BACE1 RNAi restores the composition of phosphatidylethanolamine-derivates related to memory improvement in aged 3xTg-AD mice

BACE1 RNAi restores the composition of phosphatidylethanolamine-derivates related to memory improvement in aged 3xTg-AD mice

β-amyloid (Aβ) is produced by the β-secretase 1 (BACE1)-mediated enzymatic cleavage of the amyloid precursor protein through the amyloidogenic pathway, making BACE1 a therapeutic target against Alzheimer’s Disease (AD). Alterations in lipid metabolism are a risk factor for AD by an unknown mechanism...

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Bibliographic Details
Main Authors:	Javier Gustavo Villamil, Alvaro Barrera-Ocampo, Diego Piedrahita, Claudia Maria Velasquez-Rodriguez, Julian David Arias-Londoño, Gloria Patricia Cardona Gomez
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2016-11-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	Hippocampus Phospholipids RNA Interference Alzheimer’s disease Cognitive Function BACE1
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00260/full

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