Collagen COL22A1 maintains vascular stability and mutations in COL22A1 are potentially associated with intracranial aneurysms

Collagen COL22A1 maintains vascular stability and mutations in COL22A1 are potentially associated with intracranial aneurysms

Collagen XXII (COL22A1) is a quantitatively minor collagen, which belongs to the family of fibril-associated collagens with interrupted triple helices. Its biological function has been poorly understood. Here, we used a genome-editing approach to generate a loss-of-function mutant in zebrafish col22...

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Bibliographic Details
Main Authors: Quynh V. Ton, Daniel Leino, Sarah A. Mowery, Nina O. Bredemeier, Pascal J. Lafontant, Allison Lubert, Suman Gurung, Janice L. Farlow, Tatiana M. Foroud, Joseph Broderick, Saulius Sumanas
Format: Article
Language:English
Published: The Company of Biologists 2018-12-01
Series:Disease Models & Mechanisms
Subjects:
Intracranial aneurysms
Collagen
Zebrafish
Vascular integrity
Online Access:http://dmm.biologists.org/content/11/12/dmm033654

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