SARS-CoV-2 infection as a potential risk factor for the development of cancer
The COVID-19 pandemic has a significant impact on public health and the estimated number of excess deaths may be more than three times higher than documented in official statistics. Numerous studies have shown an increased risk of severe COVID-19 and death in patients with cancer. In addition, the r...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1260776/full |
| _version_ | 1797688838547570688 |
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| author | Natalia Ogarek Paulina Oboza Magdalena Olszanecka-Glinianowicz Piotr Kocelak |
| author_facet | Natalia Ogarek Paulina Oboza Magdalena Olszanecka-Glinianowicz Piotr Kocelak |
| author_sort | Natalia Ogarek |
| collection | DOAJ |
| description | The COVID-19 pandemic has a significant impact on public health and the estimated number of excess deaths may be more than three times higher than documented in official statistics. Numerous studies have shown an increased risk of severe COVID-19 and death in patients with cancer. In addition, the role of SARS-CoV-2 as a potential risk factor for the development of cancer has been considered. Therefore, in this review, we summarise the available data on the potential effects of SARS-CoV-2 infection on oncogenesis, including but not limited to effects on host signal transduction pathways, immune surveillance, chronic inflammation, oxidative stress, cell cycle dysregulation, potential viral genome integration, epigenetic alterations and genetic mutations, oncolytic effects and reactivation of dormant cancer cells. We also investigated the potential long-term effects and impact of the antiviral therapy used in COVID-19 on cancer development and its progression. |
| first_indexed | 2024-03-12T01:37:23Z |
| format | Article |
| id | doaj.art-a162d16c009c42609b334adb12436e97 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-03-12T01:37:23Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-a162d16c009c42609b334adb12436e972023-09-11T05:35:49ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2023-09-011010.3389/fmolb.2023.12607761260776SARS-CoV-2 infection as a potential risk factor for the development of cancerNatalia Ogarek0Paulina Oboza1Magdalena Olszanecka-Glinianowicz2Piotr Kocelak3Pathophysiology Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, The Medical University of Silesia, Katowice, PolandStudents’ Scientific Society at the Pathophysiology Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, The Medical University of Silesia, Katowice, PolandHealth Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, The Medical University of Silesia, Katowice, PolandPathophysiology Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, The Medical University of Silesia, Katowice, PolandThe COVID-19 pandemic has a significant impact on public health and the estimated number of excess deaths may be more than three times higher than documented in official statistics. Numerous studies have shown an increased risk of severe COVID-19 and death in patients with cancer. In addition, the role of SARS-CoV-2 as a potential risk factor for the development of cancer has been considered. Therefore, in this review, we summarise the available data on the potential effects of SARS-CoV-2 infection on oncogenesis, including but not limited to effects on host signal transduction pathways, immune surveillance, chronic inflammation, oxidative stress, cell cycle dysregulation, potential viral genome integration, epigenetic alterations and genetic mutations, oncolytic effects and reactivation of dormant cancer cells. We also investigated the potential long-term effects and impact of the antiviral therapy used in COVID-19 on cancer development and its progression.https://www.frontiersin.org/articles/10.3389/fmolb.2023.1260776/fullcancerexcess deathlong CovidoncogenesisSARS-CoV-2 infection |
| spellingShingle | Natalia Ogarek Paulina Oboza Magdalena Olszanecka-Glinianowicz Piotr Kocelak SARS-CoV-2 infection as a potential risk factor for the development of cancer Frontiers in Molecular Biosciences cancer excess death long Covid oncogenesis SARS-CoV-2 infection |
| title | SARS-CoV-2 infection as a potential risk factor for the development of cancer |
| title_full | SARS-CoV-2 infection as a potential risk factor for the development of cancer |
| title_fullStr | SARS-CoV-2 infection as a potential risk factor for the development of cancer |
| title_full_unstemmed | SARS-CoV-2 infection as a potential risk factor for the development of cancer |
| title_short | SARS-CoV-2 infection as a potential risk factor for the development of cancer |
| title_sort | sars cov 2 infection as a potential risk factor for the development of cancer |
| topic | cancer excess death long Covid oncogenesis SARS-CoV-2 infection |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1260776/full |
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