DYNAMIC cohort study evaluating metabolic predictors of influenza vaccine immune response in older adults
Abstract Immunosenescence (age-related immune dysfunction) and inflamm-aging contribute to suboptimal immune responses in older adults to standard-dose influenza vaccines, which may be exacerbated in those with metabolic co-morbidities. We sought to investigate metabolic factors/predictors of influe...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
|
| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-022-00548-z |
| _version_ | 1827615031427072000 |
|---|---|
| author | Sapna P. Sadarangani Barnaby E. Young Weixiang Lian Hwee Pin Phua Mark I.-C. Chen Ian Barr Tsin Wen Yeo Rinkoo Dalan Angela Chow |
| author_facet | Sapna P. Sadarangani Barnaby E. Young Weixiang Lian Hwee Pin Phua Mark I.-C. Chen Ian Barr Tsin Wen Yeo Rinkoo Dalan Angela Chow |
| author_sort | Sapna P. Sadarangani |
| collection | DOAJ |
| description | Abstract Immunosenescence (age-related immune dysfunction) and inflamm-aging contribute to suboptimal immune responses in older adults to standard-dose influenza vaccines, which may be exacerbated in those with metabolic co-morbidities. We sought to investigate metabolic factors/predictors of influenza vaccine immune response in an older adult (age ≥65 years) cohort in Singapore, where influenza typically circulates year-round. The primary outcome for the DYNAMIC prospective cohort study was haemagglutination-inhibition titer (HAI) response to each of the trivalent inactivated influenza vaccine strains at day 28 (D28) compared to baseline (D0), as assessed by seroconversion and D28/D0 log2 HAI fold rise. Baseline blood samples were tested for total Vitamin D (25-(OH) D) levels. We enrolled 234 participants in June–Dec 2017. Two hundred twenty completed all study visits. The median age was 71 [IQR 68–75] years, 67 (30.5%) had diabetes mellitus (DM), and the median BMI was 24.9 [IQR 22.2–27.8] kg/m2. Median baseline totals 25-(OH) D was 29 [IQR: 21–29] ng/ml. Age, DM, obesity, and baseline 25-(OH) D were not associated with HAI fold rise in multivariable analysis. More recent prior influenza vaccination and higher baseline HAI titers were associated with lower HAI fold rise for influenza A/HK/H3N2. Physical activity was associated with a higher HAI fold rise for influenza A/HK/H3N2 in a dose-response relationship (p-test for trend = 0.015). Older adults with well-controlled metabolic co-morbidities retain HAI response to the influenza vaccine, and physical activity had a beneficial effect on immune response, particularly for influenza A/HK/H3N2. |
| first_indexed | 2024-03-09T09:04:21Z |
| format | Article |
| id | doaj.art-a157b900faf24e7aaf6e0f8182f82b42 |
| institution | Directory Open Access Journal |
| issn | 2059-0105 |
| language | English |
| last_indexed | 2024-03-09T09:04:21Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj.art-a157b900faf24e7aaf6e0f8182f82b422023-12-02T10:47:21ZengNature Portfolionpj Vaccines2059-01052022-11-01711910.1038/s41541-022-00548-zDYNAMIC cohort study evaluating metabolic predictors of influenza vaccine immune response in older adultsSapna P. Sadarangani0Barnaby E. Young1Weixiang Lian2Hwee Pin Phua3Mark I.-C. Chen4Ian Barr5Tsin Wen Yeo6Rinkoo Dalan7Angela Chow8National Centre for Infectious DiseasesNational Centre for Infectious DiseasesDepartment of Preventive and Population Medicine, Office of Clinical Epidemiology, Analytics and Knowledge (OCEAN), Tan Tock Seng HospitalDepartment of Preventive and Population Medicine, Office of Clinical Epidemiology, Analytics and Knowledge (OCEAN), Tan Tock Seng HospitalNational Centre for Infectious DiseasesWHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and ImmunityNational Centre for Infectious DiseasesLee Kong Chian School of Medicine, Nanyang Technological UniversityLee Kong Chian School of Medicine, Nanyang Technological UniversityAbstract Immunosenescence (age-related immune dysfunction) and inflamm-aging contribute to suboptimal immune responses in older adults to standard-dose influenza vaccines, which may be exacerbated in those with metabolic co-morbidities. We sought to investigate metabolic factors/predictors of influenza vaccine immune response in an older adult (age ≥65 years) cohort in Singapore, where influenza typically circulates year-round. The primary outcome for the DYNAMIC prospective cohort study was haemagglutination-inhibition titer (HAI) response to each of the trivalent inactivated influenza vaccine strains at day 28 (D28) compared to baseline (D0), as assessed by seroconversion and D28/D0 log2 HAI fold rise. Baseline blood samples were tested for total Vitamin D (25-(OH) D) levels. We enrolled 234 participants in June–Dec 2017. Two hundred twenty completed all study visits. The median age was 71 [IQR 68–75] years, 67 (30.5%) had diabetes mellitus (DM), and the median BMI was 24.9 [IQR 22.2–27.8] kg/m2. Median baseline totals 25-(OH) D was 29 [IQR: 21–29] ng/ml. Age, DM, obesity, and baseline 25-(OH) D were not associated with HAI fold rise in multivariable analysis. More recent prior influenza vaccination and higher baseline HAI titers were associated with lower HAI fold rise for influenza A/HK/H3N2. Physical activity was associated with a higher HAI fold rise for influenza A/HK/H3N2 in a dose-response relationship (p-test for trend = 0.015). Older adults with well-controlled metabolic co-morbidities retain HAI response to the influenza vaccine, and physical activity had a beneficial effect on immune response, particularly for influenza A/HK/H3N2.https://doi.org/10.1038/s41541-022-00548-z |
| spellingShingle | Sapna P. Sadarangani Barnaby E. Young Weixiang Lian Hwee Pin Phua Mark I.-C. Chen Ian Barr Tsin Wen Yeo Rinkoo Dalan Angela Chow DYNAMIC cohort study evaluating metabolic predictors of influenza vaccine immune response in older adults npj Vaccines |
| title | DYNAMIC cohort study evaluating metabolic predictors of influenza vaccine immune response in older adults |
| title_full | DYNAMIC cohort study evaluating metabolic predictors of influenza vaccine immune response in older adults |
| title_fullStr | DYNAMIC cohort study evaluating metabolic predictors of influenza vaccine immune response in older adults |
| title_full_unstemmed | DYNAMIC cohort study evaluating metabolic predictors of influenza vaccine immune response in older adults |
| title_short | DYNAMIC cohort study evaluating metabolic predictors of influenza vaccine immune response in older adults |
| title_sort | dynamic cohort study evaluating metabolic predictors of influenza vaccine immune response in older adults |
| url | https://doi.org/10.1038/s41541-022-00548-z |
| work_keys_str_mv | AT sapnapsadarangani dynamiccohortstudyevaluatingmetabolicpredictorsofinfluenzavaccineimmuneresponseinolderadults AT barnabyeyoung dynamiccohortstudyevaluatingmetabolicpredictorsofinfluenzavaccineimmuneresponseinolderadults AT weixianglian dynamiccohortstudyevaluatingmetabolicpredictorsofinfluenzavaccineimmuneresponseinolderadults AT hweepinphua dynamiccohortstudyevaluatingmetabolicpredictorsofinfluenzavaccineimmuneresponseinolderadults AT markicchen dynamiccohortstudyevaluatingmetabolicpredictorsofinfluenzavaccineimmuneresponseinolderadults AT ianbarr dynamiccohortstudyevaluatingmetabolicpredictorsofinfluenzavaccineimmuneresponseinolderadults AT tsinwenyeo dynamiccohortstudyevaluatingmetabolicpredictorsofinfluenzavaccineimmuneresponseinolderadults AT rinkoodalan dynamiccohortstudyevaluatingmetabolicpredictorsofinfluenzavaccineimmuneresponseinolderadults AT angelachow dynamiccohortstudyevaluatingmetabolicpredictorsofinfluenzavaccineimmuneresponseinolderadults |