Fundamental Role of Pentose Phosphate Pathway within the Endoplasmic Reticulum in Glutamine Addiction of Triple-Negative Breast Cancer Cells

Fundamental Role of Pentose Phosphate Pathway within the Endoplasmic Reticulum in Glutamine Addiction of Triple-Negative Breast Cancer Cells

Cancer utilization of large glutamine equivalents contributes to diverging glucose-6-P flux toward the pentose phosphate shunt (PPP) to feed the building blocks and the antioxidant responses of rapidly proliferating cells. In addition to the well-acknowledged cytosolic pathway, cancer cells also run...

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Bibliographic Details
Main Authors: Cecilia Marini, Vanessa Cossu, Sonia Carta, Elisa Greotti, Daniela Gaglio, Nadia Bertola, Sabrina Chiesa, Silvia Bruno, Francesca Vitale, Marcella Bonanomi, Danilo Porro, Mattia Riondato, Anna Maria Orengo, Matteo Bauckneht, Silvia Morbelli, Silvia Ravera, Gianmario Sambuceti
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Antioxidants
Subjects:
glutamine metabolism
breast cancer
pentose phosphate pathway
redox balance
hexose-6-phosphate-dehydrogenase
<sup>18</sup>F-fluoro-deoxy-glucose
Online Access:https://www.mdpi.com/2076-3921/12/1/43

Internet

https://www.mdpi.com/2076-3921/12/1/43

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