The association between area-level residential instability and gray matter volume changes
Introduction Area-level residential instability (ARI), an index of social fragmentation, has been shown to explain the association between urbanicity and psychosis. Urban upbringing has been shown to be associated with decreased gray matter volumes (GMV)s of brain regions corresponding to the right...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2022-06-01
|
| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822020338/type/journal_article |
| _version_ | 1797617149193224192 |
|---|---|
| author | B. Ku J. Addington C. Bearden K. Cadenhead T. Cannon M. Compton B. Cornblatt B. Druss M. Keshavan D. Mathalon T. Mcglashan D. Perkins L. Seidman W. Stone M. Tsuang S. Woods E. Walker |
| author_facet | B. Ku J. Addington C. Bearden K. Cadenhead T. Cannon M. Compton B. Cornblatt B. Druss M. Keshavan D. Mathalon T. Mcglashan D. Perkins L. Seidman W. Stone M. Tsuang S. Woods E. Walker |
| author_sort | B. Ku |
| collection | DOAJ |
| description |
Introduction
Area-level residential instability (ARI), an index of social fragmentation, has been shown to explain the association between urbanicity and psychosis. Urban upbringing has been shown to be associated with decreased gray matter volumes (GMV)s of brain regions corresponding to the right caudal middle frontal gyrus (CMFG) and rostral anterior cingulate cortex (rACC).
Objectives
We hypothesize that greater ARI will be associated with reduced right posterior CMFG and rACC GMVs.
Methods
Data were collected at baseline as part of the North American Prodrome Longitudinal Study. Counties where participants resided during childhood were geographically coded using the US Censuses to area-level factors. ARI was defined as the percentage of residents living in a different house five years ago. Generalized linear mixed models tested associations between ARI and GMVs.
Results
This study included 29 HC and 64 CHR-P individuals who were aged 12 to 24 years, had remained in their baseline residential area, and had magnetic resonance imaging scans. ARI was associated with reduced right CMFG (adjusted β = -0.258; 95% CI = -0.502 – -0.015) and right rACC volumes (adjusted β = -0.318; 95% CI = -0.612 – -0.023). The interaction terms (ARI X diagnostic group) in the prediction of both brain regions were not significant, indicating that the relationships between ARI and regional brain volumes held for both CHR-P and HCs.
Conclusions
Like urban upbringing, ARI may be an important social environmental characteristic that adversely impacts brain regions related to schizophrenia.
Disclosure
No significant relationships.
|
| first_indexed | 2024-03-11T07:51:43Z |
| format | Article |
| id | doaj.art-a14a0d3998c34308bc5df90b315983fd |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:51:43Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-a14a0d3998c34308bc5df90b315983fd2023-11-17T05:06:42ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S787S78710.1192/j.eurpsy.2022.2033The association between area-level residential instability and gray matter volume changesB. Ku0J. Addington1C. Bearden2K. Cadenhead3T. Cannon4M. Compton5B. Cornblatt6B. Druss7M. Keshavan8D. Mathalon9T. Mcglashan10D. Perkins11L. Seidman12W. Stone13M. Tsuang14S. Woods15E. Walker16Emory, Psychiatry And Behavioral Sciences, Atlanta, United States of AmericaUniversity of Calgary, Psychiatry, Calgary, CanadaUCLA, Psychiatry, Los Angeles, United States of AmericaUCSD, Psychiatry, San Diego, United States of AmericaYale, Psychiatry, New Haven, United States of AmericaColumbia, Psychiatry, New York, United States of AmericaZucker Hillside Hospital, Psychiatry, Long Island, United States of AmericaEmory, Department Of Health Policy And Management, Atlanta, United States of AmericaHarvard, Psychiatry, Boston, United States of AmericaUCSF, Psychiatry, San Francisco, United States of AmericaYale, Psychiatry, New Haven, United States of AmericaUniversity of North Carolina, Psychiatry, Chapel Hill, United States of AmericaHarvard, Psychiatry, Boston, United States of AmericaHarvard, Psychiatry, Boston, United States of AmericaUCSD, Psychiatry, San Diego, United States of AmericaYale, Psychiatry, New Haven, United States of AmericaEmory, Psychology, Atlanta, United States of America Introduction Area-level residential instability (ARI), an index of social fragmentation, has been shown to explain the association between urbanicity and psychosis. Urban upbringing has been shown to be associated with decreased gray matter volumes (GMV)s of brain regions corresponding to the right caudal middle frontal gyrus (CMFG) and rostral anterior cingulate cortex (rACC). Objectives We hypothesize that greater ARI will be associated with reduced right posterior CMFG and rACC GMVs. Methods Data were collected at baseline as part of the North American Prodrome Longitudinal Study. Counties where participants resided during childhood were geographically coded using the US Censuses to area-level factors. ARI was defined as the percentage of residents living in a different house five years ago. Generalized linear mixed models tested associations between ARI and GMVs. Results This study included 29 HC and 64 CHR-P individuals who were aged 12 to 24 years, had remained in their baseline residential area, and had magnetic resonance imaging scans. ARI was associated with reduced right CMFG (adjusted β = -0.258; 95% CI = -0.502 – -0.015) and right rACC volumes (adjusted β = -0.318; 95% CI = -0.612 – -0.023). The interaction terms (ARI X diagnostic group) in the prediction of both brain regions were not significant, indicating that the relationships between ARI and regional brain volumes held for both CHR-P and HCs. Conclusions Like urban upbringing, ARI may be an important social environmental characteristic that adversely impacts brain regions related to schizophrenia. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822020338/type/journal_articleclinical high risk for psychosisgrey matter volumeresidential instabilityarea-level factors |
| spellingShingle | B. Ku J. Addington C. Bearden K. Cadenhead T. Cannon M. Compton B. Cornblatt B. Druss M. Keshavan D. Mathalon T. Mcglashan D. Perkins L. Seidman W. Stone M. Tsuang S. Woods E. Walker The association between area-level residential instability and gray matter volume changes European Psychiatry clinical high risk for psychosis grey matter volume residential instability area-level factors |
| title | The association between area-level residential instability and gray matter volume changes |
| title_full | The association between area-level residential instability and gray matter volume changes |
| title_fullStr | The association between area-level residential instability and gray matter volume changes |
| title_full_unstemmed | The association between area-level residential instability and gray matter volume changes |
| title_short | The association between area-level residential instability and gray matter volume changes |
| title_sort | association between area level residential instability and gray matter volume changes |
| topic | clinical high risk for psychosis grey matter volume residential instability area-level factors |
| url | https://www.cambridge.org/core/product/identifier/S0924933822020338/type/journal_article |
| work_keys_str_mv | AT bku theassociationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT jaddington theassociationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT cbearden theassociationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT kcadenhead theassociationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT tcannon theassociationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT mcompton theassociationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT bcornblatt theassociationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT bdruss theassociationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT mkeshavan theassociationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT dmathalon theassociationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT tmcglashan theassociationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT dperkins theassociationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT lseidman theassociationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT wstone theassociationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT mtsuang theassociationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT swoods theassociationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT ewalker theassociationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT bku associationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT jaddington associationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT cbearden associationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT kcadenhead associationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT tcannon associationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT mcompton associationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT bcornblatt associationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT bdruss associationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT mkeshavan associationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT dmathalon associationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT tmcglashan associationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT dperkins associationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT lseidman associationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT wstone associationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT mtsuang associationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT swoods associationbetweenarealevelresidentialinstabilityandgraymattervolumechanges AT ewalker associationbetweenarealevelresidentialinstabilityandgraymattervolumechanges |