Characteristics of sleep-disordered breathing in children with down syndrome - A comparison with typically developing children
Background: Compared with typically developing control children (CC), children with Down syndrome (DS) frequently exhibit sleep-disordered breathing (SDB) and unusual sleep postures (USPs). No studies have directly compared SDB-related signs and symptoms, SDB-related parameters, and USPs between chi...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
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| Series: | Sleep Medicine: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590142722000040 |
| _version_ | 1818256193007648768 |
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| author | Hiroyuki Sawatari Anita Rahmawati Nobuko Moriyama Kanae Fujita Tomoko Ohkusa Tomoko Nao Nobuko Hashiguchi Mari Nishizaka Shin-ichi Ando Akiko Chishaki |
| author_facet | Hiroyuki Sawatari Anita Rahmawati Nobuko Moriyama Kanae Fujita Tomoko Ohkusa Tomoko Nao Nobuko Hashiguchi Mari Nishizaka Shin-ichi Ando Akiko Chishaki |
| author_sort | Hiroyuki Sawatari |
| collection | DOAJ |
| description | Background: Compared with typically developing control children (CC), children with Down syndrome (DS) frequently exhibit sleep-disordered breathing (SDB) and unusual sleep postures (USPs). No studies have directly compared SDB-related signs and symptoms, SDB-related parameters, and USPs between children with DS and CC. This study aimed to evaluate the prevalences of SDB and USPs in children with DS and CC. Methods: We analyzed SDB-related parameters measured via overnight pulse oximetry and questionnaires administered to parents on SDB-related signs and symptoms, including sleeping postures. Estimated SDB was defined as a 3% oxygen desaturation index (ODI) ≥5 dips/h. Results: Fifty-one children with DS (4–5 years: N = 12, 6–10 years: N = 23, 11–15 years: N = 16) and sixty-three CC (4–5 years: N = 18, 6–10 years: N = 27, 11–15 years: N = 18) were included. The prevalence of estimated SDB and observed USPs was higher in children with DS than in CC (p < 0.0001). Among children aged 11–15 years old, but not those aged 4–5 and 6–10 years old, frequency of arousal and apnea (p = 0.045 and p = 0.01, respectively) were higher in children with DS than in CC. Multivariate analyses showed that DS was associated with SDB-related signs and symptoms, estimated SDB, 3% ODI, average oxygen saturation (SpO2), and nadir SpO2, while USPs were associated only with higher values of SpO2 <90%. Conclusions: Estimated SDB tended to increase in children with DS but decreased in CC with growth. USPs were more frequent in children with DS than in CC, especially in older children. USPs might indicate severe hypoxemia due to SDB in DS. |
| first_indexed | 2024-12-12T17:23:51Z |
| format | Article |
| id | doaj.art-a14163333ffd457d9117c6b555f0347f |
| institution | Directory Open Access Journal |
| issn | 2590-1427 |
| language | English |
| last_indexed | 2024-12-12T17:23:51Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sleep Medicine: X |
| spelling | doaj.art-a14163333ffd457d9117c6b555f0347f2022-12-22T00:17:34ZengElsevierSleep Medicine: X2590-14272022-12-014100045Characteristics of sleep-disordered breathing in children with down syndrome - A comparison with typically developing childrenHiroyuki Sawatari0Anita Rahmawati1Nobuko Moriyama2Kanae Fujita3Tomoko Ohkusa4Tomoko Nao5Nobuko Hashiguchi6Mari Nishizaka7Shin-ichi Ando8Akiko Chishaki9Department of Perioperative and Critical Care Management, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanDepartment of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, IndonesiaDepartment of Health Sciences, Kyushu University Graduate School of Medical Sciences, Fukuoka, JapanDepartment of Health Sciences, Kyushu University Graduate School of Medical Sciences, Fukuoka, JapanFaculty of Health Sciences, Department of Nursing, Ube Frontier University, Yamaguchi, JapanFaculty of Health Sciences, Department of Nursing, Ube Frontier University, Yamaguchi, JapanDepartment of Health Sciences, Kyushu University Graduate School of Medical Sciences, Fukuoka, JapanKirameki Project Carrier Support Center, Kyushu University Hospital, Fukuoka, JapanSleep Apnea Center, Kyushu University Hospital, Fukuoka, JapanFukuoka Dental College Hospital and Fukuoka Nursing College, Graduate School of Nursing, Fukuoka, Japan; Corresponding author. Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka, 814-0139, Japan. Fax: +81 92 801 0459.Background: Compared with typically developing control children (CC), children with Down syndrome (DS) frequently exhibit sleep-disordered breathing (SDB) and unusual sleep postures (USPs). No studies have directly compared SDB-related signs and symptoms, SDB-related parameters, and USPs between children with DS and CC. This study aimed to evaluate the prevalences of SDB and USPs in children with DS and CC. Methods: We analyzed SDB-related parameters measured via overnight pulse oximetry and questionnaires administered to parents on SDB-related signs and symptoms, including sleeping postures. Estimated SDB was defined as a 3% oxygen desaturation index (ODI) ≥5 dips/h. Results: Fifty-one children with DS (4–5 years: N = 12, 6–10 years: N = 23, 11–15 years: N = 16) and sixty-three CC (4–5 years: N = 18, 6–10 years: N = 27, 11–15 years: N = 18) were included. The prevalence of estimated SDB and observed USPs was higher in children with DS than in CC (p < 0.0001). Among children aged 11–15 years old, but not those aged 4–5 and 6–10 years old, frequency of arousal and apnea (p = 0.045 and p = 0.01, respectively) were higher in children with DS than in CC. Multivariate analyses showed that DS was associated with SDB-related signs and symptoms, estimated SDB, 3% ODI, average oxygen saturation (SpO2), and nadir SpO2, while USPs were associated only with higher values of SpO2 <90%. Conclusions: Estimated SDB tended to increase in children with DS but decreased in CC with growth. USPs were more frequent in children with DS than in CC, especially in older children. USPs might indicate severe hypoxemia due to SDB in DS.http://www.sciencedirect.com/science/article/pii/S2590142722000040Down syndromeSleep-disordered breathingChildrenSleep postureParental reports |
| spellingShingle | Hiroyuki Sawatari Anita Rahmawati Nobuko Moriyama Kanae Fujita Tomoko Ohkusa Tomoko Nao Nobuko Hashiguchi Mari Nishizaka Shin-ichi Ando Akiko Chishaki Characteristics of sleep-disordered breathing in children with down syndrome - A comparison with typically developing children Sleep Medicine: X Down syndrome Sleep-disordered breathing Children Sleep posture Parental reports |
| title | Characteristics of sleep-disordered breathing in children with down syndrome - A comparison with typically developing children |
| title_full | Characteristics of sleep-disordered breathing in children with down syndrome - A comparison with typically developing children |
| title_fullStr | Characteristics of sleep-disordered breathing in children with down syndrome - A comparison with typically developing children |
| title_full_unstemmed | Characteristics of sleep-disordered breathing in children with down syndrome - A comparison with typically developing children |
| title_short | Characteristics of sleep-disordered breathing in children with down syndrome - A comparison with typically developing children |
| title_sort | characteristics of sleep disordered breathing in children with down syndrome a comparison with typically developing children |
| topic | Down syndrome Sleep-disordered breathing Children Sleep posture Parental reports |
| url | http://www.sciencedirect.com/science/article/pii/S2590142722000040 |
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