FK506 and Lactobacillus acidophilus ameliorate acute graft-versus-host disease by modulating the T helper 17/regulatory T-cell balance

FK506 and Lactobacillus acidophilus ameliorate acute graft-versus-host disease by modulating the T helper 17/regulatory T-cell balance

Abstract Background Graft-versus-host disease (GvHD) is a critical complication after allogeneic hematopoietic stem cell transplantation (HSCT). The immunosuppressants given to patients undergoing allogeneic HSCT disturb the microbiome and the host immune system, potentially leading to dysbiosis and...

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Bibliographic Details
Main Authors: Jin-Ah Beak, Min-Jung Park, Se-Young Kim, JooYeon Jhun, Jin Seok Woo, Jeong Won Choi, Hyun Sik Na, Soon Kyu Lee, Jong Young Choi, Mi-La Cho
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Journal of Translational Medicine
Subjects:
L. acidophilus
FK506
Th17 cell
Regulatory T cell
Allogeneic response
GvHD
Online Access:https://doi.org/10.1186/s12967-022-03303-z

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