Flecainide How and When: A Practical Guide in Supraventricular Arrhythmias
Transcatheter ablation was increasingly and successfully used to treat symptomatic drug refractory patients affected by supraventricular arrhythmias. Antiarrhythmic drug treatment still plays a major role in patient management, alone or combined with non-pharmacological therapies. Flecainide is an I...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/7/1456 |
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| author | Carlo Lavalle Michele Magnocavallo Martina Straito Luca Santini Giovanni Battista Forleo Massimo Grimaldi Roberto Badagliacca Luigi Lanata Renato Pietro Ricci |
| author_facet | Carlo Lavalle Michele Magnocavallo Martina Straito Luca Santini Giovanni Battista Forleo Massimo Grimaldi Roberto Badagliacca Luigi Lanata Renato Pietro Ricci |
| author_sort | Carlo Lavalle |
| collection | DOAJ |
| description | Transcatheter ablation was increasingly and successfully used to treat symptomatic drug refractory patients affected by supraventricular arrhythmias. Antiarrhythmic drug treatment still plays a major role in patient management, alone or combined with non-pharmacological therapies. Flecainide is an IC antiarrhythmic drug approved in 1984 from the Food and Drug Administration for the suppression of sustained ventricular tachycardia and later for acute cardioversion of atrial fibrillation and for sinus rhythm maintenance. Currently, flecainide is mostly used for sinus rhythm maintenance in atrial fibrillation (AF) patients without structural cardiomyopathy although recent studies enrolling different patient populations have demonstrated a good effectiveness and safety profile. How should we interpret the results of the CAST after the latest evidence? Is it possible to expand the indications of flecainide, and therefore, its use? This review aims to highlight the main characteristics of flecainide, as well as its optimal clinical use, delineating drug indications and contraindications and appropriate monitoring, based on the most recent evidence. |
| first_indexed | 2024-03-10T12:40:48Z |
| format | Article |
| id | doaj.art-a14c59d43edd4a3190fe0a4c3b7075a9 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T12:40:48Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a14c59d43edd4a3190fe0a4c3b7075a92023-11-21T13:55:35ZengMDPI AGJournal of Clinical Medicine2077-03832021-04-01107145610.3390/jcm10071456Flecainide How and When: A Practical Guide in Supraventricular ArrhythmiasCarlo Lavalle0Michele Magnocavallo1Martina Straito2Luca Santini3Giovanni Battista Forleo4Massimo Grimaldi5Roberto Badagliacca6Luigi Lanata7Renato Pietro Ricci8Department of Cardiovascular, Respiratory, Nephrological, Anesthesiological and Geriatric Sciences, “Sapienza” University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Cardiovascular, Respiratory, Nephrological, Anesthesiological and Geriatric Sciences, “Sapienza” University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Cardiovascular, Respiratory, Nephrological, Anesthesiological and Geriatric Sciences, “Sapienza” University of Rome, Policlinico Umberto I, 00161 Rome, ItalyDepartment of Cardiology, Ospedale GB Grassi, 00121 Ostia, ItalyDepartment of Cardiology, Azienda Ospedaliera-Universitaria “Luigi Sacco”, 20057 Milan, ItalyDepartment of Cardiology, Ospedale Generale Regionale F. Miulli, Acquaviva delle Fonti, 70021 Bari, ItalyDepartment of Cardiovascular, Respiratory, Nephrological, Anesthesiological and Geriatric Sciences, “Sapienza” University of Rome, Policlinico Umberto I, 00161 Rome, ItalyMedical Affairs Department, Dompé Farmaceutici SpA, 20057 Milan, ItalyCardioArrhythmology Center, 00161 Rome, ItalyTranscatheter ablation was increasingly and successfully used to treat symptomatic drug refractory patients affected by supraventricular arrhythmias. Antiarrhythmic drug treatment still plays a major role in patient management, alone or combined with non-pharmacological therapies. Flecainide is an IC antiarrhythmic drug approved in 1984 from the Food and Drug Administration for the suppression of sustained ventricular tachycardia and later for acute cardioversion of atrial fibrillation and for sinus rhythm maintenance. Currently, flecainide is mostly used for sinus rhythm maintenance in atrial fibrillation (AF) patients without structural cardiomyopathy although recent studies enrolling different patient populations have demonstrated a good effectiveness and safety profile. How should we interpret the results of the CAST after the latest evidence? Is it possible to expand the indications of flecainide, and therefore, its use? This review aims to highlight the main characteristics of flecainide, as well as its optimal clinical use, delineating drug indications and contraindications and appropriate monitoring, based on the most recent evidence.https://www.mdpi.com/2077-0383/10/7/1456flecainideflecainide controlled-releaseatrial fibrillationCASTsupraventricular arrhythmias |
| spellingShingle | Carlo Lavalle Michele Magnocavallo Martina Straito Luca Santini Giovanni Battista Forleo Massimo Grimaldi Roberto Badagliacca Luigi Lanata Renato Pietro Ricci Flecainide How and When: A Practical Guide in Supraventricular Arrhythmias Journal of Clinical Medicine flecainide flecainide controlled-release atrial fibrillation CAST supraventricular arrhythmias |
| title | Flecainide How and When: A Practical Guide in Supraventricular Arrhythmias |
| title_full | Flecainide How and When: A Practical Guide in Supraventricular Arrhythmias |
| title_fullStr | Flecainide How and When: A Practical Guide in Supraventricular Arrhythmias |
| title_full_unstemmed | Flecainide How and When: A Practical Guide in Supraventricular Arrhythmias |
| title_short | Flecainide How and When: A Practical Guide in Supraventricular Arrhythmias |
| title_sort | flecainide how and when a practical guide in supraventricular arrhythmias |
| topic | flecainide flecainide controlled-release atrial fibrillation CAST supraventricular arrhythmias |
| url | https://www.mdpi.com/2077-0383/10/7/1456 |
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