Comparison of Mean Arterial Blood Pressure and Heart Rate Changes in Response to Three Different Randomized Isotonic Crystalloid Boluses in Hypotensive Anesthetized Dogs
The aim of this prospective, randomized, nonblinded, controlled clinical trial was to compare mean arterial blood pressure (MAP) and heart rate (HR) during an intravenous bolus of three different balanced isotonic crystalloid solutions in euvolemic, anesthetized dogs with hypotension. Thirty healthy...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/12/14/1781 |
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| author | Raphaël Vézina-Audette Marta Kantyka Giacomo Gianotti Deborah C. Silverstein |
| author_facet | Raphaël Vézina-Audette Marta Kantyka Giacomo Gianotti Deborah C. Silverstein |
| author_sort | Raphaël Vézina-Audette |
| collection | DOAJ |
| description | The aim of this prospective, randomized, nonblinded, controlled clinical trial was to compare mean arterial blood pressure (MAP) and heart rate (HR) during an intravenous bolus of three different balanced isotonic crystalloid solutions in euvolemic, anesthetized dogs with hypotension. Thirty healthy dogs (American Society of Anesthesiologists Physical Status I–II) weighing at least 15 kg that presented for elective orthopedic or dental surgical procedures at the Ryan Veterinary Hospital for Small Animals of the University of Pennsylvania were included in this study. Anesthetized hypotensive patients (defined as a MAP ≤ 65 mmHg), were administered an infusion of Lactated Ringer’s solution (LRS), Plasma-Lyte (PLYTE) or Canadian Plasma-Lyte (PLYTECA), selected at random. The infusion was administered over 15 min via a volumetric fluid pump. Differences in oscillometric MAP and HR between time points and across treatments were evaluated by mANOVA. Intravenous isotonic crystalloid infusions over 15 min did not significantly change MAP or HR in hypotensive dogs under general anesthesia. Neither LRS, PLYTE nor PLYTECA exacerbated hypotension or caused tachycardia. |
| first_indexed | 2024-03-09T10:24:29Z |
| format | Article |
| id | doaj.art-a15b52e9aaba40de8ddf209d03b3faa2 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T10:24:29Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-a15b52e9aaba40de8ddf209d03b3faa22023-12-01T21:48:22ZengMDPI AGAnimals2076-26152022-07-011214178110.3390/ani12141781Comparison of Mean Arterial Blood Pressure and Heart Rate Changes in Response to Three Different Randomized Isotonic Crystalloid Boluses in Hypotensive Anesthetized DogsRaphaël Vézina-Audette0Marta Kantyka1Giacomo Gianotti2Deborah C. Silverstein3Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital, 3900 Delancey Street, University of Pennsylvania, Philadelphia, PA 19104, USASection of Anaesthesiology and Pain Therapy, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, 3012 Bern, SwitzerlandDepartment of Clinical Studies, Matthew J. Ryan Veterinary Hospital, 3900 Delancey Street, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Clinical Studies, Matthew J. Ryan Veterinary Hospital, 3900 Delancey Street, University of Pennsylvania, Philadelphia, PA 19104, USAThe aim of this prospective, randomized, nonblinded, controlled clinical trial was to compare mean arterial blood pressure (MAP) and heart rate (HR) during an intravenous bolus of three different balanced isotonic crystalloid solutions in euvolemic, anesthetized dogs with hypotension. Thirty healthy dogs (American Society of Anesthesiologists Physical Status I–II) weighing at least 15 kg that presented for elective orthopedic or dental surgical procedures at the Ryan Veterinary Hospital for Small Animals of the University of Pennsylvania were included in this study. Anesthetized hypotensive patients (defined as a MAP ≤ 65 mmHg), were administered an infusion of Lactated Ringer’s solution (LRS), Plasma-Lyte (PLYTE) or Canadian Plasma-Lyte (PLYTECA), selected at random. The infusion was administered over 15 min via a volumetric fluid pump. Differences in oscillometric MAP and HR between time points and across treatments were evaluated by mANOVA. Intravenous isotonic crystalloid infusions over 15 min did not significantly change MAP or HR in hypotensive dogs under general anesthesia. Neither LRS, PLYTE nor PLYTECA exacerbated hypotension or caused tachycardia.https://www.mdpi.com/2076-2615/12/14/1781hypotensionfluid therapyinhalant anesthesia |
| spellingShingle | Raphaël Vézina-Audette Marta Kantyka Giacomo Gianotti Deborah C. Silverstein Comparison of Mean Arterial Blood Pressure and Heart Rate Changes in Response to Three Different Randomized Isotonic Crystalloid Boluses in Hypotensive Anesthetized Dogs Animals hypotension fluid therapy inhalant anesthesia |
| title | Comparison of Mean Arterial Blood Pressure and Heart Rate Changes in Response to Three Different Randomized Isotonic Crystalloid Boluses in Hypotensive Anesthetized Dogs |
| title_full | Comparison of Mean Arterial Blood Pressure and Heart Rate Changes in Response to Three Different Randomized Isotonic Crystalloid Boluses in Hypotensive Anesthetized Dogs |
| title_fullStr | Comparison of Mean Arterial Blood Pressure and Heart Rate Changes in Response to Three Different Randomized Isotonic Crystalloid Boluses in Hypotensive Anesthetized Dogs |
| title_full_unstemmed | Comparison of Mean Arterial Blood Pressure and Heart Rate Changes in Response to Three Different Randomized Isotonic Crystalloid Boluses in Hypotensive Anesthetized Dogs |
| title_short | Comparison of Mean Arterial Blood Pressure and Heart Rate Changes in Response to Three Different Randomized Isotonic Crystalloid Boluses in Hypotensive Anesthetized Dogs |
| title_sort | comparison of mean arterial blood pressure and heart rate changes in response to three different randomized isotonic crystalloid boluses in hypotensive anesthetized dogs |
| topic | hypotension fluid therapy inhalant anesthesia |
| url | https://www.mdpi.com/2076-2615/12/14/1781 |
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