Brazilian workshop model to train investigators in chronic graft-versus-host disease clinical trials according to the 2005-2006 National Institutes of Health recommendations
BACKGROUND: The lack of standardization of clinical diagnostic criteria, classification and severity scores of chronic graft-versus-host disease led the National Institutes of Health to propose consensus criteria for the purpose of clinical trials. METHODS: Here we describe a one-day workshop model...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2011-10-01
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| Series: | Revista Brasileira de Hematologia e Hemoterapia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000500012 |
| _version_ | 1811297968515448832 |
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| author | Rita de Cássia Barbosa da Silva Tavares Márcia de Matos Silva Luis Fernando da Silva Bouzas Maria Cláudia Rodrigues Afonso Celso Vigorito Vaneusa Funke Marcos Mauad Maria Elvira Pizzigatti Correa Clarissa Vasconcellos de Souza Elenaide Nunes Alessandra Ferrari Ariana Paixão Talita Martins Érika Pallottino Mary Evelyn Dantas Flowers |
| author_facet | Rita de Cássia Barbosa da Silva Tavares Márcia de Matos Silva Luis Fernando da Silva Bouzas Maria Cláudia Rodrigues Afonso Celso Vigorito Vaneusa Funke Marcos Mauad Maria Elvira Pizzigatti Correa Clarissa Vasconcellos de Souza Elenaide Nunes Alessandra Ferrari Ariana Paixão Talita Martins Érika Pallottino Mary Evelyn Dantas Flowers |
| author_sort | Rita de Cássia Barbosa da Silva Tavares |
| collection | DOAJ |
| description | BACKGROUND: The lack of standardization of clinical diagnostic criteria, classification and severity scores of chronic graft-versus-host disease led the National Institutes of Health to propose consensus criteria for the purpose of clinical trials. METHODS: Here we describe a one-day workshop model conducted by the Chronic Graft-versus-Host Disease Brazil-Seattle Consortium Study Group to train investigators interested in participating in multicenter clinical trials in Brazil. Workshop participants included eight transplant physicians, one dermatologist, two dentists, three physical therapists and one psychologist from five institutions. Workshop participants evaluated nine patients with varying degrees of severity of mucocutaneous lesions and other manifestations of the disease followed by a training session to review and discuss the issues encountered with the evaluation and scoring of patients and in the methods used to evaluate grip strength and the 2-minute walk test. RESULTS: Most participants had difficulties in rating the percentage of each type of mucocutaneous lesion and thought 20 minutes was insufficient to evaluate and record the scores of each patient using the National Institutes of Health criteria and other cutaneous assessments. Several specific areas of difficulties encountered by the evaluators were: 1) determining the percentage of erythema in movable and non-movable sclerosis, 2) whether to score all cutaneous findings in a particular area or just the dominant lesion; 3) clarification of the definition of poikiloderma in chronic graft-versus-host disease; 4) discrepant interpretation of the mouth score and 5) clarification on the methodology used for the evaluation of grip strength and the 2-minute walk tests. CONCLUSIONS: Results of this workshop support the need to train investigators participating in clinical trials on chronic graft-versus-host disease. |
| first_indexed | 2024-04-13T06:12:56Z |
| format | Article |
| id | doaj.art-a14c5b6243964c6789e4d13616374448 |
| institution | Directory Open Access Journal |
| issn | 1516-8484 1806-0870 |
| language | English |
| last_indexed | 2024-04-13T06:12:56Z |
| publishDate | 2011-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista Brasileira de Hematologia e Hemoterapia |
| spelling | doaj.art-a14c5b6243964c6789e4d136163744482022-12-22T02:58:59ZengElsevierRevista Brasileira de Hematologia e Hemoterapia1516-84841806-08702011-10-0133535836610.5581/1516-8484.20110099Brazilian workshop model to train investigators in chronic graft-versus-host disease clinical trials according to the 2005-2006 National Institutes of Health recommendationsRita de Cássia Barbosa da Silva TavaresMárcia de Matos SilvaLuis Fernando da Silva BouzasMaria Cláudia RodriguesAfonso Celso VigoritoVaneusa FunkeMarcos MauadMaria Elvira Pizzigatti CorreaClarissa Vasconcellos de SouzaElenaide NunesAlessandra FerrariAriana PaixãoTalita MartinsÉrika PallottinoMary Evelyn Dantas FlowersBACKGROUND: The lack of standardization of clinical diagnostic criteria, classification and severity scores of chronic graft-versus-host disease led the National Institutes of Health to propose consensus criteria for the purpose of clinical trials. METHODS: Here we describe a one-day workshop model conducted by the Chronic Graft-versus-Host Disease Brazil-Seattle Consortium Study Group to train investigators interested in participating in multicenter clinical trials in Brazil. Workshop participants included eight transplant physicians, one dermatologist, two dentists, three physical therapists and one psychologist from five institutions. Workshop participants evaluated nine patients with varying degrees of severity of mucocutaneous lesions and other manifestations of the disease followed by a training session to review and discuss the issues encountered with the evaluation and scoring of patients and in the methods used to evaluate grip strength and the 2-minute walk test. RESULTS: Most participants had difficulties in rating the percentage of each type of mucocutaneous lesion and thought 20 minutes was insufficient to evaluate and record the scores of each patient using the National Institutes of Health criteria and other cutaneous assessments. Several specific areas of difficulties encountered by the evaluators were: 1) determining the percentage of erythema in movable and non-movable sclerosis, 2) whether to score all cutaneous findings in a particular area or just the dominant lesion; 3) clarification of the definition of poikiloderma in chronic graft-versus-host disease; 4) discrepant interpretation of the mouth score and 5) clarification on the methodology used for the evaluation of grip strength and the 2-minute walk tests. CONCLUSIONS: Results of this workshop support the need to train investigators participating in clinical trials on chronic graft-versus-host disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000500012Graft vs. host diseaseGraft vs. host diseaseHematopoietic stem cell transplantationTraining |
| spellingShingle | Rita de Cássia Barbosa da Silva Tavares Márcia de Matos Silva Luis Fernando da Silva Bouzas Maria Cláudia Rodrigues Afonso Celso Vigorito Vaneusa Funke Marcos Mauad Maria Elvira Pizzigatti Correa Clarissa Vasconcellos de Souza Elenaide Nunes Alessandra Ferrari Ariana Paixão Talita Martins Érika Pallottino Mary Evelyn Dantas Flowers Brazilian workshop model to train investigators in chronic graft-versus-host disease clinical trials according to the 2005-2006 National Institutes of Health recommendations Revista Brasileira de Hematologia e Hemoterapia Graft vs. host disease Graft vs. host disease Hematopoietic stem cell transplantation Training |
| title | Brazilian workshop model to train investigators in chronic graft-versus-host disease clinical trials according to the 2005-2006 National Institutes of Health recommendations |
| title_full | Brazilian workshop model to train investigators in chronic graft-versus-host disease clinical trials according to the 2005-2006 National Institutes of Health recommendations |
| title_fullStr | Brazilian workshop model to train investigators in chronic graft-versus-host disease clinical trials according to the 2005-2006 National Institutes of Health recommendations |
| title_full_unstemmed | Brazilian workshop model to train investigators in chronic graft-versus-host disease clinical trials according to the 2005-2006 National Institutes of Health recommendations |
| title_short | Brazilian workshop model to train investigators in chronic graft-versus-host disease clinical trials according to the 2005-2006 National Institutes of Health recommendations |
| title_sort | brazilian workshop model to train investigators in chronic graft versus host disease clinical trials according to the 2005 2006 national institutes of health recommendations |
| topic | Graft vs. host disease Graft vs. host disease Hematopoietic stem cell transplantation Training |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000500012 |
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