Recent Advances in Decellularized Extracellular Matrix-Based Bioinks for 3D Bioprinting in Tissue Engineering
In recent years, three-dimensional (3D) bioprinting has been widely utilized as a novel manufacturing technique by more and more researchers to construct various tissue substitutes with complex architectures and geometries. Different biomaterials, including natural and synthetic materials, have been...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Materials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1996-1944/16/8/3197 |
| _version_ | 1797604545241546752 |
|---|---|
| author | Man Zhe Xinyu Wu Peiyun Yu Jiawei Xu Ming Liu Guang Yang Zhou Xiang Fei Xing Ulrike Ritz |
| author_facet | Man Zhe Xinyu Wu Peiyun Yu Jiawei Xu Ming Liu Guang Yang Zhou Xiang Fei Xing Ulrike Ritz |
| author_sort | Man Zhe |
| collection | DOAJ |
| description | In recent years, three-dimensional (3D) bioprinting has been widely utilized as a novel manufacturing technique by more and more researchers to construct various tissue substitutes with complex architectures and geometries. Different biomaterials, including natural and synthetic materials, have been manufactured into bioinks for tissue regeneration using 3D bioprinting. Among the natural biomaterials derived from various natural tissues or organs, the decellularized extracellular matrix (dECM) has a complex internal structure and a variety of bioactive factors that provide mechanistic, biophysical, and biochemical signals for tissue regeneration and remodeling. In recent years, more and more researchers have been developing the dECM as a novel bioink for the construction of tissue substitutes. Compared with other bioinks, the various ECM components in dECM-based bioink can regulate cellular functions, modulate the tissue regeneration process, and adjust tissue remodeling. Therefore, we conducted this review to discuss the current status of and perspectives on dECM-based bioinks for bioprinting in tissue engineering. In addition, the various bioprinting techniques and decellularization methods were also discussed in this study. |
| first_indexed | 2024-03-11T04:47:49Z |
| format | Article |
| id | doaj.art-a16203b7429c489a9bc03b1e736fcee7 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-11T04:47:49Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-a16203b7429c489a9bc03b1e736fcee72023-11-17T20:14:33ZengMDPI AGMaterials1996-19442023-04-01168319710.3390/ma16083197Recent Advances in Decellularized Extracellular Matrix-Based Bioinks for 3D Bioprinting in Tissue EngineeringMan Zhe0Xinyu Wu1Peiyun Yu2Jiawei Xu3Ming Liu4Guang Yang5Zhou Xiang6Fei Xing7Ulrike Ritz8Animal Experiment Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaWest China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaLIMES Institute, Department of Molecular Brain Physiology and Behavior, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, GermanyOrthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, ChinaOrthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, ChinaAnimal Experiment Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaOrthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Orthopaedics and Traumatology, Biomatics Group, University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, 55131 Mainz, GermanyDepartment of Orthopaedics and Traumatology, Biomatics Group, University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, 55131 Mainz, GermanyIn recent years, three-dimensional (3D) bioprinting has been widely utilized as a novel manufacturing technique by more and more researchers to construct various tissue substitutes with complex architectures and geometries. Different biomaterials, including natural and synthetic materials, have been manufactured into bioinks for tissue regeneration using 3D bioprinting. Among the natural biomaterials derived from various natural tissues or organs, the decellularized extracellular matrix (dECM) has a complex internal structure and a variety of bioactive factors that provide mechanistic, biophysical, and biochemical signals for tissue regeneration and remodeling. In recent years, more and more researchers have been developing the dECM as a novel bioink for the construction of tissue substitutes. Compared with other bioinks, the various ECM components in dECM-based bioink can regulate cellular functions, modulate the tissue regeneration process, and adjust tissue remodeling. Therefore, we conducted this review to discuss the current status of and perspectives on dECM-based bioinks for bioprinting in tissue engineering. In addition, the various bioprinting techniques and decellularization methods were also discussed in this study.https://www.mdpi.com/1996-1944/16/8/3197bioprintingbioinkstissue engineeringdecellularizationtissue repairdecellularized extracellular matrix |
| spellingShingle | Man Zhe Xinyu Wu Peiyun Yu Jiawei Xu Ming Liu Guang Yang Zhou Xiang Fei Xing Ulrike Ritz Recent Advances in Decellularized Extracellular Matrix-Based Bioinks for 3D Bioprinting in Tissue Engineering Materials bioprinting bioinks tissue engineering decellularization tissue repair decellularized extracellular matrix |
| title | Recent Advances in Decellularized Extracellular Matrix-Based Bioinks for 3D Bioprinting in Tissue Engineering |
| title_full | Recent Advances in Decellularized Extracellular Matrix-Based Bioinks for 3D Bioprinting in Tissue Engineering |
| title_fullStr | Recent Advances in Decellularized Extracellular Matrix-Based Bioinks for 3D Bioprinting in Tissue Engineering |
| title_full_unstemmed | Recent Advances in Decellularized Extracellular Matrix-Based Bioinks for 3D Bioprinting in Tissue Engineering |
| title_short | Recent Advances in Decellularized Extracellular Matrix-Based Bioinks for 3D Bioprinting in Tissue Engineering |
| title_sort | recent advances in decellularized extracellular matrix based bioinks for 3d bioprinting in tissue engineering |
| topic | bioprinting bioinks tissue engineering decellularization tissue repair decellularized extracellular matrix |
| url | https://www.mdpi.com/1996-1944/16/8/3197 |
| work_keys_str_mv | AT manzhe recentadvancesindecellularizedextracellularmatrixbasedbioinksfor3dbioprintingintissueengineering AT xinyuwu recentadvancesindecellularizedextracellularmatrixbasedbioinksfor3dbioprintingintissueengineering AT peiyunyu recentadvancesindecellularizedextracellularmatrixbasedbioinksfor3dbioprintingintissueengineering AT jiaweixu recentadvancesindecellularizedextracellularmatrixbasedbioinksfor3dbioprintingintissueengineering AT mingliu recentadvancesindecellularizedextracellularmatrixbasedbioinksfor3dbioprintingintissueengineering AT guangyang recentadvancesindecellularizedextracellularmatrixbasedbioinksfor3dbioprintingintissueengineering AT zhouxiang recentadvancesindecellularizedextracellularmatrixbasedbioinksfor3dbioprintingintissueengineering AT feixing recentadvancesindecellularizedextracellularmatrixbasedbioinksfor3dbioprintingintissueengineering AT ulrikeritz recentadvancesindecellularizedextracellularmatrixbasedbioinksfor3dbioprintingintissueengineering |