Freezing of gait in Parkinson’s disease is associated with the microstructural and functional changes of globus pallidus internus
BackgroundFreezing of gait (FOG) is a common motor symptom in advanced Parkinson’s disease (PD). However, the pathophysiology mechanism of FOG is not fully understood. The purpose of this study was to investigate microstructural abnormalities in subcortical gray matter and alterations in functional...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.975068/full |
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| author | Wenyi Kou Xuemei Wang Yuanchu Zheng Jiajia Zhao Huihui Cai Huimin Chen Binbin Sui Tao Feng Tao Feng |
| author_facet | Wenyi Kou Xuemei Wang Yuanchu Zheng Jiajia Zhao Huihui Cai Huimin Chen Binbin Sui Tao Feng Tao Feng |
| author_sort | Wenyi Kou |
| collection | DOAJ |
| description | BackgroundFreezing of gait (FOG) is a common motor symptom in advanced Parkinson’s disease (PD). However, the pathophysiology mechanism of FOG is not fully understood. The purpose of this study was to investigate microstructural abnormalities in subcortical gray matter and alterations in functional connectivity of the nuclei with microstructural changes. In addition, the correlations between these microstructural and functional changes and the severity of FOG were measured.Materials and methodsTwenty-four patients with FOG (PD-FOG), 22 PD patients without FOG (PD-nFOG), and 27 healthy controls (HC) were recruited. FOG Questionnaire (FOGQ) and Gait and Falling Questionnaire (GFQ) were assessed, and Timed Up and Go (TUG) tests were performed in PD-FOG patients. All subjects underwent diffusion tensor imaging (DTI) and resting-state functional MRI scanning. The DTI measures, including fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD), were extracted and measured from basal ganglia, thalamus, and substantia nigra. The nuclei with microstructural alterations were selected as seed regions to perform the seed-based resting-state functional connectivity.ResultsThe MD and RD values of the right globus pallidus internus (GPi) were significantly higher in patients with PD-FOG compared with PD-nFOG patients and HC. In PD-FOG patients, the MD and RD values of the right GPi were significantly correlated with the time of the TUG test in both ON and OFF states. The MD values were also correlated with the GFQ scores in PD-FOG patients. Resting-state functional connectivity between the right GPi and left middle occipital gyri decreased significantly in PD-FOG patients compared to PD-nFOG patients, and was negatively correlated with GFQ scores as well as the time of ON state TUG in PD-FOG patients.ConclusionMicrostructural alterations in the right GPi and functional connectivity between the right GPi and visual cortex may be associated with the pathophysiological mechanisms of FOG in PD patients. |
| first_indexed | 2024-12-10T15:39:15Z |
| format | Article |
| id | doaj.art-a14b601b39294ff7b67ee929062a715c |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-10T15:39:15Z |
| publishDate | 2022-08-01 |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-a14b601b39294ff7b67ee929062a715c2022-12-22T01:43:09ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-08-011410.3389/fnagi.2022.975068975068Freezing of gait in Parkinson’s disease is associated with the microstructural and functional changes of globus pallidus internusWenyi Kou0Xuemei Wang1Yuanchu Zheng2Jiajia Zhao3Huihui Cai4Huimin Chen5Binbin Sui6Tao Feng7Tao Feng8Center for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaCenter for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaCenter for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaCenter for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaCenter for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaTiantan Neuroimaging Center for Excellence, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaCenter for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaBackgroundFreezing of gait (FOG) is a common motor symptom in advanced Parkinson’s disease (PD). However, the pathophysiology mechanism of FOG is not fully understood. The purpose of this study was to investigate microstructural abnormalities in subcortical gray matter and alterations in functional connectivity of the nuclei with microstructural changes. In addition, the correlations between these microstructural and functional changes and the severity of FOG were measured.Materials and methodsTwenty-four patients with FOG (PD-FOG), 22 PD patients without FOG (PD-nFOG), and 27 healthy controls (HC) were recruited. FOG Questionnaire (FOGQ) and Gait and Falling Questionnaire (GFQ) were assessed, and Timed Up and Go (TUG) tests were performed in PD-FOG patients. All subjects underwent diffusion tensor imaging (DTI) and resting-state functional MRI scanning. The DTI measures, including fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD), were extracted and measured from basal ganglia, thalamus, and substantia nigra. The nuclei with microstructural alterations were selected as seed regions to perform the seed-based resting-state functional connectivity.ResultsThe MD and RD values of the right globus pallidus internus (GPi) were significantly higher in patients with PD-FOG compared with PD-nFOG patients and HC. In PD-FOG patients, the MD and RD values of the right GPi were significantly correlated with the time of the TUG test in both ON and OFF states. The MD values were also correlated with the GFQ scores in PD-FOG patients. Resting-state functional connectivity between the right GPi and left middle occipital gyri decreased significantly in PD-FOG patients compared to PD-nFOG patients, and was negatively correlated with GFQ scores as well as the time of ON state TUG in PD-FOG patients.ConclusionMicrostructural alterations in the right GPi and functional connectivity between the right GPi and visual cortex may be associated with the pathophysiological mechanisms of FOG in PD patients.https://www.frontiersin.org/articles/10.3389/fnagi.2022.975068/fullParkinson’s diseasefreezing of gaitdiffusion tensor imagingresting-state fMRImicrostructureglobus pallidus internus |
| spellingShingle | Wenyi Kou Xuemei Wang Yuanchu Zheng Jiajia Zhao Huihui Cai Huimin Chen Binbin Sui Tao Feng Tao Feng Freezing of gait in Parkinson’s disease is associated with the microstructural and functional changes of globus pallidus internus Frontiers in Aging Neuroscience Parkinson’s disease freezing of gait diffusion tensor imaging resting-state fMRI microstructure globus pallidus internus |
| title | Freezing of gait in Parkinson’s disease is associated with the microstructural and functional changes of globus pallidus internus |
| title_full | Freezing of gait in Parkinson’s disease is associated with the microstructural and functional changes of globus pallidus internus |
| title_fullStr | Freezing of gait in Parkinson’s disease is associated with the microstructural and functional changes of globus pallidus internus |
| title_full_unstemmed | Freezing of gait in Parkinson’s disease is associated with the microstructural and functional changes of globus pallidus internus |
| title_short | Freezing of gait in Parkinson’s disease is associated with the microstructural and functional changes of globus pallidus internus |
| title_sort | freezing of gait in parkinson s disease is associated with the microstructural and functional changes of globus pallidus internus |
| topic | Parkinson’s disease freezing of gait diffusion tensor imaging resting-state fMRI microstructure globus pallidus internus |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.975068/full |
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