Effects of an Exercise Intervention on Gait Function in Young Survivors of Osteosarcoma with Megaendoprosthesis of the Lower Extremity—Results from the Pilot Randomized Controlled Trial proGAIT
Limb preservation with megaendoprosthesis in adolescents and young adults (AYA) with bone tumors is associated with functional limitations and gait abnormalities. The proGAIT trial evaluated the effectiveness of an exercise program on gait function and quality of life, functional scales (MSTS, TESS)...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/29/10/613 |
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| author | Simon Basteck Wiebke K. Guder Uta Dirksen Arno Krombholz Arne Streitbürger Dirk Reinhardt Miriam Götte |
| author_facet | Simon Basteck Wiebke K. Guder Uta Dirksen Arno Krombholz Arne Streitbürger Dirk Reinhardt Miriam Götte |
| author_sort | Simon Basteck |
| collection | DOAJ |
| description | Limb preservation with megaendoprosthesis in adolescents and young adults (AYA) with bone tumors is associated with functional limitations and gait abnormalities. The proGAIT trial evaluated the effectiveness of an exercise program on gait function and quality of life, functional scales (MSTS, TESS), functional mobility, and fatigue as secondary outcomes. Eleven AYA survivors of malignant osteosarcoma with a tumor endoprosthesis around the knee (mean age: 26.6 (±8.4) years) were randomized into an intervention group receiving an 8-week exercise program or into a control group. Gait function was assessed via 3D motion capture and analyzed using the Gait Profile Score (GPS) and the Gait Deviation Index (GDI). GDI and GPS scores of participants suggest deviations from a healthy reference group. The exercise intervention had small-to-medium positive effects on gait score GDI |d| = 0.50 (unaffected leg), |d| = 0.24 (affected leg), subjective functional scores TESS |d| = 0.74 and MSTS |d| = 0.49, and functional tests TUG and TUDS |d| = 0.61 and |d| = 0.52. None of these changes showed statistical significance. Promising intervention effects suggest that regular exercise could improve lower limb function and follow-up care for survivors; however, a powered RCT as a follow-up project needs to confirm the pilot findings. |
| first_indexed | 2024-03-09T20:24:28Z |
| format | Article |
| id | doaj.art-a14bc06b7d6d4d6fac2116cefddcefc3 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T20:24:28Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-a14bc06b7d6d4d6fac2116cefddcefc32023-11-23T23:41:02ZengMDPI AGCurrent Oncology1198-00521718-77292022-10-0129107754776710.3390/curroncol29100613Effects of an Exercise Intervention on Gait Function in Young Survivors of Osteosarcoma with Megaendoprosthesis of the Lower Extremity—Results from the Pilot Randomized Controlled Trial proGAITSimon Basteck0Wiebke K. Guder1Uta Dirksen2Arno Krombholz3Arne Streitbürger4Dirk Reinhardt5Miriam Götte6Department of Pediatric Hematology/Oncology, Clinic for Pediatrics III, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyDepartment of Orthopedic Oncology, West German Cancer Center, University Hospital Essen, 45147 Essen, GermanyDepartment of Pediatric Hematology/Oncology, Clinic for Pediatrics III, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyFaculty of Sport Science, Ruhr University Bochum, 44801 Bochum, GermanyDepartment of Orthopedic Oncology, West German Cancer Center, University Hospital Essen, 45147 Essen, GermanyDepartment of Pediatric Hematology/Oncology, Clinic for Pediatrics III, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyDepartment of Pediatric Hematology/Oncology, Clinic for Pediatrics III, West German Cancer Centre, University Hospital Essen, 45147 Essen, GermanyLimb preservation with megaendoprosthesis in adolescents and young adults (AYA) with bone tumors is associated with functional limitations and gait abnormalities. The proGAIT trial evaluated the effectiveness of an exercise program on gait function and quality of life, functional scales (MSTS, TESS), functional mobility, and fatigue as secondary outcomes. Eleven AYA survivors of malignant osteosarcoma with a tumor endoprosthesis around the knee (mean age: 26.6 (±8.4) years) were randomized into an intervention group receiving an 8-week exercise program or into a control group. Gait function was assessed via 3D motion capture and analyzed using the Gait Profile Score (GPS) and the Gait Deviation Index (GDI). GDI and GPS scores of participants suggest deviations from a healthy reference group. The exercise intervention had small-to-medium positive effects on gait score GDI |d| = 0.50 (unaffected leg), |d| = 0.24 (affected leg), subjective functional scores TESS |d| = 0.74 and MSTS |d| = 0.49, and functional tests TUG and TUDS |d| = 0.61 and |d| = 0.52. None of these changes showed statistical significance. Promising intervention effects suggest that regular exercise could improve lower limb function and follow-up care for survivors; however, a powered RCT as a follow-up project needs to confirm the pilot findings.https://www.mdpi.com/1718-7729/29/10/613bone tumorAYAendoprosthesisexercisegait analysislower limb function |
| spellingShingle | Simon Basteck Wiebke K. Guder Uta Dirksen Arno Krombholz Arne Streitbürger Dirk Reinhardt Miriam Götte Effects of an Exercise Intervention on Gait Function in Young Survivors of Osteosarcoma with Megaendoprosthesis of the Lower Extremity—Results from the Pilot Randomized Controlled Trial proGAIT Current Oncology bone tumor AYA endoprosthesis exercise gait analysis lower limb function |
| title | Effects of an Exercise Intervention on Gait Function in Young Survivors of Osteosarcoma with Megaendoprosthesis of the Lower Extremity—Results from the Pilot Randomized Controlled Trial proGAIT |
| title_full | Effects of an Exercise Intervention on Gait Function in Young Survivors of Osteosarcoma with Megaendoprosthesis of the Lower Extremity—Results from the Pilot Randomized Controlled Trial proGAIT |
| title_fullStr | Effects of an Exercise Intervention on Gait Function in Young Survivors of Osteosarcoma with Megaendoprosthesis of the Lower Extremity—Results from the Pilot Randomized Controlled Trial proGAIT |
| title_full_unstemmed | Effects of an Exercise Intervention on Gait Function in Young Survivors of Osteosarcoma with Megaendoprosthesis of the Lower Extremity—Results from the Pilot Randomized Controlled Trial proGAIT |
| title_short | Effects of an Exercise Intervention on Gait Function in Young Survivors of Osteosarcoma with Megaendoprosthesis of the Lower Extremity—Results from the Pilot Randomized Controlled Trial proGAIT |
| title_sort | effects of an exercise intervention on gait function in young survivors of osteosarcoma with megaendoprosthesis of the lower extremity results from the pilot randomized controlled trial progait |
| topic | bone tumor AYA endoprosthesis exercise gait analysis lower limb function |
| url | https://www.mdpi.com/1718-7729/29/10/613 |
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