Mechanistic and therapeutic insight into the effects of cinnamon in polycystic ovary syndrome: a systematic review
Abstract Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases in the women at their reproductive age. Nowadays, the use of herbal compounds for lesser side effects, as compared to drug treatments, has become popular for the prevention and reduction of the complications of th...
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13048-021-00870-5 |
| _version_ | 1797969849536741376 |
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| author | Vahid Maleki Amir Hossein Faghfouri Fatemeh Pourteymour Fard Tabrizi Jalal Moludi Sevda Saleh-Ghadimi Hamed Jafari-Vayghan Shaimaa A. Qaisar |
| author_facet | Vahid Maleki Amir Hossein Faghfouri Fatemeh Pourteymour Fard Tabrizi Jalal Moludi Sevda Saleh-Ghadimi Hamed Jafari-Vayghan Shaimaa A. Qaisar |
| author_sort | Vahid Maleki |
| collection | DOAJ |
| description | Abstract Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases in the women at their reproductive age. Nowadays, the use of herbal compounds for lesser side effects, as compared to drug treatments, has become popular for the prevention and reduction of the complications of this disease. Evidence suggests that cinnamon, given its antioxidant and anti-inflammatory properties, can be associated with reduced metabolic complications from chronic non-communicable diseases. This systematic review aimed to determine the potential effect of cinnamon on the metabolic status in the PCOS. PICO framework for current systematic review was Population (P): subjects with PCOS; Intervention (I): oral cinnamon supplement; Comparison (C): the group as control or administered placebo; and Outcome (O): changed inflammatory, oxidative stress, lipid profile, glycemic, hormonal and anthropometric parameters and ovarian function. PubMed, Scopus, EMBASE, ProQuest and Google Scholar were searched from their very inception until January, 2020, considering specific keywords to explore the related studies. Out of 266 studies retrieved by the search strategy, only nine were eligible for evaluation. All clinical trials, animal studies, and published English-language journal studies were eligible for this review. The results showed that increased high-density lipoprotein and insulin sensitivity were increased by the cinnamon supplementation while low-density lipoprotein, triglyceride, and blood glucose were decreased in patients with PCOS. However, the results related to the potential effects of cinnamon on body weight and body mass index were inconsistent, thus calling for further studies. Also, despite improved results regarding the effect of cinnamon on oxidative stress and ovarian function, further studies are required to explore the precise mechanisms. Overall, the effects of cinnamon on the improvement of metabolic status in PCOS were promising. However, to observe clinical changes following cinnamon supplementation in PCOS, more clinical trials with higher doses of cinnamon and a longer duration of intervention are needed. |
| first_indexed | 2024-04-11T03:08:35Z |
| format | Article |
| id | doaj.art-a15f9a10d1d74e99b36e8f12919ebc29 |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T03:08:35Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-a15f9a10d1d74e99b36e8f12919ebc292023-01-02T12:23:38ZengBMCJournal of Ovarian Research1757-22152021-10-0114111410.1186/s13048-021-00870-5Mechanistic and therapeutic insight into the effects of cinnamon in polycystic ovary syndrome: a systematic reviewVahid Maleki0Amir Hossein Faghfouri1Fatemeh Pourteymour Fard Tabrizi2Jalal Moludi3Sevda Saleh-Ghadimi4Hamed Jafari-Vayghan5Shaimaa A. Qaisar6Clinical Cancer Research Center, Milad General HospitalStudent Research Committee,Tabriz University of Medical SciencesNutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical SciencesFaculty of Nutritional Sciences and Food Technology, Kermanshah University of Medical SciencesNutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical SciencesDepartment of Nutrition, Faculty of Health, Arak University of Medical SciencesChemistry Department, College of Education, University of GarmianAbstract Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases in the women at their reproductive age. Nowadays, the use of herbal compounds for lesser side effects, as compared to drug treatments, has become popular for the prevention and reduction of the complications of this disease. Evidence suggests that cinnamon, given its antioxidant and anti-inflammatory properties, can be associated with reduced metabolic complications from chronic non-communicable diseases. This systematic review aimed to determine the potential effect of cinnamon on the metabolic status in the PCOS. PICO framework for current systematic review was Population (P): subjects with PCOS; Intervention (I): oral cinnamon supplement; Comparison (C): the group as control or administered placebo; and Outcome (O): changed inflammatory, oxidative stress, lipid profile, glycemic, hormonal and anthropometric parameters and ovarian function. PubMed, Scopus, EMBASE, ProQuest and Google Scholar were searched from their very inception until January, 2020, considering specific keywords to explore the related studies. Out of 266 studies retrieved by the search strategy, only nine were eligible for evaluation. All clinical trials, animal studies, and published English-language journal studies were eligible for this review. The results showed that increased high-density lipoprotein and insulin sensitivity were increased by the cinnamon supplementation while low-density lipoprotein, triglyceride, and blood glucose were decreased in patients with PCOS. However, the results related to the potential effects of cinnamon on body weight and body mass index were inconsistent, thus calling for further studies. Also, despite improved results regarding the effect of cinnamon on oxidative stress and ovarian function, further studies are required to explore the precise mechanisms. Overall, the effects of cinnamon on the improvement of metabolic status in PCOS were promising. However, to observe clinical changes following cinnamon supplementation in PCOS, more clinical trials with higher doses of cinnamon and a longer duration of intervention are needed.https://doi.org/10.1186/s13048-021-00870-5CinnamonPolycystic Ovary SyndromeLipid ProfileInsulin ResistanceOxidative Stress |
| spellingShingle | Vahid Maleki Amir Hossein Faghfouri Fatemeh Pourteymour Fard Tabrizi Jalal Moludi Sevda Saleh-Ghadimi Hamed Jafari-Vayghan Shaimaa A. Qaisar Mechanistic and therapeutic insight into the effects of cinnamon in polycystic ovary syndrome: a systematic review Journal of Ovarian Research Cinnamon Polycystic Ovary Syndrome Lipid Profile Insulin Resistance Oxidative Stress |
| title | Mechanistic and therapeutic insight into the effects of cinnamon in polycystic ovary syndrome: a systematic review |
| title_full | Mechanistic and therapeutic insight into the effects of cinnamon in polycystic ovary syndrome: a systematic review |
| title_fullStr | Mechanistic and therapeutic insight into the effects of cinnamon in polycystic ovary syndrome: a systematic review |
| title_full_unstemmed | Mechanistic and therapeutic insight into the effects of cinnamon in polycystic ovary syndrome: a systematic review |
| title_short | Mechanistic and therapeutic insight into the effects of cinnamon in polycystic ovary syndrome: a systematic review |
| title_sort | mechanistic and therapeutic insight into the effects of cinnamon in polycystic ovary syndrome a systematic review |
| topic | Cinnamon Polycystic Ovary Syndrome Lipid Profile Insulin Resistance Oxidative Stress |
| url | https://doi.org/10.1186/s13048-021-00870-5 |
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