Association between tuberculosis, diabetes and 25 hydroxyvitamin D in Tanzania: a longitudinal case control study
Abstract Background Vitamin D level is inversely associated with tuberculosis (TB) and diabetes (DM). Vitamin D could be a mediator in the association between TB and DM. We examined the associations between vitamin D, TB and DM. Methods Consecutive adults with TB and sex- and age-matched volunteers...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2016-11-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-016-1960-x |
| _version_ | 1818580348060041216 |
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| author | Noémie Boillat-Blanco Pascal Bovet Kaushik L. Ramaiya Maliwasa Mganga Lilian T. Minja Lanja Saleh Medea Imboden Christian Schindler Sebastien Gagneux Claudia Daubenberger Klaus Reither Nicole Probst-Hensch |
| author_facet | Noémie Boillat-Blanco Pascal Bovet Kaushik L. Ramaiya Maliwasa Mganga Lilian T. Minja Lanja Saleh Medea Imboden Christian Schindler Sebastien Gagneux Claudia Daubenberger Klaus Reither Nicole Probst-Hensch |
| author_sort | Noémie Boillat-Blanco |
| collection | DOAJ |
| description | Abstract Background Vitamin D level is inversely associated with tuberculosis (TB) and diabetes (DM). Vitamin D could be a mediator in the association between TB and DM. We examined the associations between vitamin D, TB and DM. Methods Consecutive adults with TB and sex- and age-matched volunteers were included in a case-control study in Dar es Salaam, Tanzania. Glycemia and total vitamin D (25(OH)D) were measured at enrolment and after TB treatment in cases. The association between low 25(OH)D (<75 nmol/l) and TB was evaluated by logistic regression adjusted for age, sex, body mass index, socioeconomic status, sunshine hours, HIV and an interaction between low 25(OH)D and hyperglycemia. Results The prevalence of low 25(OH)D was similar in TB patients and controls (25.8 % versus 31.0 %; p = 0.22). In the subgroup of patients with persistent hyperglycemia (i.e. likely true diabetic patients), the proportion of patients with low 25(OH)D tended to be greater in TB patients (50 % versus 29.7 %; p = 0.20). The effect modification by persistent hyperglycemia persisted in the multivariate analysis (pinteraction = 0.01). Conclusions Low 25(OH)D may increase TB risk in patients with underlying DM. Trials should examine if this association is causal and whether adjunct vitamin D therapy is beneficial in this population. |
| first_indexed | 2024-12-16T07:16:10Z |
| format | Article |
| id | doaj.art-a14e50993803428c94482cc9e2967837 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-16T07:16:10Z |
| publishDate | 2016-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-a14e50993803428c94482cc9e29678372022-12-21T22:39:46ZengBMCBMC Infectious Diseases1471-23342016-11-011611910.1186/s12879-016-1960-xAssociation between tuberculosis, diabetes and 25 hydroxyvitamin D in Tanzania: a longitudinal case control studyNoémie Boillat-Blanco0Pascal Bovet1Kaushik L. Ramaiya2Maliwasa Mganga3Lilian T. Minja4Lanja Saleh5Medea Imboden6Christian Schindler7Sebastien Gagneux8Claudia Daubenberger9Klaus Reither10Nicole Probst-Hensch11Ifakara Health InstituteInstitute of Social and Preventive Medicine, Lausanne University HospitalShree Hindu Mandal Hospital and Muhimbili University of Health SciencesKinondoni Municipal Council, National Tuberculosis ProgramIfakara Health InstituteInstitute of Clinical Chemistry, University of Zurich, University Hospital of ZurichSwiss Tropical and Public Health InstituteSwiss Tropical and Public Health InstituteSwiss Tropical and Public Health InstituteSwiss Tropical and Public Health InstituteIfakara Health InstituteSwiss Tropical and Public Health InstituteAbstract Background Vitamin D level is inversely associated with tuberculosis (TB) and diabetes (DM). Vitamin D could be a mediator in the association between TB and DM. We examined the associations between vitamin D, TB and DM. Methods Consecutive adults with TB and sex- and age-matched volunteers were included in a case-control study in Dar es Salaam, Tanzania. Glycemia and total vitamin D (25(OH)D) were measured at enrolment and after TB treatment in cases. The association between low 25(OH)D (<75 nmol/l) and TB was evaluated by logistic regression adjusted for age, sex, body mass index, socioeconomic status, sunshine hours, HIV and an interaction between low 25(OH)D and hyperglycemia. Results The prevalence of low 25(OH)D was similar in TB patients and controls (25.8 % versus 31.0 %; p = 0.22). In the subgroup of patients with persistent hyperglycemia (i.e. likely true diabetic patients), the proportion of patients with low 25(OH)D tended to be greater in TB patients (50 % versus 29.7 %; p = 0.20). The effect modification by persistent hyperglycemia persisted in the multivariate analysis (pinteraction = 0.01). Conclusions Low 25(OH)D may increase TB risk in patients with underlying DM. Trials should examine if this association is causal and whether adjunct vitamin D therapy is beneficial in this population.http://link.springer.com/article/10.1186/s12879-016-1960-xStress-induced hyperglycemiaTransient hyperglycemiaTuberculosisVitamin DDiabetes |
| spellingShingle | Noémie Boillat-Blanco Pascal Bovet Kaushik L. Ramaiya Maliwasa Mganga Lilian T. Minja Lanja Saleh Medea Imboden Christian Schindler Sebastien Gagneux Claudia Daubenberger Klaus Reither Nicole Probst-Hensch Association between tuberculosis, diabetes and 25 hydroxyvitamin D in Tanzania: a longitudinal case control study BMC Infectious Diseases Stress-induced hyperglycemia Transient hyperglycemia Tuberculosis Vitamin D Diabetes |
| title | Association between tuberculosis, diabetes and 25 hydroxyvitamin D in Tanzania: a longitudinal case control study |
| title_full | Association between tuberculosis, diabetes and 25 hydroxyvitamin D in Tanzania: a longitudinal case control study |
| title_fullStr | Association between tuberculosis, diabetes and 25 hydroxyvitamin D in Tanzania: a longitudinal case control study |
| title_full_unstemmed | Association between tuberculosis, diabetes and 25 hydroxyvitamin D in Tanzania: a longitudinal case control study |
| title_short | Association between tuberculosis, diabetes and 25 hydroxyvitamin D in Tanzania: a longitudinal case control study |
| title_sort | association between tuberculosis diabetes and 25 hydroxyvitamin d in tanzania a longitudinal case control study |
| topic | Stress-induced hyperglycemia Transient hyperglycemia Tuberculosis Vitamin D Diabetes |
| url | http://link.springer.com/article/10.1186/s12879-016-1960-x |
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