The role of TGF-β2 in cartilage development and diseases
Transforming growth factor-beta2 (TGF-β2) is recognized as a versatile cytokine that plays a vital role in regulation of joint development, homeostasis, and diseases, but its role as a biological mechanism is understood far less than that of its counterpart, TGF-β1. Cartilage as a load-resisting str...
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| Format: | Article |
| Language: | English |
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The British Editorial Society of Bone & Joint Surgery
2021-08-01
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| Series: | Bone & Joint Research |
| Subjects: | |
| Online Access: | https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.108.BJR-2021-0086 |
| _version_ | 1819016932459806720 |
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| author | Mengmeng Duan Qingxuan Wang Yang Liu Jing Xie |
| author_facet | Mengmeng Duan Qingxuan Wang Yang Liu Jing Xie |
| author_sort | Mengmeng Duan |
| collection | DOAJ |
| description | Transforming growth factor-beta2 (TGF-β2) is recognized as a versatile cytokine that plays a vital role in regulation of joint development, homeostasis, and diseases, but its role as a biological mechanism is understood far less than that of its counterpart, TGF-β1. Cartilage as a load-resisting structure in vertebrates however displays a fragile performance when any tissue disturbance occurs, due to its lack of blood vessels, nerves, and lymphatics. Recent reports have indicated that TGF-β2 is involved in the physiological processes of chondrocytes such as proliferation, differentiation, migration, and apoptosis, and the pathological progress of cartilage such as osteoarthritis (OA) and rheumatoid arthritis (RA). TGF-β2 also shows its potent capacity in the repair of cartilage defects by recruiting autologous mesenchymal stem cells and promoting secretion of other growth factor clusters. In addition, some pioneering studies have already considered it as a potential target in the treatment of OA and RA. This article aims to summarize the current progress of TGF-β2 in cartilage development and diseases, which might provide new cues for remodelling of cartilage defect and intervention of cartilage diseases. |
| first_indexed | 2024-12-21T02:55:29Z |
| format | Article |
| id | doaj.art-a1547d9e7b0f458b9067ebc157ae245f |
| institution | Directory Open Access Journal |
| issn | 2046-3758 |
| language | English |
| last_indexed | 2024-12-21T02:55:29Z |
| publishDate | 2021-08-01 |
| publisher | The British Editorial Society of Bone & Joint Surgery |
| record_format | Article |
| series | Bone & Joint Research |
| spelling | doaj.art-a1547d9e7b0f458b9067ebc157ae245f2022-12-21T19:18:21ZengThe British Editorial Society of Bone & Joint SurgeryBone & Joint Research2046-37582021-08-0110847448710.1302/2046-3758.108.BJR-2021-0086The role of TGF-β2 in cartilage development and diseasesMengmeng Duan0Qingxuan Wang1Yang Liu2Jing Xie3State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaTransforming growth factor-beta2 (TGF-β2) is recognized as a versatile cytokine that plays a vital role in regulation of joint development, homeostasis, and diseases, but its role as a biological mechanism is understood far less than that of its counterpart, TGF-β1. Cartilage as a load-resisting structure in vertebrates however displays a fragile performance when any tissue disturbance occurs, due to its lack of blood vessels, nerves, and lymphatics. Recent reports have indicated that TGF-β2 is involved in the physiological processes of chondrocytes such as proliferation, differentiation, migration, and apoptosis, and the pathological progress of cartilage such as osteoarthritis (OA) and rheumatoid arthritis (RA). TGF-β2 also shows its potent capacity in the repair of cartilage defects by recruiting autologous mesenchymal stem cells and promoting secretion of other growth factor clusters. In addition, some pioneering studies have already considered it as a potential target in the treatment of OA and RA. This article aims to summarize the current progress of TGF-β2 in cartilage development and diseases, which might provide new cues for remodelling of cartilage defect and intervention of cartilage diseases.https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.108.BJR-2021-0086tgf-β2chondrocytecartilage development and diseasescartilage tissuechondrocytescartilage diseasesapoptosisgrowth factorsmesenchymal progenitor cellscartilage defectscytokinesosteoarthritis (oa)blood vessels |
| spellingShingle | Mengmeng Duan Qingxuan Wang Yang Liu Jing Xie The role of TGF-β2 in cartilage development and diseases Bone & Joint Research tgf-β2 chondrocyte cartilage development and diseases cartilage tissue chondrocytes cartilage diseases apoptosis growth factors mesenchymal progenitor cells cartilage defects cytokines osteoarthritis (oa) blood vessels |
| title | The role of TGF-β2 in cartilage development and diseases |
| title_full | The role of TGF-β2 in cartilage development and diseases |
| title_fullStr | The role of TGF-β2 in cartilage development and diseases |
| title_full_unstemmed | The role of TGF-β2 in cartilage development and diseases |
| title_short | The role of TGF-β2 in cartilage development and diseases |
| title_sort | role of tgf β2 in cartilage development and diseases |
| topic | tgf-β2 chondrocyte cartilage development and diseases cartilage tissue chondrocytes cartilage diseases apoptosis growth factors mesenchymal progenitor cells cartilage defects cytokines osteoarthritis (oa) blood vessels |
| url | https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.108.BJR-2021-0086 |
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