A Space‐Time Conversion Vehicle for Programmed Multi‐Drugs Delivery into Pancreatic Tumor to Overcome Matrix and Reflux Barriers

A Space‐Time Conversion Vehicle for Programmed Multi‐Drugs Delivery into Pancreatic Tumor to Overcome Matrix and Reflux Barriers

Abstract The numerous biological barriers, which limit pharmacotherapy of pancreatic carcinoma, including inadequate drug accumulation in the tumor environment, a dense extracellular matrix (ECM) and efficient drug‐efflux mechanisms, illustrate the requirement of multifunctional delivery systems to...

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Bibliographic Details
Main Authors: Taotao Huo, Xiaoyi Zhang, Min Qian, Huifang Nie, Dong Liang, Chenteng Lin, Yafeng Yang, Wei Guo, Ulrich Lächelt, Rongqin Huang
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Advanced Science
Subjects:
covalent organic framework
multi‐drugs delivery
pancreatic carcinoma
programmed drug delivery
Online Access:https://doi.org/10.1002/advs.202200608

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