The Legacy of Parental Obesity: Mechanisms of Non-Genetic Transmission and Reversibility
While a dramatic increase in obesity and related comorbidities is being witnessed, the underlying mechanisms of their spread remain unresolved. Epigenetic and other non-genetic mechanisms tend to be prominent candidates involved in the establishment and transmission of obesity and associated metabol...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/10/2461 |
| _version_ | 1797475084889227264 |
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| author | Gemma Comas-Armangue Lela Makharadze Melisa Gomez-Velazquez Raffaele Teperino |
| author_facet | Gemma Comas-Armangue Lela Makharadze Melisa Gomez-Velazquez Raffaele Teperino |
| author_sort | Gemma Comas-Armangue |
| collection | DOAJ |
| description | While a dramatic increase in obesity and related comorbidities is being witnessed, the underlying mechanisms of their spread remain unresolved. Epigenetic and other non-genetic mechanisms tend to be prominent candidates involved in the establishment and transmission of obesity and associated metabolic disorders to offspring. Here, we review recent findings addressing those candidates, in the context of maternal and paternal influences, and discuss the effectiveness of preventive measures. |
| first_indexed | 2024-03-09T20:39:09Z |
| format | Article |
| id | doaj.art-a141e741372d4932bec206e77915e8ff |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:39:09Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-a141e741372d4932bec206e77915e8ff2023-11-23T23:03:25ZengMDPI AGBiomedicines2227-90592022-10-011010246110.3390/biomedicines10102461The Legacy of Parental Obesity: Mechanisms of Non-Genetic Transmission and ReversibilityGemma Comas-Armangue0Lela Makharadze1Melisa Gomez-Velazquez2Raffaele Teperino3German Research Center for Environmental Health Neuherberg, Institute of Experimental Genetics, Helmholtz Zentrum München, 85764 Neuherberg, GermanyGerman Research Center for Environmental Health Neuherberg, Institute of Experimental Genetics, Helmholtz Zentrum München, 85764 Neuherberg, GermanyGerman Research Center for Environmental Health Neuherberg, Institute of Experimental Genetics, Helmholtz Zentrum München, 85764 Neuherberg, GermanyGerman Research Center for Environmental Health Neuherberg, Institute of Experimental Genetics, Helmholtz Zentrum München, 85764 Neuherberg, GermanyWhile a dramatic increase in obesity and related comorbidities is being witnessed, the underlying mechanisms of their spread remain unresolved. Epigenetic and other non-genetic mechanisms tend to be prominent candidates involved in the establishment and transmission of obesity and associated metabolic disorders to offspring. Here, we review recent findings addressing those candidates, in the context of maternal and paternal influences, and discuss the effectiveness of preventive measures.https://www.mdpi.com/2227-9059/10/10/2461obesityHFDepigeneticsDOHaDPOHaDnon-genetic inheritance |
| spellingShingle | Gemma Comas-Armangue Lela Makharadze Melisa Gomez-Velazquez Raffaele Teperino The Legacy of Parental Obesity: Mechanisms of Non-Genetic Transmission and Reversibility Biomedicines obesity HFD epigenetics DOHaD POHaD non-genetic inheritance |
| title | The Legacy of Parental Obesity: Mechanisms of Non-Genetic Transmission and Reversibility |
| title_full | The Legacy of Parental Obesity: Mechanisms of Non-Genetic Transmission and Reversibility |
| title_fullStr | The Legacy of Parental Obesity: Mechanisms of Non-Genetic Transmission and Reversibility |
| title_full_unstemmed | The Legacy of Parental Obesity: Mechanisms of Non-Genetic Transmission and Reversibility |
| title_short | The Legacy of Parental Obesity: Mechanisms of Non-Genetic Transmission and Reversibility |
| title_sort | legacy of parental obesity mechanisms of non genetic transmission and reversibility |
| topic | obesity HFD epigenetics DOHaD POHaD non-genetic inheritance |
| url | https://www.mdpi.com/2227-9059/10/10/2461 |
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