Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles

Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles

Abstract Background Messenger RNA (mRNA) has gained remarkable attention as an alternative to DNA-based therapies in biomedical research. A variety of biodegradable nanoparticles (NPs) has been developed including lipid-based and polymer-based systems for mRNA delivery. However, both systems still l...

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Bibliographic Details
Main Authors: Hanzey Yasar, Alexander Biehl, Chiara De Rossi, Marcus Koch, Xabi Murgia, Brigitta Loretz, Claus-Michael Lehr
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Nanobiotechnology
Subjects:
mRNA
Transfection
Gene delivery
Chitosan-PLGA
Cationic lipid
Live cell imaging
Online Access:http://link.springer.com/article/10.1186/s12951-018-0401-y

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