Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1.

Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1.

Vertebrate limb outgrowth is driven by a positive feedback loop that involves Sonic hedgehog (Shh) and Gremlin1 (Grem1) in the posterior limb bud mesenchyme and Fibroblast growth factors (Fgfs) in the overlying epithelium. Proper spatio-temporal control of these signaling activities is required to a...

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Bibliographic Details
Main Authors: Henner F Farin, Timo H-W Lüdtke, Martina K Schmidt, Susann Placzko, Karin Schuster-Gossler, Marianne Petry, Vincent M Christoffels, Andreas Kispert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3636256?pdf=render

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