> and Colorectal Neoplasms in Recurrent Endocarditis: A Historical Case Series
Objectives: The role of colorectal neoplasms (CRN) as a common potential source of recurrent <i>Streptococcus gallolyticus</i> subsp. <i>gallolyticus</i> (SGG) and <i>Enterococcus faecalis</i> (EF) endocarditis remains unstudied. We aimed to investigate what propo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/8/2181 |
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| author | Eva Romay Juan Manuel Pericàs María José García-País Marta Hernández-Meneses Blanca Ayuso Javier García-González Rodrigo Vicente Garcés-Durán Ramón Rabuñal Pilar Alonso-García Fernando García-Garrote Andrés Perissinotti Bàrbara Vidal Carles Falces Eduard Quintana Leticia Moreira Manel Almela Josep Llach Asunción Moreno Juan Corredoira Jose María Miró on behalf of Lucus Augusti and Hospital Clinic Endocarditis Teams |
| author_facet | Eva Romay Juan Manuel Pericàs María José García-País Marta Hernández-Meneses Blanca Ayuso Javier García-González Rodrigo Vicente Garcés-Durán Ramón Rabuñal Pilar Alonso-García Fernando García-Garrote Andrés Perissinotti Bàrbara Vidal Carles Falces Eduard Quintana Leticia Moreira Manel Almela Josep Llach Asunción Moreno Juan Corredoira Jose María Miró on behalf of Lucus Augusti and Hospital Clinic Endocarditis Teams |
| author_sort | Eva Romay |
| collection | DOAJ |
| description | Objectives: The role of colorectal neoplasms (CRN) as a common potential source of recurrent <i>Streptococcus gallolyticus</i> subsp. <i>gallolyticus</i> (SGG) and <i>Enterococcus faecalis</i> (EF) endocarditis remains unstudied. We aimed to investigate what proportion of episodes of recurrent endocarditis are caused by a succession of SGG and EF, or vice versa, and to assess the role of a colonic source in such recurrent episodes. Methods: we conducted a retrospective analysis of two prospective endocarditis cohorts (1979–2019) from two Spanish hospitals, providing descriptive analyses of the major features of the endocarditis episodes, colonoscopy findings, and histologic results. Results: among 1552 IE episodes, 204 (13.1%) were caused by EF and 197 (12.7%) by SGG, respectively. There were 155 episodes (10%) of recurrent IE, 20 of which (12.9%) were due to a succession of SGG/EF IE in 10 patients (the first episode caused by SGG in eight cases, and by EF in two cases). The median follow-up was 86 (interquartile range 34–156) months. In 8/10 initial episodes, the causative microorganism was SGG, and all patients were diagnosed with CRN either during the initial episode or during follow-up. During the second episode of IE or follow-up, colonoscopies revealed CRN in six patients. Conclusions: There seems to be an association between SGG and EF in recurrent endocarditis that warrants further investigation. Our findings reinforce the need for systematically performing colonoscopy in the event of endocarditis caused by both microorganisms. |
| first_indexed | 2024-03-09T13:29:26Z |
| format | Article |
| id | doaj.art-a14032c8b20c4cf9bdea83915090b2cf |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T13:29:26Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a14032c8b20c4cf9bdea83915090b2cf2023-11-30T21:19:31ZengMDPI AGJournal of Clinical Medicine2077-03832022-04-01118218110.3390/jcm11082181Relationship among <i>Streptococcus gallolyticus</i> Subsp. <i>gallolyticus</i>, <i>Enterococcus faecalis</i> and Colorectal Neoplasms in Recurrent Endocarditis: A Historical Case SeriesEva Romay0Juan Manuel Pericàs1María José García-País2Marta Hernández-Meneses3Blanca Ayuso4Javier García-González5Rodrigo Vicente Garcés-Durán6Ramón Rabuñal7Pilar Alonso-García8Fernando García-Garrote9Andrés Perissinotti10Bàrbara Vidal11Carles Falces12Eduard Quintana13Leticia Moreira14Manel Almela15Josep Llach16Asunción Moreno17Juan Corredoira18Jose María Miró19on behalf of Lucus Augusti and Hospital Clinic Endocarditis TeamsInfectious Diseases Department, Hospital Lucus Augusti, 27003 Lugo, SpainInfectious Diseases Department, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques Pi i Sunyer, University of Barcelona, 08036 Barcelona, SpainInfectious Diseases Department, Hospital Lucus Augusti, 27003 Lugo, SpainInfectious Diseases Department, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques Pi i Sunyer, University of Barcelona, 08036 Barcelona, SpainInfectious Diseases Department, Hospital Lucus Augusti, 27003 Lugo, SpainInfectious Diseases Department, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques Pi i Sunyer, University of Barcelona, 08036 Barcelona, SpainGastroenterology Service, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d’Investigacions Biomèdiques Pi i Sunyer, University of Barcelona, 08036 Barcelona, SpainInfectious Diseases Department, Hospital Lucus Augusti, 27003 Lugo, SpainInfectious Diseases Department, Hospital Lucus Augusti, 27003 Lugo, SpainInfectious Diseases Department, Hospital Lucus Augusti, 27003 Lugo, SpainNuclear Medicine Department, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques Pi i Sunyer, Biomedical Research Networking Center of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 08036 Barcelona, SpainCardiology Department, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques Pi i Sunyer, University of Barcelona, 08036 Barcelona, SpainCardiology Department, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques Pi i Sunyer, University of Barcelona, 08036 Barcelona, SpainCardiovascular Surgery Department, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques Pi i Sunyer, University of Barcelona, 08036 Barcelona, SpainGastroenterology Service, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d’Investigacions Biomèdiques Pi i Sunyer, University of Barcelona, 08036 Barcelona, SpainMicrobiology Department, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques Pi i Sunyer, University of Barcelona, 08036 Barcelona, SpainGastroenterology Service, Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d’Investigacions Biomèdiques Pi i Sunyer, University of Barcelona, 08036 Barcelona, SpainInfectious Diseases Department, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques Pi i Sunyer, University of Barcelona, 08036 Barcelona, SpainInfectious Diseases Department, Hospital Lucus Augusti, 27003 Lugo, SpainInfectious Diseases Department, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques Pi i Sunyer, University of Barcelona, 08036 Barcelona, SpainObjectives: The role of colorectal neoplasms (CRN) as a common potential source of recurrent <i>Streptococcus gallolyticus</i> subsp. <i>gallolyticus</i> (SGG) and <i>Enterococcus faecalis</i> (EF) endocarditis remains unstudied. We aimed to investigate what proportion of episodes of recurrent endocarditis are caused by a succession of SGG and EF, or vice versa, and to assess the role of a colonic source in such recurrent episodes. Methods: we conducted a retrospective analysis of two prospective endocarditis cohorts (1979–2019) from two Spanish hospitals, providing descriptive analyses of the major features of the endocarditis episodes, colonoscopy findings, and histologic results. Results: among 1552 IE episodes, 204 (13.1%) were caused by EF and 197 (12.7%) by SGG, respectively. There were 155 episodes (10%) of recurrent IE, 20 of which (12.9%) were due to a succession of SGG/EF IE in 10 patients (the first episode caused by SGG in eight cases, and by EF in two cases). The median follow-up was 86 (interquartile range 34–156) months. In 8/10 initial episodes, the causative microorganism was SGG, and all patients were diagnosed with CRN either during the initial episode or during follow-up. During the second episode of IE or follow-up, colonoscopies revealed CRN in six patients. Conclusions: There seems to be an association between SGG and EF in recurrent endocarditis that warrants further investigation. Our findings reinforce the need for systematically performing colonoscopy in the event of endocarditis caused by both microorganisms.https://www.mdpi.com/2077-0383/11/8/2181infective endocarditis<i>Enterococcus faecalis</i><i>Streptococcus gallolyticus</i>recurrencesreinfectionscolorectal neoplasms |
| spellingShingle | Eva Romay Juan Manuel Pericàs María José García-País Marta Hernández-Meneses Blanca Ayuso Javier García-González Rodrigo Vicente Garcés-Durán Ramón Rabuñal Pilar Alonso-García Fernando García-Garrote Andrés Perissinotti Bàrbara Vidal Carles Falces Eduard Quintana Leticia Moreira Manel Almela Josep Llach Asunción Moreno Juan Corredoira Jose María Miró on behalf of Lucus Augusti and Hospital Clinic Endocarditis Teams Relationship among <i>Streptococcus gallolyticus</i> Subsp. <i>gallolyticus</i>, <i>Enterococcus faecalis</i> and Colorectal Neoplasms in Recurrent Endocarditis: A Historical Case Series Journal of Clinical Medicine infective endocarditis <i>Enterococcus faecalis</i> <i>Streptococcus gallolyticus</i> recurrences reinfections colorectal neoplasms |
| title | Relationship among <i>Streptococcus gallolyticus</i> Subsp. <i>gallolyticus</i>, <i>Enterococcus faecalis</i> and Colorectal Neoplasms in Recurrent Endocarditis: A Historical Case Series |
| title_full | Relationship among <i>Streptococcus gallolyticus</i> Subsp. <i>gallolyticus</i>, <i>Enterococcus faecalis</i> and Colorectal Neoplasms in Recurrent Endocarditis: A Historical Case Series |
| title_fullStr | Relationship among <i>Streptococcus gallolyticus</i> Subsp. <i>gallolyticus</i>, <i>Enterococcus faecalis</i> and Colorectal Neoplasms in Recurrent Endocarditis: A Historical Case Series |
| title_full_unstemmed | Relationship among <i>Streptococcus gallolyticus</i> Subsp. <i>gallolyticus</i>, <i>Enterococcus faecalis</i> and Colorectal Neoplasms in Recurrent Endocarditis: A Historical Case Series |
| title_short | Relationship among <i>Streptococcus gallolyticus</i> Subsp. <i>gallolyticus</i>, <i>Enterococcus faecalis</i> and Colorectal Neoplasms in Recurrent Endocarditis: A Historical Case Series |
| title_sort | relationship among i streptococcus gallolyticus i subsp i gallolyticus i i enterococcus faecalis i and colorectal neoplasms in recurrent endocarditis a historical case series |
| topic | infective endocarditis <i>Enterococcus faecalis</i> <i>Streptococcus gallolyticus</i> recurrences reinfections colorectal neoplasms |
| url | https://www.mdpi.com/2077-0383/11/8/2181 |
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