IVF pregnancy after kidney transplantation: clinical case and literature review
Kidney transplantation (KT), the optimal treatment for stage 5 chronic kidney disease (CKD), restores impaired fertility in most women of reproductive age. However, infertility occurs in some patients after successful KT. We present our own experience of overcoming secondary tubal infertility by in...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2022-12-01
|
| Series: | Вестник трансплантологии и искусственных органов |
| Subjects: | |
| Online Access: | https://journal.transpl.ru/vtio/article/view/1554 |
| _version_ | 1826546311203127296 |
|---|---|
| author | E. I. Prokopenko V. M. Guryeva V. A. Petrukhin K. V. Krasnopol’skaya F. F. Burumkulova D. V. Gubina |
| author_facet | E. I. Prokopenko V. M. Guryeva V. A. Petrukhin K. V. Krasnopol’skaya F. F. Burumkulova D. V. Gubina |
| author_sort | E. I. Prokopenko |
| collection | DOAJ |
| description | Kidney transplantation (KT), the optimal treatment for stage 5 chronic kidney disease (CKD), restores impaired fertility in most women of reproductive age. However, infertility occurs in some patients after successful KT. We present our own experience of overcoming secondary tubal infertility by in vitro fertilization (IVF). The patient was a 36-year-old with a transplanted kidney, who had lost two pregnancies in the past due to severe preeclampsia (PE). After the second attempt on cryo-thawed embryo transfer against the background of hormone replacement therapy, one embryo was transferred into the uterus, resulting in pregnancy. Gestational diabetes mellitus (GDM) was diagnosed in the first trimester, and a diet was prescribed. Immunosuppression with tacrolimus, azathioprine and methylprednisolone, prophylaxis of PE with low molecular weight heparin and antiplatelet drugs were administered during pregnancy. Elective cesarean section was performed at 37–38 weeks and a healthy boy was born, weighing 2760 g (25th percentile), 48 cm tall (36th percentile). A stay in the neonatal intensive care unit was not required. The baby is growing and developing normally, the mother’s renal graft function is satisfactory. So, IVF can be successfully used in post-KT patients with infertility issues, provided that the IVF program is carefully controlled, and the pregnancy is managed in a multidisciplinary manner. |
| first_indexed | 2024-04-10T00:50:56Z |
| format | Article |
| id | doaj.art-a15871a80eba4640bbfe4cc7dc436ff6 |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2025-03-14T05:31:44Z |
| publishDate | 2022-12-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj.art-a15871a80eba4640bbfe4cc7dc436ff62025-03-05T14:11:53ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912022-12-01244152310.15825/1995-1191-2022-4-15-231131IVF pregnancy after kidney transplantation: clinical case and literature reviewE. I. Prokopenko0V. M. Guryeva1V. A. Petrukhin2K. V. Krasnopol’skaya3F. F. Burumkulova4D. V. Gubina5Vladimirsky Moscow Regional Research Clinical Institute; Moscow Regional Research Institute of Obstetrics and GynecologyMoscow Regional Research Institute of Obstetrics and GynecologyMoscow Regional Research Institute of Obstetrics and GynecologyMoscow Regional Research Institute of Obstetrics and GynecologyMoscow Regional Research Institute of Obstetrics and GynecologyVladimirsky Moscow Regional Research Clinical InstituteKidney transplantation (KT), the optimal treatment for stage 5 chronic kidney disease (CKD), restores impaired fertility in most women of reproductive age. However, infertility occurs in some patients after successful KT. We present our own experience of overcoming secondary tubal infertility by in vitro fertilization (IVF). The patient was a 36-year-old with a transplanted kidney, who had lost two pregnancies in the past due to severe preeclampsia (PE). After the second attempt on cryo-thawed embryo transfer against the background of hormone replacement therapy, one embryo was transferred into the uterus, resulting in pregnancy. Gestational diabetes mellitus (GDM) was diagnosed in the first trimester, and a diet was prescribed. Immunosuppression with tacrolimus, azathioprine and methylprednisolone, prophylaxis of PE with low molecular weight heparin and antiplatelet drugs were administered during pregnancy. Elective cesarean section was performed at 37–38 weeks and a healthy boy was born, weighing 2760 g (25th percentile), 48 cm tall (36th percentile). A stay in the neonatal intensive care unit was not required. The baby is growing and developing normally, the mother’s renal graft function is satisfactory. So, IVF can be successfully used in post-KT patients with infertility issues, provided that the IVF program is carefully controlled, and the pregnancy is managed in a multidisciplinary manner.https://journal.transpl.ru/vtio/article/view/1554kidney transplantationinfertilitypregnancyassisted reproductive technologyin vitro fertilization |
| spellingShingle | E. I. Prokopenko V. M. Guryeva V. A. Petrukhin K. V. Krasnopol’skaya F. F. Burumkulova D. V. Gubina IVF pregnancy after kidney transplantation: clinical case and literature review Вестник трансплантологии и искусственных органов kidney transplantation infertility pregnancy assisted reproductive technology in vitro fertilization |
| title | IVF pregnancy after kidney transplantation: clinical case and literature review |
| title_full | IVF pregnancy after kidney transplantation: clinical case and literature review |
| title_fullStr | IVF pregnancy after kidney transplantation: clinical case and literature review |
| title_full_unstemmed | IVF pregnancy after kidney transplantation: clinical case and literature review |
| title_short | IVF pregnancy after kidney transplantation: clinical case and literature review |
| title_sort | ivf pregnancy after kidney transplantation clinical case and literature review |
| topic | kidney transplantation infertility pregnancy assisted reproductive technology in vitro fertilization |
| url | https://journal.transpl.ru/vtio/article/view/1554 |
| work_keys_str_mv | AT eiprokopenko ivfpregnancyafterkidneytransplantationclinicalcaseandliteraturereview AT vmguryeva ivfpregnancyafterkidneytransplantationclinicalcaseandliteraturereview AT vapetrukhin ivfpregnancyafterkidneytransplantationclinicalcaseandliteraturereview AT kvkrasnopolskaya ivfpregnancyafterkidneytransplantationclinicalcaseandliteraturereview AT ffburumkulova ivfpregnancyafterkidneytransplantationclinicalcaseandliteraturereview AT dvgubina ivfpregnancyafterkidneytransplantationclinicalcaseandliteraturereview |