Subcutaneous, Oral, and Intranasal Immunization of BALB/c Mice with <i>Leishmania infantum</i> K39 Antigen Induces Non-Protective Humoral Immune Response

Subcutaneous, Oral, and Intranasal Immunization of BALB/c Mice with <i>Leishmania infantum</i> K39 Antigen Induces Non-Protective Humoral Immune Response

Visceral leishmaniasis is a high-burden disease caused by parasites of the <i>Leishmania</i> genus. The K39 kinesin is a highly antigenic protein of <i>Leishmania infantum</i>, but little is known about the immune response elicited by this antigen. We evaluated the humoral im...

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Bibliographic Details
Main Authors: Bruno Bezerra da Silva, Amauri Barbosa da Silva Junior, Lucelina da Silva Araújo, Eduarda Nattaly Ferreira Nobre Santos, Ana Cláudia Marinho da Silva, Eridan Orlando Pereira Tramontina Florean, Maurício Fraga van Tilburg, Maria Izabel Florindo Guedes
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Tropical Medicine and Infectious Disease
Subjects:
visceral leishmaniasis
K39
immunization
humoral response
recombinant protein
Online Access:https://www.mdpi.com/2414-6366/8/9/444

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