Low-Intensity Transcranial Ultrasound Stimulation: Mechanisms of Action and Rationale for Future Applications in Movement Disorders
Low-intensity transcranial ultrasound stimulation (TUS) is a novel non-invasive brain stimulation technique that uses acoustic energy to induce changes in neuronal activity. However, although low-intensity TUS is a promising neuromodulation tool, it has been poorly studied as compared to other metho...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/12/5/611 |
| _version_ | 1797501190024462336 |
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| author | Andrea Guerra Matteo Bologna |
| author_facet | Andrea Guerra Matteo Bologna |
| author_sort | Andrea Guerra |
| collection | DOAJ |
| description | Low-intensity transcranial ultrasound stimulation (TUS) is a novel non-invasive brain stimulation technique that uses acoustic energy to induce changes in neuronal activity. However, although low-intensity TUS is a promising neuromodulation tool, it has been poorly studied as compared to other methods, i.e., transcranial magnetic and electrical stimulation. In this article, we first focus on experimental studies in animals and humans aimed at explaining its mechanisms of action. We then highlight possible applications of TUS in movement disorders, particularly in patients with parkinsonism, dystonia, and tremor. Finally, we highlight the knowledge gaps and possible limitations that currently limit potential TUS applications in movement disorders. Clarifying the potential role of TUS in movement disorders may further promote studies with therapeutic perspectives in this field. |
| first_indexed | 2024-03-10T03:14:48Z |
| format | Article |
| id | doaj.art-a15ca8a06abc4ebea995903356792909 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T03:14:48Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-a15ca8a06abc4ebea9959033567929092023-11-23T10:17:52ZengMDPI AGBrain Sciences2076-34252022-05-0112561110.3390/brainsci12050611Low-Intensity Transcranial Ultrasound Stimulation: Mechanisms of Action and Rationale for Future Applications in Movement DisordersAndrea Guerra0Matteo Bologna1IRCCS Neuromed, 86077 Pozzilli, ItalyIRCCS Neuromed, 86077 Pozzilli, ItalyLow-intensity transcranial ultrasound stimulation (TUS) is a novel non-invasive brain stimulation technique that uses acoustic energy to induce changes in neuronal activity. However, although low-intensity TUS is a promising neuromodulation tool, it has been poorly studied as compared to other methods, i.e., transcranial magnetic and electrical stimulation. In this article, we first focus on experimental studies in animals and humans aimed at explaining its mechanisms of action. We then highlight possible applications of TUS in movement disorders, particularly in patients with parkinsonism, dystonia, and tremor. Finally, we highlight the knowledge gaps and possible limitations that currently limit potential TUS applications in movement disorders. Clarifying the potential role of TUS in movement disorders may further promote studies with therapeutic perspectives in this field.https://www.mdpi.com/2076-3425/12/5/611transcranial ultrasound stimulationTUSmovement disordersParkinson’s diseaseessential tremordystonia |
| spellingShingle | Andrea Guerra Matteo Bologna Low-Intensity Transcranial Ultrasound Stimulation: Mechanisms of Action and Rationale for Future Applications in Movement Disorders Brain Sciences transcranial ultrasound stimulation TUS movement disorders Parkinson’s disease essential tremor dystonia |
| title | Low-Intensity Transcranial Ultrasound Stimulation: Mechanisms of Action and Rationale for Future Applications in Movement Disorders |
| title_full | Low-Intensity Transcranial Ultrasound Stimulation: Mechanisms of Action and Rationale for Future Applications in Movement Disorders |
| title_fullStr | Low-Intensity Transcranial Ultrasound Stimulation: Mechanisms of Action and Rationale for Future Applications in Movement Disorders |
| title_full_unstemmed | Low-Intensity Transcranial Ultrasound Stimulation: Mechanisms of Action and Rationale for Future Applications in Movement Disorders |
| title_short | Low-Intensity Transcranial Ultrasound Stimulation: Mechanisms of Action and Rationale for Future Applications in Movement Disorders |
| title_sort | low intensity transcranial ultrasound stimulation mechanisms of action and rationale for future applications in movement disorders |
| topic | transcranial ultrasound stimulation TUS movement disorders Parkinson’s disease essential tremor dystonia |
| url | https://www.mdpi.com/2076-3425/12/5/611 |
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