Zn-modified In2O3 nanoparticles: Facile synthesis, characterization, and selective cytotoxicity against human cancer cells
Oxide nanoparticles (NPs) have attracted considerable interest owing to their unique characteristics and possible applications, including gas detection, bioanalytical sensing, catalytic, and biomedical. The present work was designed to explore the effect of varying amounts (2.5 %, 5 %, and 7.5 mol%)...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Journal of King Saud University: Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364723004779 |
| _version_ | 1797405519061712896 |
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| author | ZabnAllah M. Alaizeri Hisham A. Alhadlaq Mohd Javed Akhtar Saad Aldawood |
| author_facet | ZabnAllah M. Alaizeri Hisham A. Alhadlaq Mohd Javed Akhtar Saad Aldawood |
| author_sort | ZabnAllah M. Alaizeri |
| collection | DOAJ |
| description | Oxide nanoparticles (NPs) have attracted considerable interest owing to their unique characteristics and possible applications, including gas detection, bioanalytical sensing, catalytic, and biomedical. The present work was designed to explore the effect of varying amounts (2.5 %, 5 %, and 7.5 mol%) of Zn-doping on the properties and selective anticancer efficacy of In2O3 NPs. The precipitation process was applied to prepare pure In2O3 NPs and Zn-doped In2O3 NPs. XRD, TEM, SEM, EDX, XPS, UV–Vis, and PL techniques have been employed to investigate the physicochemical properties of NPs. The XRD analysis revealed that the crystallite of the In2O3 lattice was slightly changed with the addition of Zn ions. TEM and SEM images displayed that the reduction of size of In2O3 NPs was increased with increasing Zn concentrations. The composition elements and distribution of Zn dopants within In2O3 NPs were further confirmed by EDX and XPS techniques. Based on the UV–Vis study, increasing the Zn amount improved the gap energy of In2O3 NPs by shifting edge absorption peaks to lower wavelengths. Moreover, PL spectra show that the intensity of In2O3 NPs decreased with increasing the Zn amount. The biological results indicate that the Zn-doped In2O3 NPs exhibited a significant increase in cytotoxicity with Zn doping increased against MCF-7 and HCT116cells while they have excellent biocompatibility with normal human cells (HUVECs). These results suggest that these NPs hold promise as a novel therapeutic approach in cancer treatment. This study requires more research into the biological applications of Zn-doped In2O3 NPs. |
| first_indexed | 2024-03-09T03:11:11Z |
| format | Article |
| id | doaj.art-a165ee6c80ce40608eb3e4692b344d64 |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-03-09T03:11:11Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-a165ee6c80ce40608eb3e4692b344d642023-12-04T05:21:23ZengElsevierJournal of King Saud University: Science1018-36472024-01-01361103015Zn-modified In2O3 nanoparticles: Facile synthesis, characterization, and selective cytotoxicity against human cancer cellsZabnAllah M. Alaizeri0Hisham A. Alhadlaq1Mohd Javed Akhtar2Saad Aldawood3Corresponding author.; Department of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaOxide nanoparticles (NPs) have attracted considerable interest owing to their unique characteristics and possible applications, including gas detection, bioanalytical sensing, catalytic, and biomedical. The present work was designed to explore the effect of varying amounts (2.5 %, 5 %, and 7.5 mol%) of Zn-doping on the properties and selective anticancer efficacy of In2O3 NPs. The precipitation process was applied to prepare pure In2O3 NPs and Zn-doped In2O3 NPs. XRD, TEM, SEM, EDX, XPS, UV–Vis, and PL techniques have been employed to investigate the physicochemical properties of NPs. The XRD analysis revealed that the crystallite of the In2O3 lattice was slightly changed with the addition of Zn ions. TEM and SEM images displayed that the reduction of size of In2O3 NPs was increased with increasing Zn concentrations. The composition elements and distribution of Zn dopants within In2O3 NPs were further confirmed by EDX and XPS techniques. Based on the UV–Vis study, increasing the Zn amount improved the gap energy of In2O3 NPs by shifting edge absorption peaks to lower wavelengths. Moreover, PL spectra show that the intensity of In2O3 NPs decreased with increasing the Zn amount. The biological results indicate that the Zn-doped In2O3 NPs exhibited a significant increase in cytotoxicity with Zn doping increased against MCF-7 and HCT116cells while they have excellent biocompatibility with normal human cells (HUVECs). These results suggest that these NPs hold promise as a novel therapeutic approach in cancer treatment. This study requires more research into the biological applications of Zn-doped In2O3 NPs.http://www.sciencedirect.com/science/article/pii/S1018364723004779Precipitation processZn dopingAnticancer activityPhysicochemical propertiesSelective cytotoxicity |
| spellingShingle | ZabnAllah M. Alaizeri Hisham A. Alhadlaq Mohd Javed Akhtar Saad Aldawood Zn-modified In2O3 nanoparticles: Facile synthesis, characterization, and selective cytotoxicity against human cancer cells Journal of King Saud University: Science Precipitation process Zn doping Anticancer activity Physicochemical properties Selective cytotoxicity |
| title | Zn-modified In2O3 nanoparticles: Facile synthesis, characterization, and selective cytotoxicity against human cancer cells |
| title_full | Zn-modified In2O3 nanoparticles: Facile synthesis, characterization, and selective cytotoxicity against human cancer cells |
| title_fullStr | Zn-modified In2O3 nanoparticles: Facile synthesis, characterization, and selective cytotoxicity against human cancer cells |
| title_full_unstemmed | Zn-modified In2O3 nanoparticles: Facile synthesis, characterization, and selective cytotoxicity against human cancer cells |
| title_short | Zn-modified In2O3 nanoparticles: Facile synthesis, characterization, and selective cytotoxicity against human cancer cells |
| title_sort | zn modified in2o3 nanoparticles facile synthesis characterization and selective cytotoxicity against human cancer cells |
| topic | Precipitation process Zn doping Anticancer activity Physicochemical properties Selective cytotoxicity |
| url | http://www.sciencedirect.com/science/article/pii/S1018364723004779 |
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