A meta-analysis of single base-pair substitutions in translational termination codons ('nonstop' mutations) that cause human inherited disease

A meta-analysis of single base-pair substitutions in translational termination codons ('nonstop' mutations) that cause human inherited disease

<p>Abstract</p> <p>'Nonstop' mutations are single base-pair substitutions that occur within translational termination (stop) codons and which can lead to the continued and inappropriate translation of the mRNA into the 3'-untranslated region. We have performed a meta...

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Bibliographic Details
Main Authors: Hamby Stephen E, Thomas Nick ST, Cooper David N, Chuzhanova Nadia
Format: Article
Language:English
Published: BMC 2011-05-01
Series:Human Genomics
Subjects:
human inherited disease
stop codon
3'-untranslated region
nonstop mutation
nonstop mRNA decay
Online Access:http://www.humgenomics.com/content/5/4/241

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