Ketamine Blocks Morphine-Induced Conditioned Place Preference and Anxiety-Like Behaviors in Mice

Ketamine Blocks Morphine-Induced Conditioned Place Preference and Anxiety-Like Behaviors in Mice

Patients suffering from opioid use disorder often relapse during periods of abstinence, which is posited to be caused by negative affective states that drive motivated behaviors. Here, we explored whether conditioning mice with morphine in a conditioned place preference (CPP) training paradigm evoke...

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Bibliographic Details
Main Authors: Greer McKendrick, Hannah Garrett, Holly E. Jones, Dillon S. McDevitt, Sonakshi Sharma, Yuval Silberman, Nicholas M. Graziane
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
negative affect
morphine
conditioned place preference
anxiety
opioid use disorder
ketamine
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2020.00075/full

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