Coating bacteria for anti-tumor therapy
Therapeutic bacteria have shown great potential on anti-tumor therapy. Compared with traditional therapeutic strategy, living bacteria present unique advantages. Bacteria show high targeting and great colonization ability in tumor microenvironment with hypoxic and nutritious conditions. Bacterial-me...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1020020/full |
| _version_ | 1811261821242310656 |
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| author | Jiahui Wang Ning Guo Weiliang Hou Weiliang Hou Huanlong Qin |
| author_facet | Jiahui Wang Ning Guo Weiliang Hou Weiliang Hou Huanlong Qin |
| author_sort | Jiahui Wang |
| collection | DOAJ |
| description | Therapeutic bacteria have shown great potential on anti-tumor therapy. Compared with traditional therapeutic strategy, living bacteria present unique advantages. Bacteria show high targeting and great colonization ability in tumor microenvironment with hypoxic and nutritious conditions. Bacterial-medicated antitumor therapy has been successfully applied on mouse models, but the low therapeutic effect and biosafe limit its application on clinical treatment. With the development of material science, coating living bacteria with suitable materials has received widespread attention to achieve synergetic therapy on tumor. In this review, we summarize various materials for coating living bacteria in cancer therapy and envision the opportunities and challenges of bacteria-medicated antitumor therapy. |
| first_indexed | 2024-04-12T19:12:48Z |
| format | Article |
| id | doaj.art-a1607b98036443829194e6c389399bae |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T19:12:48Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-a1607b98036443829194e6c389399bae2022-12-22T03:19:50ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-09-011010.3389/fbioe.2022.10200201020020Coating bacteria for anti-tumor therapyJiahui Wang0Ning Guo1Weiliang Hou2Weiliang Hou3Huanlong Qin4Department of Gastrointestinal Surgery, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, ChinaDepartment of Gastrointestinal Surgery, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, ChinaDepartment of Gastrointestinal Surgery, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, ChinaShanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Gastrointestinal Surgery, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, ChinaTherapeutic bacteria have shown great potential on anti-tumor therapy. Compared with traditional therapeutic strategy, living bacteria present unique advantages. Bacteria show high targeting and great colonization ability in tumor microenvironment with hypoxic and nutritious conditions. Bacterial-medicated antitumor therapy has been successfully applied on mouse models, but the low therapeutic effect and biosafe limit its application on clinical treatment. With the development of material science, coating living bacteria with suitable materials has received widespread attention to achieve synergetic therapy on tumor. In this review, we summarize various materials for coating living bacteria in cancer therapy and envision the opportunities and challenges of bacteria-medicated antitumor therapy.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1020020/fulltumor therapytumor targetingcoatingbacteriamaterials |
| spellingShingle | Jiahui Wang Ning Guo Weiliang Hou Weiliang Hou Huanlong Qin Coating bacteria for anti-tumor therapy Frontiers in Bioengineering and Biotechnology tumor therapy tumor targeting coating bacteria materials |
| title | Coating bacteria for anti-tumor therapy |
| title_full | Coating bacteria for anti-tumor therapy |
| title_fullStr | Coating bacteria for anti-tumor therapy |
| title_full_unstemmed | Coating bacteria for anti-tumor therapy |
| title_short | Coating bacteria for anti-tumor therapy |
| title_sort | coating bacteria for anti tumor therapy |
| topic | tumor therapy tumor targeting coating bacteria materials |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1020020/full |
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