Somatic comorbidity and the progression of cognitive impairment
BackgroundThere are usually multiple factors underlying dementia in old age. Somatic comorbidity is one important element that influences the progression of cognitive impairment.ObjectiveThe goal of this study was to assess the relationship between the progression of cognitive impairment and the pre...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1219449/full |
| _version_ | 1797595175739981824 |
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| author | Leszek Bidzan Leszek Bidzan Paweł Jurek Michał Olech Monika Bidzan-Wiącek Ilona Bidzan-Bluma Ilona Bidzan-Bluma Mariola Bidzan Mariola Bidzan |
| author_facet | Leszek Bidzan Leszek Bidzan Paweł Jurek Michał Olech Monika Bidzan-Wiącek Ilona Bidzan-Bluma Ilona Bidzan-Bluma Mariola Bidzan Mariola Bidzan |
| author_sort | Leszek Bidzan |
| collection | DOAJ |
| description | BackgroundThere are usually multiple factors underlying dementia in old age. Somatic comorbidity is one important element that influences the progression of cognitive impairment.ObjectiveThe goal of this study was to assess the relationship between the progression of cognitive impairment and the presence and severity of comorbidities based on a four-year observation.MaterialOut of 128 patients from the Clinic for Outpatients in Gdansk, who were recruited into the study based on the criteria of the Working Group on Mild Cognitive Impairment, a total of 93 participants completed the four-year observation. Only the data from participants who completed the full period of observations were analysed. The mean age of the group was M = 75.93 (SD = 9.43). The level of progression of cognitive impairment was measured using the Clinical Dementia Rating Scale – Sum of Boxes, the severity of comorbidities was measured using the modified Cumulative Illness Rating Scale, and, additionally, at the time of inclusion in the study, participants were assessed using the MMSE scale and the Activity Scale, and sociodemographic data were collected. The Generalized Estimating Equations method was employed to fit a marginal model for analyzing the data collected in a repeated measures design. The tested model elucidated the role of the overall severity of comorbidities in explaining the progression of cognitive impairment, while controlling for everyday activity and basic demographic variables.ResultsDuring the four-year observation, a significant decline in cognitive function (B = 1.86, p < 0.01) was observed in the examined sample. The statistical analysis revealed that individuals with higher overall severity of comorbidities exhibited significantly more pronounced progression of cognitive impairment over time. Regarding particular comorbidities, metabolic diseases were found to be associated with a poorer prognosis (rho = 0.41, p < 0.05). Furthermore, a time physical activity interaction was identified as predicting cognitive impairment, indicating that individuals who were more physically active at the beginning of the study exhibited significantly less pronounced progression of cognitive impairment over the course of the 4 years.ConclusionThis study suggests the important roles of comorbidities and physical activity for the prognosis of mild cognitive impairment. |
| first_indexed | 2024-03-11T02:32:54Z |
| format | Article |
| id | doaj.art-a1486a9e6d6647a9bcea85f3e4db5023 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-11T02:32:54Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-a1486a9e6d6647a9bcea85f3e4db50232023-11-18T10:07:16ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-11-011510.3389/fnagi.2023.12194491219449Somatic comorbidity and the progression of cognitive impairmentLeszek Bidzan0Leszek Bidzan1Paweł Jurek2Michał Olech3Monika Bidzan-Wiącek4Ilona Bidzan-Bluma5Ilona Bidzan-Bluma6Mariola Bidzan7Mariola Bidzan8Faculty of Medicine, Medical University of Gdańsk, Gdańsk, PolandDepartment of Health Sciences, Pomeranian University in Słupsk, Słupsk, PolandInstitute of Psychology, University of Gdańsk, Gdańsk, PolandFaculty of Health Sciences, Medical University of Gdańsk, Gdańsk, PolandFaculty of Health Sciences, Medical University of Gdańsk, Gdańsk, PolandInstitute of Psychology, University of Gdańsk, Gdańsk, PolandInstitute of Pedagogy and Languages, University of Applied Sciences in Elbląg, Elbląg, PolandInstitute of Psychology, University of Gdańsk, Gdańsk, PolandInstitute of Pedagogy and Languages, University of Applied Sciences in Elbląg, Elbląg, PolandBackgroundThere are usually multiple factors underlying dementia in old age. Somatic comorbidity is one important element that influences the progression of cognitive impairment.ObjectiveThe goal of this study was to assess the relationship between the progression of cognitive impairment and the presence and severity of comorbidities based on a four-year observation.MaterialOut of 128 patients from the Clinic for Outpatients in Gdansk, who were recruited into the study based on the criteria of the Working Group on Mild Cognitive Impairment, a total of 93 participants completed the four-year observation. Only the data from participants who completed the full period of observations were analysed. The mean age of the group was M = 75.93 (SD = 9.43). The level of progression of cognitive impairment was measured using the Clinical Dementia Rating Scale – Sum of Boxes, the severity of comorbidities was measured using the modified Cumulative Illness Rating Scale, and, additionally, at the time of inclusion in the study, participants were assessed using the MMSE scale and the Activity Scale, and sociodemographic data were collected. The Generalized Estimating Equations method was employed to fit a marginal model for analyzing the data collected in a repeated measures design. The tested model elucidated the role of the overall severity of comorbidities in explaining the progression of cognitive impairment, while controlling for everyday activity and basic demographic variables.ResultsDuring the four-year observation, a significant decline in cognitive function (B = 1.86, p < 0.01) was observed in the examined sample. The statistical analysis revealed that individuals with higher overall severity of comorbidities exhibited significantly more pronounced progression of cognitive impairment over time. Regarding particular comorbidities, metabolic diseases were found to be associated with a poorer prognosis (rho = 0.41, p < 0.05). Furthermore, a time physical activity interaction was identified as predicting cognitive impairment, indicating that individuals who were more physically active at the beginning of the study exhibited significantly less pronounced progression of cognitive impairment over the course of the 4 years.ConclusionThis study suggests the important roles of comorbidities and physical activity for the prognosis of mild cognitive impairment.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1219449/fullcognitiondementiaMCIcomorbiditiesneurosciencesMMSE |
| spellingShingle | Leszek Bidzan Leszek Bidzan Paweł Jurek Michał Olech Monika Bidzan-Wiącek Ilona Bidzan-Bluma Ilona Bidzan-Bluma Mariola Bidzan Mariola Bidzan Somatic comorbidity and the progression of cognitive impairment Frontiers in Aging Neuroscience cognition dementia MCI comorbidities neurosciences MMSE |
| title | Somatic comorbidity and the progression of cognitive impairment |
| title_full | Somatic comorbidity and the progression of cognitive impairment |
| title_fullStr | Somatic comorbidity and the progression of cognitive impairment |
| title_full_unstemmed | Somatic comorbidity and the progression of cognitive impairment |
| title_short | Somatic comorbidity and the progression of cognitive impairment |
| title_sort | somatic comorbidity and the progression of cognitive impairment |
| topic | cognition dementia MCI comorbidities neurosciences MMSE |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1219449/full |
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