Autophagy as a Vital Therapy Target for Renal Cell Carcinoma
Autophagy is a process that degrades and recycles superfluous organelles or damaged cellular contents. It has been found to have dual functions in renal cell carcinoma (RCC). Many autophagy-related proteins are regarded as prognostic markers of RCC. Researchers have attempted to explore synthetic an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2020.518225/full |
| _version_ | 1818458561164869632 |
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| author | Ying-hua He Guo Tian |
| author_facet | Ying-hua He Guo Tian |
| author_sort | Ying-hua He |
| collection | DOAJ |
| description | Autophagy is a process that degrades and recycles superfluous organelles or damaged cellular contents. It has been found to have dual functions in renal cell carcinoma (RCC). Many autophagy-related proteins are regarded as prognostic markers of RCC. Researchers have attempted to explore synthetic and phytochemical drugs for RCC therapy that target autophagy. In this review, we highlight the importance of autophagy in RCC and potential treatments related to autophagy. |
| first_indexed | 2024-12-14T23:00:25Z |
| format | Article |
| id | doaj.art-a167125d33b84fdfad73da0bf74a5740 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-14T23:00:25Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-a167125d33b84fdfad73da0bf74a57402022-12-21T22:44:28ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-02-011110.3389/fphar.2020.518225518225Autophagy as a Vital Therapy Target for Renal Cell CarcinomaYing-hua He0Guo Tian1Department of Clinical Pharmacy, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaHepatobiliary and Pancreatic Intervention Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaAutophagy is a process that degrades and recycles superfluous organelles or damaged cellular contents. It has been found to have dual functions in renal cell carcinoma (RCC). Many autophagy-related proteins are regarded as prognostic markers of RCC. Researchers have attempted to explore synthetic and phytochemical drugs for RCC therapy that target autophagy. In this review, we highlight the importance of autophagy in RCC and potential treatments related to autophagy.https://www.frontiersin.org/articles/10.3389/fphar.2020.518225/fullautophagyrccinhibitorinducersPI3K/AKT/mTORAMPK/mTOR |
| spellingShingle | Ying-hua He Guo Tian Autophagy as a Vital Therapy Target for Renal Cell Carcinoma Frontiers in Pharmacology autophagy rcc inhibitor inducers PI3K/AKT/mTOR AMPK/mTOR |
| title | Autophagy as a Vital Therapy Target for Renal Cell Carcinoma |
| title_full | Autophagy as a Vital Therapy Target for Renal Cell Carcinoma |
| title_fullStr | Autophagy as a Vital Therapy Target for Renal Cell Carcinoma |
| title_full_unstemmed | Autophagy as a Vital Therapy Target for Renal Cell Carcinoma |
| title_short | Autophagy as a Vital Therapy Target for Renal Cell Carcinoma |
| title_sort | autophagy as a vital therapy target for renal cell carcinoma |
| topic | autophagy rcc inhibitor inducers PI3K/AKT/mTOR AMPK/mTOR |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2020.518225/full |
| work_keys_str_mv | AT yinghuahe autophagyasavitaltherapytargetforrenalcellcarcinoma AT guotian autophagyasavitaltherapytargetforrenalcellcarcinoma |