Computed Tomography-Assisted Study of the Liquid Contrast Agent’s Spread in a Hydrogel Phantom of the Brain Tissue
Studying transport processes in the brain’s extracellular space is a complicated problem when considering the brain’s tissue. Tests of corresponding physical and mathematical problems, as well as the need for materials with cheap but realistic properties to allow for testing of drug delivery systems...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Fluids |
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| Online Access: | https://www.mdpi.com/2311-5521/8/6/167 |
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| author | Anastasia S. Vanina Alexander V. Sychev Anastasia I. Lavrova Pavel V. Gavrilov Polina L. Andropova Elena V. Grekhnyova Tatiana N. Kudryavtseva Eugene B. Postnikov |
| author_facet | Anastasia S. Vanina Alexander V. Sychev Anastasia I. Lavrova Pavel V. Gavrilov Polina L. Andropova Elena V. Grekhnyova Tatiana N. Kudryavtseva Eugene B. Postnikov |
| author_sort | Anastasia S. Vanina |
| collection | DOAJ |
| description | Studying transport processes in the brain’s extracellular space is a complicated problem when considering the brain’s tissue. Tests of corresponding physical and mathematical problems, as well as the need for materials with cheap but realistic properties to allow for testing of drug delivery systems, lead to the development of artificial phantom media, one kind of which is explored in this work. We report results from quantifying the spread of a standard contrast agent used in clinical computed tomography, Iopromide, in samples of collagen-based hydrogels. Its pure variant as well as samples supplied with lipid and surfactant additives were explored. By comparing to solutions of the diffusion equation which reproduce these data, the respective diffusion coefficients were determined. It was shown that they are relevant to the range typical for living tissue, grow with elevation in the lipid content and diminish with growth in surfactant concentration. |
| first_indexed | 2024-03-11T02:29:00Z |
| format | Article |
| id | doaj.art-a1435806565743a288308532417e7a18 |
| institution | Directory Open Access Journal |
| issn | 2311-5521 |
| language | English |
| last_indexed | 2024-03-11T02:29:00Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Fluids |
| spelling | doaj.art-a1435806565743a288308532417e7a182023-11-18T10:23:13ZengMDPI AGFluids2311-55212023-05-018616710.3390/fluids8060167Computed Tomography-Assisted Study of the Liquid Contrast Agent’s Spread in a Hydrogel Phantom of the Brain TissueAnastasia S. Vanina0Alexander V. Sychev1Anastasia I. Lavrova2Pavel V. Gavrilov3Polina L. Andropova4Elena V. Grekhnyova5Tatiana N. Kudryavtseva6Eugene B. Postnikov7Laboratory of Organic Synthesis, Kursk State University, Radishcheva St. 33, Kursk 305000, RussiaResearch Center for Condensed Matter Physics, Kursk State University, Radishcheva St. 33, Kursk 305000, RussiaSaint-Petersburg State Research Institute of Phthisiopulmonology, Lygovsky Av. 2–4, Saint-Petersburg 191036, RussiaSaint-Petersburg State Research Institute of Phthisiopulmonology, Lygovsky Av. 2–4, Saint-Petersburg 191036, RussiaN. P. Bechtereva Institute of the Human Brain, Russian Academy of Sciences, Akad. Pavlov St. 9, Saint-Petersburg 197376, RussiaLaboratory of Organic Synthesis, Kursk State University, Radishcheva St. 33, Kursk 305000, RussiaLaboratory of Organic Synthesis, Kursk State University, Radishcheva St. 33, Kursk 305000, RussiaDepartment of Theoretical Physics, Kursk State University, Radishcheva St. 33, Kursk 305000, RussiaStudying transport processes in the brain’s extracellular space is a complicated problem when considering the brain’s tissue. Tests of corresponding physical and mathematical problems, as well as the need for materials with cheap but realistic properties to allow for testing of drug delivery systems, lead to the development of artificial phantom media, one kind of which is explored in this work. We report results from quantifying the spread of a standard contrast agent used in clinical computed tomography, Iopromide, in samples of collagen-based hydrogels. Its pure variant as well as samples supplied with lipid and surfactant additives were explored. By comparing to solutions of the diffusion equation which reproduce these data, the respective diffusion coefficients were determined. It was shown that they are relevant to the range typical for living tissue, grow with elevation in the lipid content and diminish with growth in surfactant concentration.https://www.mdpi.com/2311-5521/8/6/167hydrogelbrain’s parenchyma phantomfluid flowdiffusioncomputed tomography |
| spellingShingle | Anastasia S. Vanina Alexander V. Sychev Anastasia I. Lavrova Pavel V. Gavrilov Polina L. Andropova Elena V. Grekhnyova Tatiana N. Kudryavtseva Eugene B. Postnikov Computed Tomography-Assisted Study of the Liquid Contrast Agent’s Spread in a Hydrogel Phantom of the Brain Tissue Fluids hydrogel brain’s parenchyma phantom fluid flow diffusion computed tomography |
| title | Computed Tomography-Assisted Study of the Liquid Contrast Agent’s Spread in a Hydrogel Phantom of the Brain Tissue |
| title_full | Computed Tomography-Assisted Study of the Liquid Contrast Agent’s Spread in a Hydrogel Phantom of the Brain Tissue |
| title_fullStr | Computed Tomography-Assisted Study of the Liquid Contrast Agent’s Spread in a Hydrogel Phantom of the Brain Tissue |
| title_full_unstemmed | Computed Tomography-Assisted Study of the Liquid Contrast Agent’s Spread in a Hydrogel Phantom of the Brain Tissue |
| title_short | Computed Tomography-Assisted Study of the Liquid Contrast Agent’s Spread in a Hydrogel Phantom of the Brain Tissue |
| title_sort | computed tomography assisted study of the liquid contrast agent s spread in a hydrogel phantom of the brain tissue |
| topic | hydrogel brain’s parenchyma phantom fluid flow diffusion computed tomography |
| url | https://www.mdpi.com/2311-5521/8/6/167 |
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