Adipose Triglyceride Lipase Deficiency Attenuates In Vitro Thrombus Formation without Affecting Platelet Activation and Bleeding In Vivo

Adipose Triglyceride Lipase Deficiency Attenuates In Vitro Thrombus Formation without Affecting Platelet Activation and Bleeding In Vivo

According to genome-wide RNA sequencing data from human and mouse platelets, adipose triglyceride lipase (ATGL), the main lipase catalyzing triglyceride (TG) hydrolysis in cytosolic lipid droplets (LD) at neutral pH, is expressed in platelets. Currently, it is elusive to whether common lipolytic enz...

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Bibliographic Details
Main Authors: Madeleine Goeritzer, Stefanie Schlager, Katharina B. Kuentzel, Nemanja Vujić, Melanie Korbelius, Silvia Rainer, Dagmar Kolb, Marion Mussbacher, Manuel Salzmann, Waltraud C. Schrottmaier, Alice Assinger, Axel Schlagenhauf, Corina T. Madreiter-Sokolowski, Sandra Blass, Thomas O. Eichmann, Wolfgang F. Graier, Dagmar Kratky
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
platelets
adipose triglyceride lipase
thrombosis
mitochondrial respiration
intravital microscopy
Online Access:https://www.mdpi.com/2073-4409/11/5/850

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