Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells
PIP3 and its phosphatase (PTEN) are enriched mutually exclusively on the anterior and posterior membranes of eukaryotic motile cells. Here authors manipulate PIP3 level and use single-molecule imaging to show that PIP3 suppresses the membrane localization of PTEN.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06856-0 |
| _version_ | 1818684365324943360 |
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| author | Satomi Matsuoka Masahiro Ueda |
| author_facet | Satomi Matsuoka Masahiro Ueda |
| author_sort | Satomi Matsuoka |
| collection | DOAJ |
| description | PIP3 and its phosphatase (PTEN) are enriched mutually exclusively on the anterior and posterior membranes of eukaryotic motile cells. Here authors manipulate PIP3 level and use single-molecule imaging to show that PIP3 suppresses the membrane localization of PTEN. |
| first_indexed | 2024-12-17T10:49:28Z |
| format | Article |
| id | doaj.art-a14ed1724f27488b8b3bd9c279edce37 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:49:28Z |
| publishDate | 2018-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a14ed1724f27488b8b3bd9c279edce372022-12-21T21:52:02ZengNature PortfolioNature Communications2041-17232018-10-019111510.1038/s41467-018-06856-0Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cellsSatomi Matsuoka0Masahiro Ueda1Laboratory for Cell Signaling Dynamics, RIKEN QBiCLaboratory for Cell Signaling Dynamics, RIKEN QBiCPIP3 and its phosphatase (PTEN) are enriched mutually exclusively on the anterior and posterior membranes of eukaryotic motile cells. Here authors manipulate PIP3 level and use single-molecule imaging to show that PIP3 suppresses the membrane localization of PTEN.https://doi.org/10.1038/s41467-018-06856-0 |
| spellingShingle | Satomi Matsuoka Masahiro Ueda Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells Nature Communications |
| title | Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells |
| title_full | Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells |
| title_fullStr | Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells |
| title_full_unstemmed | Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells |
| title_short | Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells |
| title_sort | mutual inhibition between pten and pip3 generates bistability for polarity in motile cells |
| url | https://doi.org/10.1038/s41467-018-06856-0 |
| work_keys_str_mv | AT satomimatsuoka mutualinhibitionbetweenptenandpip3generatesbistabilityforpolarityinmotilecells AT masahiroueda mutualinhibitionbetweenptenandpip3generatesbistabilityforpolarityinmotilecells |