MR-Guided Radiotherapy: The Perfect Partner for Immunotherapy?
During the last years, preclinical and clinical studies have emerged supporting the rationale to integrate radiotherapy and immunotherapy. Radiotherapy may enhance the effects of immunotherapy by improving tumor antigen release, antigen presentation, and T-cell infiltration. Recently, magnetic reson...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.615697/full |
| _version_ | 1830191396940677120 |
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| author | Juliane Hörner-Rieber Juliane Hörner-Rieber Juliane Hörner-Rieber Juliane Hörner-Rieber Sebastian Klüter Sebastian Klüter Sebastian Klüter Jürgen Debus Jürgen Debus Jürgen Debus Jürgen Debus Jürgen Debus Jürgen Debus Gosse Adema Marleen Ansems Marcel Verheij |
| author_facet | Juliane Hörner-Rieber Juliane Hörner-Rieber Juliane Hörner-Rieber Juliane Hörner-Rieber Sebastian Klüter Sebastian Klüter Sebastian Klüter Jürgen Debus Jürgen Debus Jürgen Debus Jürgen Debus Jürgen Debus Jürgen Debus Gosse Adema Marleen Ansems Marcel Verheij |
| author_sort | Juliane Hörner-Rieber |
| collection | DOAJ |
| description | During the last years, preclinical and clinical studies have emerged supporting the rationale to integrate radiotherapy and immunotherapy. Radiotherapy may enhance the effects of immunotherapy by improving tumor antigen release, antigen presentation, and T-cell infiltration. Recently, magnetic resonance guided radiotherapy (MRgRT) has become clinically available. Compared to conventional radiotherapy techniques, MRgRT firstly allows for daily on-table treatment adaptation, which enables both dose escalation for increasing tumor response and superior sparing of radiosensitive organs-at-risk for reducing toxicity. The current review focuses on the potential of combining MR-guided adaptive radiotherapy with immunotherapy by providing an overview on the current status of MRgRT, latest developments in preclinical and clinical radio-immunotherapy, and the unique opportunities and challenges for MR-guided radio-immunotherapy. MRgRT might especially assist in answering open questions in radio-immunotherapy regarding optimal radiation dose, fractionation, timing of immunotherapy, appropriate irradiation volumes, and response prediction. |
| first_indexed | 2024-12-17T23:37:21Z |
| format | Article |
| id | doaj.art-a14db01ee0034d19a02d59b2511ca00a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-17T23:37:21Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a14db01ee0034d19a02d59b2511ca00a2022-12-21T21:28:31ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-02-011010.3389/fonc.2020.615697615697MR-Guided Radiotherapy: The Perfect Partner for Immunotherapy?Juliane Hörner-Rieber0Juliane Hörner-Rieber1Juliane Hörner-Rieber2Juliane Hörner-Rieber3Sebastian Klüter4Sebastian Klüter5Sebastian Klüter6Jürgen Debus7Jürgen Debus8Jürgen Debus9Jürgen Debus10Jürgen Debus11Jürgen Debus12Gosse Adema13Marleen Ansems14Marcel Verheij15Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, GermanyHeidelberg Institute of Radiation Oncology (HIRO), Heidelberg, GermanyNational Center for Tumor Diseases (NCT), Heidelberg, GermanyClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, GermanyHeidelberg Institute of Radiation Oncology (HIRO), Heidelberg, GermanyNational Center for Tumor Diseases (NCT), Heidelberg, GermanyDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, GermanyHeidelberg Institute of Radiation Oncology (HIRO), Heidelberg, GermanyNational Center for Tumor Diseases (NCT), Heidelberg, GermanyClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, GermanyHeidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, GermanyGerman Cancer Consortium (DKTK), Heidelberg, GermanyRadiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, NetherlandsRadiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, NetherlandsDepartment of Radiation Oncology, Radboud University Medical Center, Nijmegen, NetherlandsDuring the last years, preclinical and clinical studies have emerged supporting the rationale to integrate radiotherapy and immunotherapy. Radiotherapy may enhance the effects of immunotherapy by improving tumor antigen release, antigen presentation, and T-cell infiltration. Recently, magnetic resonance guided radiotherapy (MRgRT) has become clinically available. Compared to conventional radiotherapy techniques, MRgRT firstly allows for daily on-table treatment adaptation, which enables both dose escalation for increasing tumor response and superior sparing of radiosensitive organs-at-risk for reducing toxicity. The current review focuses on the potential of combining MR-guided adaptive radiotherapy with immunotherapy by providing an overview on the current status of MRgRT, latest developments in preclinical and clinical radio-immunotherapy, and the unique opportunities and challenges for MR-guided radio-immunotherapy. MRgRT might especially assist in answering open questions in radio-immunotherapy regarding optimal radiation dose, fractionation, timing of immunotherapy, appropriate irradiation volumes, and response prediction.https://www.frontiersin.org/articles/10.3389/fonc.2020.615697/fullmagnetic resonance-guided radiotherapyadaptive treatmentimmunotherapyradio-immunotherapypreclinical |
| spellingShingle | Juliane Hörner-Rieber Juliane Hörner-Rieber Juliane Hörner-Rieber Juliane Hörner-Rieber Sebastian Klüter Sebastian Klüter Sebastian Klüter Jürgen Debus Jürgen Debus Jürgen Debus Jürgen Debus Jürgen Debus Jürgen Debus Gosse Adema Marleen Ansems Marcel Verheij MR-Guided Radiotherapy: The Perfect Partner for Immunotherapy? Frontiers in Oncology magnetic resonance-guided radiotherapy adaptive treatment immunotherapy radio-immunotherapy preclinical |
| title | MR-Guided Radiotherapy: The Perfect Partner for Immunotherapy? |
| title_full | MR-Guided Radiotherapy: The Perfect Partner for Immunotherapy? |
| title_fullStr | MR-Guided Radiotherapy: The Perfect Partner for Immunotherapy? |
| title_full_unstemmed | MR-Guided Radiotherapy: The Perfect Partner for Immunotherapy? |
| title_short | MR-Guided Radiotherapy: The Perfect Partner for Immunotherapy? |
| title_sort | mr guided radiotherapy the perfect partner for immunotherapy |
| topic | magnetic resonance-guided radiotherapy adaptive treatment immunotherapy radio-immunotherapy preclinical |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.615697/full |
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